Basic study of heavy-ion irradiated to the normal brain tissue-Effects of carbon

• Project/Area Number: 21591607
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Chiba University
• Principal Investigator: UNO Takashi 千葉大学, 大学院・医学研究院・放射線医学, 准教授 (30302540)
• Co-Investigator(Kenkyū-buntansha): INOUE Kouhei 千葉大学, 医学部・附属病院・放射線科, 助教 (40312053) ; 磯部 公一 千葉大学, 医学部附属病院, 講師 (80334184)
• Co-Investigator(Renkei-kenkyūsha): ISOBE Kouichi 千葉大学, 医学部・附属病院・放射線科, 講師 (80334184)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 放射線治療生物学 / 重粒子線 / 脳照射 / 放射線障害 / 母性行動 / マウス / 重粒子

Research Abstract

Radiation therapy is applied to several brain tumors. This experiment was planned to investigate influence on maternal behavior after the irradiation exposure to brain. The present study was designed to determine whether irradiation (carbon particles 290 MeV/nucleon, Mono Peak 15-45Gy, irradiation field 5mm cube) to cerebrum modifies the maternal behavior of mice. The maternal behavior items were recorded : nest-building (nest weights) and retrieving behavior (Scoring : the time when a mouse takes children back to the nest) of female mice. The 15-30Gy irradiation groups, the maternal behavior was no changed in comparison with non-irradiated (Control) female mice after 3 month following irradiation. However, maternal behavior activity of 45Gy irradiation group decreased. Particularly, the 45Gy irradiation group was suppressed for the retrieving behavior in 3 and 6 months after irradiation.

Research Products

• [Journal Article] Phase II study of oral S-1 and concurrent radiotherapy in patients with unresectable locally advanced pancreatic cancer. (2011)
  • Author(s): Sudo K, Yamaguchi T, Ishihara T, Nakamura K, Hara T, Denda T, Tawada K, Imagumbai T, Araki H, Sakai M, Hatano K, Kawakami H, Uno T, Ito H, Yokosuka O.
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 80 Pages: 119-125
  • Peer Reviewed
• [Journal Article] JCOG Radiation Therapy Study Group. A consensus-based guideline defining clinical target volume for primary disease in external beam radiotherapy for intact uterine cervical cancer (2011)
  • Author(s): Toita T, Ohno T, Kaneyasu Y, Kato T, Uno T, Hatano K, Norihisa Y, Kasamatsu T, Kodaira T, Yoshimura R, Ishikura S, Hiraoka M
  • Journal Title: Jpn J Clin Oncol Volume: 41 Pages: 1119-1126
  • Peer Reviewed
• [Journal Article] Phase II study of oral S-1 and concurrent radiotherapy in patients with unresectable locally advanced pancreatic cancer (2011)
  • Author(s): Sudo K, Yamaguchi T, Ishihara T, Nakamura K, Uno T, et al.
  • Journal Title: Int J Radiat Oncol Biol Phys Volume: 80 Pages: 119-125
  • Peer Reviewed
• [Journal Article] JCOG Radiation Therapy Study Group. A consensus-based guideline defining clinical target volume for primary disease in external beam radiotherapy for intact uterine cervical cancer (2011)
  • Author(s): Toita T, Ohno T, Kaneyasu Y, Kato T, Uno T, et.al.
  • Journal Title: hermal.Med. Volume: 41 Pages: 1119-1126
  • Peer Reviewed
• [Journal Article] A cooperative phase II study of concurrent chemoradiotherapy for uterine cervical cancer (2011)
  • Author(s): Toita T., Kato S., Ishikura S., Tsujino K, Kodaira T, Uno, et.al.
  • Journal Title: J Radiat Res Volume: 16 Pages: 379-386
  • Peer Reviewed
• [Journal Article] Effect of an ATM kinase inhibitor on thermo- and/or radio-sensitization in non-proliferating normal human fibroblasts and osteosarcoma cells. (2010)
  • Author(s): Inoue, K., Kawata, T., Saito, M., Liu, C., Uno, T., Isobe, K., Ito, H.
  • Journal Title: Thermal Volume: 26 Pages: 97-107
  • NAID: 130004504384
  • Peer Reviewed
• [Journal Article] Postoperative concurrent daily low-dose cisplatin-based chemoradiation improves the prognosis of patients with pathologic T2b or N1 cervical cancer. (2010)
  • Author(s): Mitsuhashi, A., Uno, T., Usui, H., Tate, S., Hirashiki, K., Kato, K., Kiyohara, H., Kato, S., Ito, H., Shozu, M.
  • Journal Title: Anticancer Res Volume: 30 Pages: 2341-2346
  • Peer Reviewed
• [Journal Article] Fractionated stereotactic radiotherapy as a boost treatment for tumors in the head and neck region (2010)
  • Author(s): Uno, T., Isobe, K., Ueno, N., Fukuda, A., Sudo, S., Shirotori, H., Kitahara, I., Fukushima, T., Ito, H.
  • Journal Title: J. Radiat Volume: 51 Pages: 449-454
  • NAID: 10026564008
  • Peer Reviewed
• [Journal Article] Radiation pneumonitis following twice-daily radiotherapy with concurrent carboplatin and paclitaxel in patients with stage III non-small-cell lung cancer. (2010)
  • Author(s): Kobayashi, H., Uno, T., Isobe, K., Ueno, N., Watanabe, M., Harada, R., Takiguchi, Y., Tatsumi, K., Ito, H.
  • Journal Title: Jpn. J. Clin. Oncol. Volume: 40 Pages: 464-469
  • Peer Reviewed
• [Journal Article] A comparison of chromosome repair kinetics in G(0) and G(1) reveals that enhanced repair fidelity under noncycling conditions accounts for increased potentially lethal damage repair (2010)
  • Author(s): Liu, C., Kawata, T., Shigematsu, N., Cucinotta, F., George, K., Saito, M., Uno, T., Isobe, K., Ito, H.
  • Journal Title: Radiat. Res. Volume: 174 Pages: 566-573
  • Peer Reviewed
• [Journal Article] A consensus-based guideline defining the clinical target volume for pelvic lymph nodes in external beam radiotherapy for uterine cervical cancer. (2010)
  • Author(s): Toita, T., Ohno, T., Kaneyasu, Y., Uno, T., Yoshimura, R., Kodaira, T., Furutani, K., Kasuya, G., Ishikura, S., Kamura, T., Hiraoka, M.
  • Journal Title: Jpn. J. Clin. Oncol. Volume: 40 Pages: 456-463
  • Peer Reviewed
• [Journal Article] Fractionated stereotactic radiotherapy as boost treatment for tumors inthe head and neck region. (2010)
  • Author(s): Takashi UNO, Kouichi ISOBE, et al.
  • Journal Title: J.Radiat.Res. Volume: 51 Pages: 449-454
  • Peer Reviewed
• [Journal Article] Effect of an ATM kinase inhibitor on thermo- and/or radio-sensitization in non-proliferating normal human fibroblasts and osteosarcoma cells. (2010)
  • Author(s): Inoue, K., Kawata, T., Saito, M., Liu, C., Uno, T., Isobe, K., et.Al.
  • Journal Title: Thermal.Med. Volume: 26 Pages: 97-107
  • NAID: 130004504384
  • Peer Reviewed
• [Journal Article] Postoperative concurrent daily low-dose cisplatin-based chemoradiation improves the prognosis of patients with pathologic T2b or N1 cervical cancer. (2010)
  • Author(s): Mitsuhashi, A., Uno, T., et.al.
  • Journal Title: Anticancer Res. Volume: 30 Pages: 2341-2346
  • Peer Reviewed
• [Presentation] Failure pattern in patients with intermediate to high risk cervical cancer treated with postoperative chemoradiat-ion using CT-based target delineation. (2011)
  • Author(s): Takashi Uno, et al.
  • Organizer: The European Society of Gynaecological Oncology.
  • Place of Presentation: ミラノ市、イタリア
  • Year and Date: 2011-09-10
• [Presentation] Failure pattern in patients with intermediate to high risk cervical cancer treated with postoperative chemoradiation using CT-based target delineation (2011)
  • Author(s): Takashi Uno, et al.
  • Organizer: The European Society of Gynaecological Oncology
  • Place of Presentation: ミラノ市、イタリア
  • Year and Date: 2011-09-10