Amelioration of lymphedema by extracorporeal low-energy shock wave therapy through promotion of lymphangiogenesis

• Project/Area Number: 21591639
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Yamaguchi University
• Principal Investigator: SHIRASAWA Bungo 山口大学, 医学部附属病院, 講師 (80444719)
• Co-Investigator(Kenkyū-buntansha): HAMANO Kimikazu 山口大学, 大学院・医学系研究科, 教授 (60263787) ; KUBO Masayuki 山口大学, 大学院・医学系研究科, 助教 (60420519)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: リンパ浮腫 / リンパ管新生 / 衝撃波 / VEGF-C / VEGFR3 / リンパ管 / 再生医療 / リンパ管再生

Research Abstract

Lymphedema is a common complication after surgical and radiation therapy for cancer, and therapeutic options for lymphedema are currently limited and largely ineffective. The purpose of this study was to develop the method of reducing lymphedema by extracorporeal low-energy shock wave, based on the induction of lymphangiogenesis. This study shows that extracorporeal low-energy shock wave therapy ameliorates lymphedema by enhancing the expression of VEGF-C and increasing the formation of lymphatic vessels, suggesting that extracorporeal shock wave therapy may be an effective and safe method for lymphedema.

Research Products

• [Journal Article] Extracorporeal shock wave therapy ameliorates secondary lymphedema by promoting lymphangiogenesis (2010)
  • Author(s): Kubo M, Li TS, Kamota T, Ohshima M, Shirasawa B, Hamano K
  • Journal Title: J Vasc Surg Volume: 52(2) Pages: 429-434
  • Peer Reviewed
• [Journal Article] Extracorporeal shock wave therapy ameliorates secondary lymphedema by promoting lymphangiogenesis (2010)
  • Author(s): Masayuki Kubo
  • Journal Title: Journal of Vascular Surgery Volume: 52(2) Pages: 429-434
  • Peer Reviewed
• [Journal Article] Extracorporeal shock wave therapy ameliorates secondary lymphedema by promoting lymphangiogenesis (2010)
  • Author(s): Masayuki Kubo
  • Journal Title: Journal of Vascular Surgery (in press)
  • Peer Reviewed
• [Presentation] 低出力衝撃波照射によるリンパ管再生に基づいたリンパ浮腫治療法の開発 (2011)
  • Author(s): 久保正幸, 李桃生, 鴨田隆弘, 大島真子, 白澤文吾, 濱野公一
  • Organizer: 第10回日本再生医療学会総会
  • Place of Presentation: 東京・京王プラザホテル
  • Year and Date: 2011-03-02