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Clinico-pathological research for predictive factors of the treatment effects in radiation therapy combined with or without chemotherapy for lung cancer

Research Project

Project/Area Number 21591617
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionKitasato University

Principal Investigator

HAYAKAWA Kazushige  北里大学, 医学部, 教授 (70114189)

Co-Investigator(Kenkyū-buntansha) JIANG Shi-xu  北里大学, 医学部, 講師 (70276153)
MITSUFUJI Hisashi  北里大学, 医学部, 講師 (40260856)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords肺癌 / 放射線療法 / 定位放射線治療 / 分子標的薬 / EGFR / 化学放射線療法 / シスプラチン / ビノレルビン / Gefitinib / EGFR遺伝子 / EGFR-TKI / 放射線治療
Research Abstract

In the patients with peripheral stage I non-small cell lung cancer treated with stereotactic body radiotherapy, the 5-year overall survival rate, cause-specific survival rate and local progression-free rate were 63%, 74% and 72%, respectively. But the patients with squamous cell carcinoma of the lung had a worse prognosis. The immunohistochemical study for EGFR mutation showed that the heterogeneity of gene mutation commonly developed in the various types of lung cancer. The 6B6 antibody staining was specific for EGFR mutation and considered to be useful for screening patients effective to EGFR TKI.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (37 results)

All 2012 2011 2010 2009

All Journal Article (20 results) (of which Peer Reviewed: 8 results) Presentation (12 results) Book (5 results)

  • [Journal Article] Phase I Results of Vinorelbine With Concurrent Radiotherapy in Elderly Patients With Unresectable, Locally Advanced Non-Small-Cell Lung Cancer : West Japan Thoracic Oncology Group(WJTOG3005-DI)2012

    • Author(s)
      Harada H, Seto T, Igawa S, Tsuya A, Wada M, Kaira K, Naito T, Hayakawa K, Nishimura T, Masuda N, Yamamoto N
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 82(5) Pages: 1777-82

    • Related Report
      2011 Final Research Report
  • [Journal Article] Radiotherapy quality assurance review for a multi-center randomized trial of locally advanced esophageal cancer : the Japan Clinical Oncology Group(JCOG) trial 03032012

    • Author(s)
      Sanuki N, Ishikura S, Shinoda M, Ito Y, Hayakawa K, Ando N
    • Journal Title

      Int J Clin Oncol

      Volume: 17(2) Pages: 105-11

    • NAID

      10030626385

    • Related Report
      2011 Final Research Report
  • [Journal Article] Functional organ preservation for laryngeal cancer : past, present and future2012

    • Author(s)
      Nakayama M, Laccourreye O, Holsinger FC, Okamoto M, Hayakawa K
    • Journal Title

      Jpn J Clin Oncol

      Volume: 42(3) Pages: 155-60

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] 肺癌治療における新しい放射線療法2012

    • Author(s)
      早川和重
    • Journal Title

      成人病と生活習慣病

      Volume: 42(1) Pages: 81-86

    • Related Report
      2011 Final Research Report
  • [Journal Article] A phase II trial of neoadjuvant preoperative chemoradiotherapy with S-1 plus irinotecan and radiation in patients with locally advanced rectal cancer : clinical feasibility and response rate2011

    • Author(s)
      Sato T, Ozawa H, Hatate K, Onosato W, Naito M, Nakamura T, Ihara A, Koizumi W, Hayakawa K, Okayasu I, Yamashita K, Watanabe M
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 79(3) Pages: 677-83

    • Related Report
      2011 Final Research Report
  • [Journal Article] Phase I clinical study of NMK36 : a new PET tracer with the synthetic amino acid analogue anti-[(18) F] FACBC2011

    • Author(s)
      Asano Y, Inoue Y, Ikeda Y, Kikuchi K, Hara T, Taguchi C, Tokushige T, Maruo H, Takeda T, Nakamura T, Fujita T, Kumagai Y, Hayakawa K
    • Journal Title

      Ann Nucl Med

      Volume: 25(6) Pages: 414-8

    • NAID

      10029284616

    • Related Report
      2011 Final Research Report
  • [Journal Article] HADHA is a potential predictor of response to platinum-based chemotherapy for lung cancer2011

    • Author(s)
      Kageyama T, Nagashio R, Ryuge S, Matsumoto T, Iyoda A, Satoh Y, Masuda N, Jiang SX, Saegusa M, Sato Y
    • Journal Title

      Asian Pacific Journal of Cancer Prevention

      Volume: 12 Pages: 3457-63

    • Related Report
      2011 Final Research Report
  • [Journal Article] 肺がん(非小細胞肺がん)2011

    • Author(s)
      早川和重
    • Journal Title

      がん治療レクチャー

      Volume: 2(1) Pages: 103-107

    • Related Report
      2011 Final Research Report
  • [Journal Article] 肺癌診療ガイドライン改訂の概要2011

    • Author(s)
      早川和重, 坪井正博
    • Journal Title

      日本胸部臨床

      Volume: 70(2) Pages: 109-117

    • Related Report
      2011 Final Research Report
  • [Journal Article] The radiotnerapy with methotrexate, vinblastine, doxorubicin, and cisplatin treatment is an effective therapeutic option in patients with advanced or metastatic bladder cancer2011

    • Author(s)
      Ikeda M, Hayakawa K, et al
    • Journal Title

      J Radiat Res

      Volume: 52(5) Pages: 674-9

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase I clinical study of NMK36 : a new PET tracer with the synthetic amino acid analogue anti-[(18)F] FACBC2011

    • Author(s)
      Asano Y, Inoue Y, Ikeda Y, Kikuchi K, Hara T, Taguchi C, Tokushige T, Maruo H, Takeda T, Nakamura T, Fujita T, Kumagai Y, Hayakawa K
    • Journal Title

      Ann Nucl Med

      Volume: 25(6) Issue: 6 Pages: 414-418

    • DOI

      10.1007/s12149-011-0477-z

    • NAID

      10029284616

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A phase II trial of neoadjuvant preoperative chemoradiotherapy with S-1 plus irinotecan and radiation in patients with locally advanced rectal cancer : clinical feasibility and response rate.2011

    • Author(s)
      Sato T, Koizumi W, Hayakawa K, Okayasu I, Watanabe M, et al.
    • Journal Title

      Int J Radiat Oncol Biol Phys.

      Volume: 79(3) Pages: 677-83

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] がん治療ガイドラインの検証「肺癌」-EBMの手法による肺癌診療ガイドライン2005年版-2010

    • Author(s)
      早川和重, 坪井正博
    • Journal Title

      と化学療法

      Volume: 37(4) Pages: 609-612

    • Related Report
      2011 Final Research Report
  • [Journal Article] 新しい放射線治療2010

    • Author(s)
      早川和重
    • Journal Title

      成人病と生活習慣病

      Volume: 40(5) Pages: 484-489

    • Related Report
      2011 Final Research Report
  • [Journal Article] 少数転移・少数再発(oligometastases, oligo-recurrence)に対する放射線治療2010

    • Author(s)
      新部譲, 小谷承子, 早田格, 早川和重
    • Journal Title

      日獨医報

      Volume: 55(3・4) Pages: 266-270

    • Related Report
      2011 Final Research Report
  • [Journal Article] Phase I/II Trial of Concurrent Use of S-1 and Radiation Therapy for T2 Glottic Cancer.2010

    • Author(s)
      Nakayama M, Hayakawa K, Okamoto M, Niibe Y, Ishiyama H, Kotani S.
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 40(10) Pages: 921-6

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Initial analysis of relationship between plasma platinum concentration and hematological adverse reaction associated with weekly chemotherapy using nedaplatin in combination with radiotherapy for cervical carcinoma.2010

    • Author(s)
      Hamada Y, Naitoh H, Niibe Y, Unno N, Hayakawa K, Yago K, et al.
    • Journal Title

      Eur J Gynaecol Oncol.

      Volume: 31(5) Pages: 517-21

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful rechallenge with erlotinib in a patient with EGFR-mutant lung adenocarcinoma who developed gefitinib-related interstitial lung disease.2010

    • Author(s)
      Fukui T, Jiang SX, et al.
    • Journal Title

      Cancer Chemother Pharmacol 65

      Pages: 803-806

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single infusion of Zoledronic acid to prevent androgen deprivation therapy-induced bone loss in men with hormone-naive prostate carcinoma2009

    • Author(s)
      Satonh T, Kimura M, Ishiyaman H, Hayakawa K, Baba S, et al.
    • Journal Title

      Cancer 115(15)

      Pages: 3468-74

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genitourinary toxicity after high-dose-rate(HDR)brachytherapy combined with Hypofractionated External beam radiotherapy for localized prostate cancer : an analysis to determine the correlation between dose-volume histogram parameters in HDR brachytherapy and severity of toxicity.2009

    • Author(s)
      Ishiyama H, Kitano M, Satoh T, Baba S, Hayakawa K, et al.
    • Journal Title

      Int J Radiat Oncol Biol Phys 75(1)

      Pages: 23-28

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 非小細胞肺癌I期症例に対する動体追跡を用いた定位放射線照射の治療成績2012

    • Author(s)
      早田格, 早川和重, 新部譲, 石山博條, 小谷承子, 関口茜衣, 井川聡, 三藤久, 片桐真人, 益田典幸
    • Organizer
      第24回日本高精度放射線外部照射研究会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2012-02-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 非小細胞肺癌に対するシスプラチン/ビノレルビン同時併用化学放射線療法の検討2011

    • Author(s)
      早田格, 早川和重, 新部譲, 石山博條, 小谷承子, 関口茜衣, 井川聡, 三藤久, 片桐真人, 益田典幸
    • Organizer
      日本放射線腫瘍学会第24回学術大会
    • Place of Presentation
      神戸
    • Year and Date
      2011-11-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺がん放射線療法の進歩と課題2011

    • Author(s)
      早川和重
    • Organizer
      第49回日本癌治療学会学術集会シンポジウム
    • Place of Presentation
      名古屋国際会議場,名古屋
    • Year and Date
      2011-10-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺がん放射線療法の進歩と課題2011

    • Author(s)
      早川和重
    • Organizer
      第49回日本癌治療学会学術集会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2011-10-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 非小細胞肺癌に対する定位放射線治療2011

    • Author(s)
      早川和重
    • Organizer
      第47回日本医学放射線学会秋季臨床大会シンポジウム
    • Place of Presentation
      海峡メッセ下関・下関市生涯学習プラザ
    • Year and Date
      2011-10-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 非小細胞肺癌に対する定位放射線治療2011

    • Author(s)
      早川和重
    • Organizer
      第47回日本医学放射線学会秋季臨床大会
    • Place of Presentation
      海峡メッセ下関(下関市)
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肺がんに対する化学放射線療法の新展開2011

    • Author(s)
      早川和重
    • Organizer
      日本臨床腫瘍学会/日本放射線腫瘍学会合同シンポジウム第9回日本臨床腫瘍学会学術集会
    • Place of Presentation
      横浜(パシフィコ横浜)
    • Year and Date
      2011-07-22
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺がんに対する化学放射線療法の新展開2011

    • Author(s)
      早川和重
    • Organizer
      日本臨床腫瘍学会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-07-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 肺癌放射線治療の進歩と課題2010

    • Author(s)
      早川和重
    • Organizer
      第92回日本肺癌学会関西支部会
    • Place of Presentation
      薬業年金会館,大阪
    • Year and Date
      2010-07-10
    • Related Report
      2011 Final Research Report
  • [Presentation] 肺癌放射線治療の進歩と課題2010

    • Author(s)
      早川和重
    • Organizer
      第92回日本肺癌学会関西支部会
    • Place of Presentation
      薬業年金会館(大阪)
    • Year and Date
      2010-07-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 肺癌放射線治療の現状と課題2010

    • Author(s)
      早川和重
    • Organizer
      広島肺がん研究会学術講演会
    • Place of Presentation
      広島大学医学部,広仁会館大会議室(広島)
    • Year and Date
      2010-02-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Concurrent chemoradiotherapy using Cisplatin and Vinorelbine for Locally Advanced NSCLC in the Era of 3D Radiotherapy Planning : A Retrospective Analysis of Clinical Practice Data.2009

    • Author(s)
      Hayakawa K, Masuda N, Mitsufuji H, et al.
    • Organizer
      13th World Conference on Lung Cancer,
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2009 Annual Research Report
  • [Book] 放射線療法、新しい診断と治療のABC 34「肺癌」(最新医学別冊)2012

    • Author(s)
      早川和重, 阿部庄作
    • Publisher
      最新医学社
    • Related Report
      2011 Final Research Report
  • [Book] 新しい診断と治療のABC34「肺癌」(阿部庄作編)2012

    • Author(s)
      早川和重(分担)
    • Publisher
      最新医学社,大阪
    • Related Report
      2011 Annual Research Report
  • [Book] 2011-2012 EBM呼吸器疾患の治療2011

    • Author(s)
      早川和重, 永井厚志, 大田健, 大田健, 江口研二, 橋本修
    • Publisher
      中外医学社
    • Related Report
      2011 Final Research Report
  • [Book] がん・放射線療法20102010

    • Author(s)
      早川和重(分担)
    • Total Pages
      1247
    • Publisher
      篠原出版新社
    • Related Report
      2010 Annual Research Report
  • [Book] 日本臨床腫瘍学会編:新臨床腫瘍学(改訂第2版),放射線腫瘍学,pp.236-2452009

    • Author(s)
      早川和重, 他
    • Total Pages
      922
    • Publisher
      南江堂,東京
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2017-10-13  

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