Identification of the therapeutic effect of new enzyme-targeting radiosensitization treatment, KORTUC for tumor stem cells

• Project/Area Number: 21591610
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kochi University
• Principal Investigator: OGAWA Yasuhiro 高知大学, 教育研究部・医療学系, 教授 (90152397)
• Co-Investigator(Renkei-kenkyūsha): NISHIOKA Akihito 高知大学, 教育研究部・医療学系, 准教授 (70237668) ; KARIYA Shinji 高知大学, 教育研究部・医療学系, 助教 (20314990)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
• Keywords: 放射線腫瘍学 / 乳癌 / 過酸化水素 / 腫瘍幹細胞 / ヒアルロン酸 / 放射線増感剤 / KORTUC / オキシドール / CD44 / 放射線治療 / 低酸素細胞 / 酸素化 / リソソーム / アポトーシス / 酵素化

Research Abstract

Using PET-CT and MRI, the therapeutic effects of new enzyme-targeting radiosensitization treatment, KORTUC were evaluated following the treatment for breast cancer patients treated by KORTUC without any surgical procedure. CD44-positive breast cancer cells thought to be breast cancer stem cells were detected by an immunohistochemical method using biopsy specimens obtained prior to the treatment. As a results, it was concluded that KORTUC exerted fully therapeutic effect irrespective of the existence of CD44-positive tumor cells.

Research Products

• [Journal Article] Safety and effectiveness of a new enzyme-targeting radiosensitization treatment(KORTUC II) for intratumoral injection for low-LET radioresistant tumors (2011)
  • Author(s): Ogawa Y, Kubota K, Ue H, Tadokoro M, Matsui R, Yamanishi T, Hamada N, Kariya S, Nishioka A, Nakajima H, Tarutani M, Sano S
  • Journal Title: Int J Oncol Volume: 39 Pages: 553-560
  • Peer Reviewed
• [Journal Article] Evaluation of changes in tunor shadows and microcalcifications on mammography following KORTUC II, a new radiosensitization treatment without any surgical procedure for elderly patients with stage I and II breast cancer (2011)
  • Author(s): Tsuzuki A, Ogawa Y, Kubota K, Tokuhiro S, Akima R, Yaogawa S, Itoh zk, Yamada Y, Sasaki T, Onogawa M, Yamanishi T, Kariya S, Nogami M, Nishioka A, Miyamura M
  • Journal Title: Cancers Volume: 3 Pages: 3496-3505
  • Peer Reviewed
• [Journal Article] Safety and effectiveness of a new enzyme-targeting radiosensitization (2011)
  • Author(s): Ogawa Y, et al
  • Journal Title: Int J Oncol Volume: 39 Pages: 553-560
  • DOI: 10.3892/ijo.2011.1069
  • Peer Reviewed
• [Journal Article] Evaluation of changes in tumor shadows and microcalcification on (2011)
  • Author(s): Tsuzuki A, Ogawa Y, et al
  • Journal Title: Cancers Volume: 3 Issue: 3 Pages: 3496-3505
  • DOI: 10.3390/cancers3033496
  • Peer Reviewed
• [Journal Article] Non-surgical care for locally advanced breast cancer : Radiologically assessed therapeutic outcome of a new enzyme-targeting radiosensitization treatment, Kochi Oxydol-radiation therapy for unresectable carcinomas, type II(KORTUC II) with systemic chemotherapy (2010)
  • Author(s): Miyatake K, Kubota K, Ogawa Y, Hamada N, Murata Y, Nishioka A
  • Journal Title: Oncol Rep Volume: 34 Pages: 1161-1168
  • Peer Reviewed
• [Journal Article] Non-surgical therapy and radiologic assessment of stage I breast cancer treatment with novel enzyme-targeting radiosensitization : Kochi Oxydol-radiation therapy for unresectable carcinomas, type II(KORTUC II) (2010)
  • Author(s): Hitomi J, Kubota K, Ogawa Y, Hamada N, Murata Y, Nishioka A
  • Journal Title: Exp Ther Med Volume: 1 Pages: 769-775
  • Peer Reviewed
• [Journal Article] Development of a new enzyme-targeting radiosensitizer(KORTUC) containing hydrogen peroxide for intratumoral injection for patients with low linear energy transfer(LET) radioresistant neoplasms (2010)
  • Author(s): Tokuhiro S, Ogawa Y, Tsuzuki A, Akima R, Ue H, Kariya S, Nishioka A
  • Journal Title: Oncol Lett Volume: 1 Pages: 1025-1028
  • Peer Reviewed
• [Journal Article] Non-surgical therapy and radiologic assessment of stage I breast cancer treatment with novel enzyme-targeting radiosensitization, KORTUC II (2010)
  • Author(s): Hitomi J, Kubota K, Ogawa Y, et al
  • Journal Title: Exp Ther Med Volume: 1 Pages: 769-775
  • Peer Reviewed
• [Journal Article] Non-surgical care for locally advanced breast cancer : Radiologically assessed therapeutic outcome of a new enzyme-targeting radiosensitization… (2010)
  • Author(s): Miyatake K, Kubota K, Ogawa Y, et al
  • Journal Title: Oncol Rep Volume: 24 Pages: 1161-1168
  • Peer Reviewed
• [Journal Article] Development of a new enzyme-targeting radiosensitizer (KORTUC) containing hydrogen peroxide for intratumoral injection for patients…… (2010)
  • Author(s): Tokuhiro S, Ogawa Y, et al
  • Journal Title: Oncol Letters Volume: 1 Pages: 1025-1028
  • Peer Reviewed
• [Journal Article] Combination treatment of hydrogen peroxide and x-rays induces apoptos is in human prostate cancer PC-3 cells (2009)
  • Author(s): 刈谷真爾
  • Journal Title: Int J Radiation Oncology Biol.Phys. 75 Pages: 449-454
  • Peer Reviewed
• [Journal Article] 新開発の放射線増感剤(過酸化水素含有ヒアルロン酸ナトリウム)による著明な臨床効果 (2009)
  • Author(s): 小川恭弘
  • Journal Title: 癌の臨床 55 Pages: 255-272
  • Peer Reviewed
• [Journal Article] 新しい酵素標的・増感放射線療法KORTUCの臨床応用の現状と将来展望 (2009)
  • Author(s): 小川恭弘
  • Journal Title: 臨祥放射線 54 Pages: 1251-1263
  • Peer Reviewed
• [Presentation] Safety and efficacy of intraoperative radiotherapy with image-guided enzyme targeting radiosensitization(KORTUC-IORT) for advanced pancreatic cancer (2011)
  • Author(s): Nishioka A, Ogawa Y, Suzuki Y, Tadokoro M, Kariya S, Hamada N, Kubota K
  • Organizer: 53^<rd> Annual Meeting of the American Society for Radiation Oncology
  • Place of Presentation: Miami Beach, USA
  • Year and Date: 2011-10-04
• [Presentation] KORTUC II. A new image-guided, enzyme-targeted, and breast cancer stem cell targeted radiosensitization treatment for patients with stage I and II breast cancers (2011)
  • Author(s): Ogawa Y, Kubota K, Tadokoro M, Yamanishi T, Aoyama N, Suzuki Y, Iwasa H, Kariya S, Nogami M, Nishioka A
  • Organizer: 53^<rd> Annual Meeting of the American Society for Radiation Oncology
  • Place of Presentation: Miami Beach, USA
  • Year and Date: 2011-10-03
• [Presentation] Safety and efficacy of new enzyme targeting intraoperative radiotherapy for locally advanced pancreatic cancer (2010)
  • Author(s): Nishioka A, Ogawa Y, Kariya S, Miyatake K, Tadokoro M, Ue H, Matsui R, Hamada N, Kubota K
  • Organizer: 52nd Annual Meeting of the American Society for Radiation Oncology
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-03
• [Presentation] Evaluation of changes of tumor shadows and micro-calcifications on mammography following a new radiosensitization treatment(KORTUC II) for aged patients with breast cancer of stages I and II (2010)
  • Author(s): Tsuzuki A, Ogawa Y, Kubota K, Nishioka A, Akima R, Tokuhiro S, Yaogawa S, Yamada Y, Sasaki T, Geshi H
  • Organizer: 52nd Annual Meeting of the American Society for Radiation Oncology
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-11-02
• [Presentation] Phase I study of intra-tumoral injection of a newly developed enzyme-targeting radiosensitizer(KORTUC)containing hydrogen peroxide… (2009)
  • Author(s): 小川恭弘
  • Organizer: Joint ECCO 15-34^<th> ESMO Multidisciplinary Congress
  • Place of Presentation: Berlin, Germany ベルリン国際会議場
  • Year and Date: 2009-09-22
• [Book] 癌の臨床特集酵素標的・増感放射線療法KORTUCの基礎と臨床 (2011)
  • Author(s): 小川恭弘, 他
  • Publisher: 篠原出版新社