Overcoming the radioresistance in hypoxic cancer cells by using hydrogen peroxide
| Project/Area Number |
21591612
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kochi University |
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Principal Investigator |
KARIYA Shinji 高知大学, 教育研究部・医療学系, 助教 (20314990)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 癌 / 放射線 / 低酸素細胞 |
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| Research Abstract |
Cancer cells in hypoxic conditions are known familiarly as X-ray resistant. When cancer cells were exposed to hydrogen peroxide just before the X-irradiation, the cells in hypoxic condition occurred death more than cancer cells in normoxic conditions. When hydrogen peroxide was administered into cell medium, oxygen generated. In our study, however, the oxygen pressure increased in the medium was a mere 3. 6 mmHg, which was not enough for hypoxic conditions to become normoxic conditions. It is considered that subcellular organella such as lysosome are concerned with this cell death.
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Report
(4 results)
Research Products
(8 results)
