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A prophylaxis and a treatment for radiation induced mucosal damage-Efficacy of zinc to radiation proctitis using an animal experimental model-

Research Project

Project/Area Number 21591622
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionHyogo Medical University

Principal Investigator

KAMIKONYA Norihiko  兵庫医科大学, 医学部, 教授 (00185985)

Co-Investigator(Kenkyū-buntansha) FUJIWARA Masayuki  兵庫医科大学, 医学部, 助教 (90388827)
TAKADA Yasuhiro  兵庫医科大学, 医学部, 助教 (20461048)
HIROTA Shozo  兵庫医科大学, 医学部, 教授 (20181216)
MAEDA Hiroaki  兵庫医科大学, 医学部, 助教 (00388828)
KOBAYASHI Kaoru  兵庫医科大学, 医学部, 助教 (70388817)
YAMAMOTO Satoshi  兵庫医科大学, 医学部, 助教 (50411989)
Co-Investigator(Renkei-kenkyūsha) DOI Hiroshi  兵庫医科大学, 医学部, 助教 (50529047)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords放射線治療学 / 放射線障害 / 直腸粘膜障害 / 亜鉛 / 放射線直腸炎 / 前立腺癌 / 放射線治療 / 前立線癌
Research Abstract

Fifty-four female Wistar rats were used. All rats were irradiated with a single fraction of 25 Gy without any invasive procedures under pentobarbital anesthesia. Polaprezinc was prepared as ointment. Ointment was administrated rectally without any anesthesia each day after irradiation. All animals were sacrificed on the tenth day following irradiation. Colonoscopy was performed to evaluate the macroscopic findings immediately after sacrifice. The rectum was excised for a pathological evaluation following colonoscopy. The pathological evaluation assessed the morphological mucosal damage, the degree of inflammation, and the depth of inflammation. The results were graded from 0 to 4, and compared according to milder or more severe status as applicable. The PZ(+) group tended to show milder mucosal damage than the other groups in all criteria. In addition, significant differences were observed between the PZ(+) group and the Control group in the endoscopic findings, the degree of inflammation and the depth of inflammation. This model was confirmed to be a useful experimental rat model for radiation proctitis. The present study demonstrated the efficacy of Polaprezinc against acute radiation-induced rectaldisorders using the rat model.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (33 results)

All 2011 2010 2009

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (24 results)

  • [Journal Article] 放射線治療に伴う粘膜障害は軽減できるか?亜鉛製剤の有用性に迫る2011

    • Author(s)
      上紺屋憲彦、土井啓至、冨士原将之
    • Journal Title

      口腔・咽頭科

      Volume: 24巻 Pages: 29-34

    • NAID

      10028176408

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of polaprezinc for acute radiation proctitis in a rat model2011

    • Author(s)
      Doi H、Kamikonya N、Takada Y、et al
    • Journal Title

      Int J Radiat Oncol Biol Phys

      Volume: 80巻 Issue: 3 Pages: 877-84

    • DOI

      10.1016/j.ijrobp.2011.01.009

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 放射線治療に伴う粘膜障害は軽減できるか?:亜鉛製剤の有用性に迫る2011

    • Author(s)
      上紺屋憲彦, 土井啓至, 冨士原将之
    • Journal Title

      口咽科

      Volume: 24 Pages: 29-34

    • NAID

      10028176408

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monaco-VMATにおけるQA/QCの実際:スパイラルファントムを用いたVMAT線量検証システム2011

    • Author(s)
      上紺屋憲彦, 田ノ岡征雄
    • Journal Title

      Rad fan

      Volume: 9 Pages: 31-32

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ポラプレジンク坐剤の品質試験と放射性直腸炎に対する臨床評価2010

    • Author(s)
      志方敏幸、中村豪志、日笠真一、濱口常男、土井啓至、上紺屋憲彦, 他
    • Journal Title

      医療薬学

      Volume: 36 Pages: 549-56

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 放射線直腸炎に対する亜鉛製剤直腸内投与の初期経験2010

    • Author(s)
      土井啓至、上紺屋憲彦、高田康弘、冨士原将之
    • Journal Title

      臨床放射線

      Volume: 55巻 Pages: 443-449

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 放射線性直腸炎に対する亜鉛製剤直腸内投与の初期経験2010

    • Author(s)
      土井啓至、上紺屋憲彦、高田康弘、冨士原将之
    • Journal Title

      臨床放射線

      Volume: 55 Pages: 443-449

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ラット放射線性直腸障害モデルを用いた亜鉛製剤の有効性の評価2009

    • Author(s)
      土井啓至、上紺屋憲彦、高田康弘, 他
    • Journal Title

      日放腫会誌

      Volume: 21巻 Pages: 149-154

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ラット放射線性直腸粘膜障害モデルを用いた亜鉛製剤の有効性の評価2009

    • Author(s)
      土井啓至
    • Journal Title

      日本放射線腫瘍学会誌 21

      Pages: 149-154

    • NAID

      10027260392

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 低用量アスピリンは放射線粘膜障害を増悪するか?-動物実験モデルでの検討-2011

    • Author(s)
      土井啓至, 上紺屋憲彦, 高田康弘, 冨士原将之, 井上裕之, 田ノ岡征雄, 三浦英治, 志方敏幸, 木村健, 辻村亨, 廣田省三
    • Organizer
      第298回日本医学放射線学会関西地方会(第369回レントゲンアーベント)
    • Place of Presentation
      大阪
    • Year and Date
      2011-06-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Late rectal injury and microangiopathy after irradiation : A time sequential study in rats2011

    • Author(s)
      Doi H, Kamikonya N, Takada Y, Fujiwara M, Miura H, Inoue H, Tanooka M, Shikata T, Tsujimura T, Hirota S.
    • Organizer
      ASTRO
    • Place of Presentation
      Miami
    • Related Report
      2011 Final Research Report
  • [Presentation] Radiation-induced microangiograthy in the rectum using an animal experimental model2011

    • Author(s)
      Doi H, Kamikonya N, Takada Y, Fujiwara M, Miura H, Inoue H, Tanooka M, Shikata T, Tsujimura T
    • Organizer
      European Multidisciplinary Cancer Congress
    • Place of Presentation
      Stockholm
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Late rectal toxicity following irradiation in rats2011

    • Author(s)
      Doi H、Kamikonya N、Takada Y、Fujiwara M、Tsuboi K、Miura H、Inoue H、Tanooka M、Nakamura T、Shikata T、Tsujimura T、Hirota S
    • Organizer
      European Society for Therapeutic Radiology and Oncology
    • Place of Presentation
      London
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Radiation-induced rectal toxicity in rats on low-dose aspirin therapy2011

    • Author(s)
      Doi H, Kamikonya N, Takada Y, Fujiwara M, Miura H, Inoue H, Tanooka M, Nakamura, Tsujimura T, Hirota S
    • Organizer
      European Multidisciplinary Cancer Congress
    • Place of Presentation
      Stockholm
    • Related Report
      2011 Annual Research Report
  • [Presentation] Late rectal injury and microangiopathy after irradiation : A time sequential study in rats2011

    • Author(s)
      Doi H, Kamikonya N, Takada Y, Fujiwara M, Miura H, Inoue H, Tanooka M, Shikata T, Tsujimura T, Hirota S
    • Organizer
      ASTRO 2011
    • Place of Presentation
      Miami
    • Related Report
      2011 Annual Research Report
  • [Presentation] The impact of low-dose aspirin on radiation proctitis in rats2011

    • Author(s)
      Doi H, Kamikonya N, Takada Y, Fujiwara M, Miura H, Inoue H, Tanooka M, Nakamura T, Tsujimura T, Hirota S
    • Organizer
      ASTRO 2011
    • Place of Presentation
      Miami
    • Related Report
      2011 Annual Research Report
  • [Presentation] 直腸への選択的放射線照射ラットの長期自然経過とその病理組織学的検討2011

    • Author(s)
      土井啓至, 井上裕之, 田ノ岡征雄, 三浦英治, 上紺屋憲彦, 高田康弘, 冨士原将之, 中村豪志, 辻村亨, 廣田省三
    • Organizer
      第70回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] 低用量アスピリンの放射線直腸炎への影響-動物実験モデルにおける検討-2011

    • Author(s)
      土井啓至, 上紺屋憲彦, 高田康弘, 冨士原将之, 三浦英治, 井上裕之, 田ノ岡征雄, 中村豪志, 辻村亨, 廣田省三
    • Organizer
      日本放射線腫瘍学会第24回学術大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report
  • [Presentation] 当院における前立腺癌放射線治療後に生じた直腸障害に関する考察2011

    • Author(s)
      高田康弘, 土井啓至, 冨士原将之, 田ノ岡征雄, 井上裕之, 三浦英治, 坪井慶太, 和泉正幸, 上紺屋憲彦, 廣田省三
    • Organizer
      日本放射線腫瘍学会第24回学術大会
    • Place of Presentation
      神戸
    • Related Report
      2011 Annual Research Report
  • [Presentation] 晩期放射線性直腸炎の動物実験モデル作成と病理組織学的検討2010

    • Author(s)
      土井啓至
    • Organizer
      日本放射線腫瘍学会第23回学術大会
    • Place of Presentation
      東京ベイ舞浜ホテルクラブリゾート(千葉)
    • Year and Date
      2010-11-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Efficacy of Polaprezinc to Acute Radiation Proctitis using an Animal Experimental Model.2010

    • Author(s)
      土井啓至
    • Organizer
      American Society for Radietion Oncology (ASTRO)
    • Place of Presentation
      San Diego Convention Center, San Diego, USA
    • Year and Date
      2010-11-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] 放射線治療に伴う粘膜障害は軽減できるか?-亜鉛製剤の有用性に迫る-2010

    • Author(s)
      上紺屋憲彦
    • Organizer
      第23回日本口腔・咽頭科学会総会
    • Place of Presentation
      京王プラザホテル(東京)
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Efficacy of Polaprezinc to Acute Radiation Proctitis using an experimental rat model.2010

    • Author(s)
      土井啓至
    • Organizer
      European Society for Therapeutic Radiation and Oncology (ESTRO)
    • Place of Presentation
      Barcelona International Convention Center, Barcelona, Spain
    • Year and Date
      2010-09-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] 放射線性直腸炎動物実験モデルに対する亜鉛製剤の有効性に関する組織学的検討2010

    • Author(s)
      土井啓至
    • Organizer
      第49回日本医学放射線学会生物部会学術大会
    • Place of Presentation
      ホテルさっぽろ芸文館(北海道)
    • Year and Date
      2010-07-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 動物実験モデルでの急性期放射線性直腸炎への亜鉛製剤の有効性2010

    • Author(s)
      土井啓至
    • Organizer
      第69回日本医学放射線学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Year and Date
      2010-04-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Efficacy of Polaprezinc to Acute Radiation Proctitis using an Animal Experimental Model2010

    • Author(s)
      Doi H、Kamikonya N、Takada Y、Fujiwara M、Inoue H、Tanooka M、Nakamura T、Shikata T, Tsujimura T、Hirota S
    • Organizer
      American Society for Radietion Oncology(ASTRO)
    • Place of Presentation
      San Diego
    • Related Report
      2011 Final Research Report
  • [Presentation] 放射線治療に伴う粘膜障害は軽減できるか2010

    • Author(s)
      上紺屋憲彦
    • Organizer
      第23回日本口腔・咽頭科学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Presentation] 放射線治療:消火器2.直腸2010

    • Author(s)
      上紺屋憲彦
    • Organizer
      第69回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] 放射線性直腸炎に対する亜鉛製剤経直腸投与の経験.2009

    • Author(s)
      土井啓至
    • Organizer
      日本放射線腫瘍学会第22回学術大会
    • Place of Presentation
      京都
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fundamental study of polaprezinc suppositories in the prevention of acute radiation proctitis in rats.2009

    • Author(s)
      上紺屋憲彦
    • Organizer
      欧州腫瘍学会
    • Place of Presentation
      ベルリン
    • Year and Date
      2009-09-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] 放射線性直腸炎に対する亜鉛製剤経直腸投与が有効であった症例.2009

    • Author(s)
      土井啓至
    • Organizer
      第292回日本医学放射線学会関西地方会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-04
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fundamental study of polaprezinc suppositories in the prevention of acute radiation proctitis in rats2009

    • Author(s)
      Kamikonya N、Doi H、Inoue H、Tanooka M、Takada Y、Fujiwara M、Tsuboi K、Hirota S、Shikata T、Kadobayashi M
    • Organizer
      ESMO
    • Place of Presentation
      Berlin
    • Related Report
      2011 Final Research Report
  • [Presentation] 放射線性直腸粘膜障害評価用の動物実験モデル作成と亜鉛製剤投与2009

    • Author(s)
      土井啓至
    • Organizer
      第68回日本医学放射線学会総会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report 2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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