| Project/Area Number |
21591609
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kobe University |
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Principal Investigator |
OKAMOTO Yoshiaki 神戸大学, 大学院・医学研究科, 非常勤講師 (20362791)
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| Co-Investigator(Kenkyū-buntansha) |
SASAKI Ryohei 神戸大学, 医学部附属病院, 特命准教授 (30346267)
SUGIMURA Kazuro 神戸大学, 大学院・医学研究科, 教授 (00136384)
NISHIMURA Hideki 神戸大学, 医学部附属病院, 特命講師 (80444610)
YOSHIDA Kenji 神戸大学, 医学部附属病院, 助教 (80351906)
SUZUKI Yoko 神戸大学, 大学院・医学研究科, 技術補佐員 (70448182)
TSUJIMURA Toshiaki 神戸大学, 大学院・医学研究科, 医学研究員 (30403249)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | オートファジー / 放射線療法 / 膵癌 / 放射線治療 / 膵臓癌 / 併用療法 / 集学的治療 |
|---|
| Research Abstract |
Autophagy is one of the most important intraceller mechanism to radiation and chemotherapy. In this study, we evaluated induction of the autophagy by using human pancreas cancer cells. Autophagy was assessed by electron microscope, western blotting of LC-3. In vivo experiment, gemcitabine and ionizing radiation resulted in synergistic cytotoxicity with induction of autophagy.
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