Development of small-diameter vascular graft composed of antithrombogenic phospholipid polymer

• Project/Area Number: 21591628
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: The University of Tokyo
• Principal Investigator: OKAMOTO Hiroyuki 東京大学, 医学部附属病院, 助教 (60348266)
• Co-Investigator(Kenkyū-buntansha): KOYAMA Hiroyuki 東京大学, 医学部附属病院, 特任准教授 (10241994) ; MIYATA Tetsurou 東京大学, 医学部附属病院, 准教授 (70190791) ; SHIGEMATSU Kunihiro 東京大学, 医学部附属病院, 講師 (20215966) ; KIMURA Hideo 東京大学, 医学部附属病院, 助教 (60327070)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 小口径人工血管 / MPCポリマー / 抗血栓性

Research Abstract

The patency rates of carotid or femoral arterial bypass with MPC-coated and noncoated ePTFE grafts were 9/37(24%) and 14/37(38%) after one week ; 4/37(11%) and 6/37(15%) after two weeks ; and 3/37(8%) and 3/37(8%) after four weeks. Based on a histological examination, the thrombus was attached to the cut edges of the host artery. Intimal hyperplasia at the anastomosis and the surface of MPC-coated grafts was not changed remarkably compared with noncoated grafts.