Inhibition and amelioration of radiation induced lung fibroproliferation by TGF-βinhibition

• Project/Area Number: 21591611
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Kochi University
• Principal Investigator: NISHIOKA Akihito 高知大学, 教育研究部・医療学系, 准教授 (70237668)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 放射線治療 / 肺傷害 / 線維化関連分子 / TGF-β / YGF-β

Research Abstract

We investigated whether the inhibition of TGF-βactions could inhibit or ameliorate fibroproliferative change in rat irradiated lung. We used the anti-body for TGF-βthat can adsorb TGF-βitself and that may inhibit the functions of the TGF-β. Our data indicate that TGF-βdoes play a critical role in radiation-induced pulmonary damage. Our results suggest that TGF-βinhibition by the antibody could be effective for the inhibition or amelioration of radiation-induced fibrosis in the lung. Possible side-effects of TGF-βinhibition over the long-term such as carcinogenesis should be carefully examined.