The enhancement of therapeutic efficacy of autologous cells by hypoxic preconditioning
| Project/Area Number |
21591640
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HAMANO Kimikazu 山口大学, 大学院・医学系研究科, 教授 (60263787)
KUBO Masayuki 山口大学, 大学院・医学系研究科, 助教 (60420519)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 血管新生 / 細胞移植 / 生着率 / 低酸素 / プレコンディショニング / 再生医療 / 末梢血単核球 |
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| Research Abstract |
Therapeutic angiogenesis by the implantation of autologous cells is a promising treatment for ischemic diseases. However, the poor retention of the cells after implantation into ischemic tissue is a major problem that related to poor potential of cell-based therapy. This study shows that hypoxic preconditioning enhances the therapeutic potential of implanted cells by increasing their retention. This approach is a short-term and simple method of enhancing the angiogenic potency of implanted cells. Further clinical trials are required to confirm the efficiency of this method.
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Report
(4 results)
Research Products
(12 results)
