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Significance of hypoxia-related genes to predict the tumor response to radiotherapy in patients with oropharyngeal cancer

Research Project

Project/Area Number 21591615
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionOsaka University (2011)
University of the Ryukyus (2009-2010)

Principal Investigator

OGAWA Kazuhiko  大阪大学, 医学系研究科, 教授 (40253984)

Co-Investigator(Kenkyū-buntansha) YOSHIMI Naoki  琉球大学, 大学院・医学研究科, 教授 (30166996)
SUZUKI Mikio  琉球大学, 大学院・医学研究科, 教授 (00226557)
IIDA Gyou  琉球大学, 医学部附属病院, 助教 (60404571)
玉城 稚奈  国立大学法人琉球大学, 医学部附属病院, 助教 (00381236)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords放射線治療生物学 / 中咽頭癌 / 放射線治療 / 低酸素 / 遺伝子 / 治療効果 / 放射線治療効果
Research Abstract

This study is aimed to elucidate the significance of hypoxia-related genes to predict the tumor response to radiotherapy in patients with oropharyngeal cancer. We are currently conducting the analyses using real-time PCR and immunohistochemical study, and investigating whether hypoxia-related genes can predict the tumor response to radiotherapy in patients with oropharyngeal cancer.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (6 results)

All 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (2 results)

  • [Journal Article] Clinical significance of HIF-1alpha expression in patients with esophageal cancer treated with concurrent chemoradiotherapy2011

    • Author(s)
      Ogawa K, Chiba I, Morioka T, Shimoji H, Tamaki W, Takamatsu R, Nishimaki T, Yoshimi N, Murayama S.
    • Journal Title

      Anticancer Res

      Volume: 31(6) Pages: 2351-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of GLUT-1 expression in patients with esophageal cancer treated with concurrent chemoradiotherapy2011

    • Author(s)
      Ogawa K, Chiba I, Morioka T, Shimoji H, Iraha S, Takamatsu R, Nishimaki T, Yoshimi N, Murayama S.
    • Journal Title

      Anticancer Res

      Volume: 2(1) Pages: 21-28

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of HIF-1 alpha epression in patients with esophageal cancer treated with concurrent chemoradiotherapy2011

    • Author(s)
      Ogawa K, et al
    • Journal Title

      Anticancer Reserch

      Volume: 31 Pages: 2351-2359

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of GLUT-1 expression in patients with esophageal cancer treated with concurrent chemoradiotherapy2011

    • Author(s)
      Chiba I, Ogawa K, et al
    • Journal Title

      Oncol Lett

      Volume: 2 Issue: 1 Pages: 21-28

    • DOI

      10.3892/ol.2010.199

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 食道癌に対する化学放射線療法同時併用におけるGLUT-1発現の臨床的意義2011

    • Author(s)
      千葉至、小川和彦, 他
    • Organizer
      第70回日本医学放射線学会学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2011-04-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 食道癌に対する化学放射線療法同時併用におけるGLUT-1発現の臨床的意義2011

    • Author(s)
      千葉至、小川和彦、森岡孝満, 下地英明, 砂川奈穂, 伊良波史朗, 西巻正, 吉見直己, 村山貞之
    • Organizer
      第70回日本医学放射線学会総会
    • Place of Presentation
      WEB開催
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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