| Project/Area Number |
21591603
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
MONNOZEN Satoru 弘前大学, 大学院・保健学研究科, 助教 (20514136)
TERASHIMA Shingo 弘前大学, 大学院・保健学研究科, 助教 (00583733)
HAZAWA Masakatsu 放射線医学総合研究所, 緊急被ばく医療研究センター, 博士研究員 (40622460)
YOSHINO Hironori 弘前大学, 大学院・保健学研究科, 助教 (10583734)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | アスコルビン酸 / 放射線治療 / 癌 / 放射線 / 細胞死 / 併用療法 / ヌードマウス / 腫瘍移植 / 放射線生物学 / 放射縁抵抗性 |
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| Research Abstract |
This study was conducted to examine the utility of the combined use of ascorbic acid (AsA) and radiation in clinical applications. AsA induced cell death and the number of living cells significantly decreased after combined X-ray irradiation and AsA treatment in comparison with that after X-ray irradiation alone in four all cell lines (HL60, HT1080, SAS, A549). This result suggested that the combined X-ray and AsA treatment was effective against cancer cells and the clinical applications should be examined in the future.
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