Can we make a safe protocol for withdrawal from maintenanceimmunosupPressionafterlvertransplantaton?

• Project/Area Number: 21591642
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Kyushu University
• Principal Investigator: LICHエYAMA Hideakエ 九州大学, 大学病院, 特任講師 (70380425)
• Co-Investigator(Kenkyū-buntansha): NNOMYA Mizuki 九州大学, 大学病院, 特任助教 (30546461) ; KAYASHMA Hroto 九州大学, 医学研究院, 助教 (80546557)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 肝移植 / 免疫抑制剤 / 免疫寛容 / 拒絶反応 / HLA

Research Abstract

We tried to quantify the strength of rect piets' inmune responsesagai nst a respective donor in order to establish a safe protocol for withdrawal from inmunosuppressants after living donor liver transplantation. Reci pients' mixed 1ymphocyte reaction against a respective donor never wakened even long after liver transpl ant ation, which indicated that mixed 1ymphocyte reaction cannot be used as anindicator for recipients' imune reaction against donors. Oh the other hand, the more HLA misnatches between donors and recipients existed, the more graft wre lost. Recipients with high HLA misnatch should not reduce their dosages of imunosuppressants.

Research Products

• [Journal Article] Relevance of HLA compati bility in living donor liver transplantation The double edged sword associated with the patient out come
  • Author(s): Uchiyana H, Kayashina H, Matono R, Shirabe K, Yoshizumi T, Ikegami T, Soejina Y, Matsuura T, Taguchi T, Maehara Y
  • Journal Title: CIi ni cal Transplantation Volume: In press
  • Peer Reviewed
• [Presentation] Graft failure caused by chronic rejection after living donor liver transplantation : incidence and risk factors (2010)
  • Author(s): Hideaki Uchiyama
  • Organizer: The 8^<th> Japan-Korea Transplantation Forum
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2010-10-21
• [Presentation] XXIII International Congress of The Trannspl ant ation Society (2010)
  • Author(s): Uchiyana H, Shirabe K, Taketomi A, Soejina. Y, Ninomiya M, Kayashima H, Maehara Y
  • Organizer: Extra anatonical hepatic artery reconstruction in living donor liver transpl ant ation : lessons from 352 transplants
  • Place of Presentation: Vancouver, Canada
• [Presentation] The 8t' Japan Korea Trasp ant ation Forum (2010)
  • Author(s): Uchiyana H, Shirabe K, Taketomi A, Yoshi zumi T, Harda N, Ijichi H, Maehara Y
  • Organizer: Graft failure caused by chronic rejection after living donor liver transplantation : inci dence and risk factors
  • Place of Presentation: Kyoto, Japan
• [Presentation] 生体肝移植術後発症した代謝性疾患の検討 (2009)
  • Author(s): 武石一樹
  • Organizer: 第27回日本肝移植研究会
  • Place of Presentation: 静岡
  • Year and Date: 2009-07-10
• [Presentation] 生体肝移植後に発症した代謝性疾患の検討 (2009)
  • Author(s): 武石一樹、武冨紹信、戸島剛男、福原崇介、森田和豊、梅田健二、植田茂、井口友宏、實藤健作、永田茂行、杉町圭史、池上徹、祇園智信、副島雄二、前原喜彦
  • Organizer: 第27回日本肝移植研究会
  • Place of Presentation: 日静岡
• [Book] Microvascular hepatic artery reconstruction .In Liver Transplant ation Techni cal issues and conplications, edited by Abdel dayem Hand All am N (2012)
  • Author(s): Uchiyana H, Shiraba K, Taketomi A, Soejina Y, Yoshizumi T, Ikegani T, Harada N, Kayashina H, Maehara Y
  • Publisher: In Tech
• [Book] Liver Transplantation-Technical Issues and Complications (ISBN : 978-953-51-0015-7 Chapter 3 Microvascular hepatic artery reconstruction in living donor liver transplantation (2012)
  • Author(s): Hideaki Uchiyama
  • Total Pages: 18
  • Publisher: INTECH