| Project/Area Number |
21591644
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUDO Tomoya 九州大学, 大学病院, 助教 (50309803)
本村 誠一 九州大学, 生体防御医学研究所, 助教 (40304828)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 癌幹細胞 / 細胞周期 / 肝細胞 / 癌特異的免疫療法 / ガンマデルタT細胞 / 癌肝細胞 |
|---|
| Research Abstract |
We reported the presence of cancer stem cells(CSS), showing the characters of self-renew and multi-potential deviation, in gastrointestinal cancer. Toward the cancer therapy, complete control of cancer cells would be obtained targeting cancer stem cells. We reported in this study that CD13 as cancer stem cell marker. Using MH129 cells(C3H derived HCC), we achieved that antitumor effect. A prevention method, such as injection of CSS before inoculation of MH129 cells, antitumor effect was observed.
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