Chemoradiotherapy targeting autophagy mechanism against pancreas cancer.
| Project/Area Number |
21591609
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kobe University |
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Principal Investigator |
OKAMOTO Yoshiaki 神戸大学, 大学院・医学研究科, 非常勤講師 (20362791)
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Ryohei 神戸大学, 医学部附属病院, 特命准教授 (30346267)
SUGIMURA Kazuro 神戸大学, 大学院・医学研究科, 教授 (00136384)
NISHIMURA Hideki 神戸大学, 医学部附属病院, 特命講師 (80444610)
YOSHIDA Kenji 神戸大学, 医学部附属病院, 助教 (80351906)
SUZUKI Yoko 神戸大学, 大学院・医学研究科, 技術補佐員 (70448182)
TSUJIMURA Toshiaki 神戸大学, 大学院・医学研究科, 医学研究員 (30403249)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | オートファジー / 放射線療法 / 膵癌 / 放射線治療 / 膵臓癌 / 併用療法 / 集学的治療 |
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| Research Abstract |
Autophagy is one of the most important intraceller mechanism to radiation and chemotherapy. In this study, we evaluated induction of the autophagy by using human pancreas cancer cells. Autophagy was assessed by electron microscope, western blotting of LC-3. In vivo experiment, gemcitabine and ionizing radiation resulted in synergistic cytotoxicity with induction of autophagy.
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Report
(4 results)
Research Products
(72 results)
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[Journal Article] Multi-institutional analysis of solitary extramedullary plasmacytoma of the head and neck treated with curative radiotherapy2012
Author(s)
Sasaki R, Yasuda K, Abe E, Uchida N, Kawashima M, Uno T, Fujiwara M, Shioyama Y, Kagami Y, Shibamoto Y, Nakata K, Takada Y, Kawabe T, Uehara K, Nibu K, Yamada S
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 82(2)
Pages: 626-34
Related Report
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[Journal Article] Long-term outcome and patterns of failure in primary ocular adnexal mucosa-associated lymphoid tissue lymphoma treated with radiotherapy2012
Author(s)
Hashimoto N, Sasaki R, Nishimura H, Yoshida K, Miyawaki D, Nakayama M, Uehara K, Okamoto Y, Ejima Y, Azumi A, Matsui T, Sugimura K
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Journal Title
Int J Radiat Oncol Biol Phys
Volume: 82(4)
Pages: 1509-14
Related Report
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[Journal Article] The effectiveness of particle radiotherapy for hepatocellular carcinoma associated with inferior vena cava tumor thrombus2011
Author(s)
Komatsu S, Fukumoto T, Demizu Y, Miyawaki D, Terashima K, Niwa Y, Mima M, Fujii O, Sasaki R, Yamada I, Hori Y, Hishikawa Y, Abe M, Ku Y, Murakami M
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Journal Title
J Gastroenterol
Volume: 46(7)
Pages: 913-20
NAID
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[Journal Article] Nuclear factor-kappaB expression as a novel marker of radioresistance in early-stage laryngeal cancer2010
Author(s)
Yoshida K, Sasaki R, Nishimura H, Okamoto Y, Suzuki Y, Kawabe T, Saito M, Otsuki N, Hayashi Y, Soejima T, Nibu K, Sugimura K
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Journal Title
Head Neck
Volume: 32(5)
Pages: 646-55
Related Report
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[Journal Article] Vitamin K2-derived compounds induce growth inhibition in radioresistant cancer cells2010
Author(s)
Amalia H, Sasaki R, Suzuki Y, Demizu Y, Bito T, Nishimura H, Okamoto Y, Yoshida K, Miyawaki D, Kawabe T, Mizushina Y, Sugimura K
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Journal Title
Kobe J Med Sci
Volume: 56(2)
NAID
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[Presentation] Dosimetric Analysis of Patterns of Failure for High-grade Glioma with Multimodality Treatment : Relationship to MIB-1Labeling Index2011
Author(s)
K Uehara, R Sasaki, D Miyawaki, H Nishimura, K Yoshida, M Nakayama, T Soejima, O Fujii, T Sasayama, K Sugimura
Organizer
American Society of Therapeutic Radiation Oncology(ASTRO) 53rd Annual Meeting
Place of Presentation
Miami FL, USA
Related Report
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[Presentation] Long-term Outcome and Patterns of Failure in Primary Ocular Adnexal MALT Lymphoma Treated with Radiotherapy2011
Author(s)
N Hashimoto, R Sasaki, H Nishimura, K Yoshida, D Miyawaki, Y Okamoto, Y Ejima, A Azumi, T Matsui, K Sugimura
Organizer
American Society of Therapeutic Radiation Oncology(ASTRO) 53rd Annual Meeting
Place of Presentation
Miami FL, USA
Related Report
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[Presentation] Microplanar Beams Radiation : Is Brain Really A Serial Organ?2011
Author(s)
N Mukumoto, R Sasaki, H Akasaka, M Nakayama, D Miyawaki, H Nishimura, K Umetani, T Kondoh, K Shinohara, K Sugimura
Organizer
American Society of Therapeutic Radiation Oncology(ASTRO) 53rd Annual Meeting
Place of Presentation
Miami FL, USA
Related Report
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