| Project/Area Number |
21591636
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
UEMOTO Shinji 京都大学, 医学研究科, 教授 (40252449)
金宗 潤 京都大学, 医学研究科, 研究員 (10511925)
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| Co-Investigator(Renkei-kenkyūsha) |
HYON S-h 京都大学, 再生医科学研究所, 准教授 (90283655)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 膵島移植 / 免疫抑制 / 拒絶反応 / ポリフェノール / 糖尿病 / 抗原提示・認識 / 免疫カムフラージュ / アナジー / GVHD |
|---|
| Research Abstract |
We evaluated the immunological attenuation effects of a polyphenol(epigallocatechin gallate=EGCG) by mixed lymphocyte reaction assays and murine islet transplantation models. EGCG attenuated immunological reactions in allograft transplantations for both immunological rejection and graft-versus-host disease. In the rejection model, EGCG blocked CD28 and CD3_ε, rendering incomplete stimulation and subsequent apoptosis in the responder cells. EGCG by blocking similar co-stimulatory signals also attenuated the severity of GVHD. Taken together, EGCG was found to exhibit immunological attenuating effects and be a potential model compound for developing immune-suppression drugs in transplantation medicine.
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