Development of cancer stem cell specific therapy using gannma-delta T cells and dendritic cells
Project/Area Number |
21591644
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General surgery
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Research Institution | Kyushu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
SUDO Tomoya 九州大学, 大学病院, 助教 (50309803)
本村 誠一 九州大学, 生体防御医学研究所, 助教 (40304828)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | 癌幹細胞 / 細胞周期 / 肝細胞 / 癌特異的免疫療法 / ガンマデルタT細胞 / 癌肝細胞 |
Research Abstract |
We reported the presence of cancer stem cells(CSS), showing the characters of self-renew and multi-potential deviation, in gastrointestinal cancer. Toward the cancer therapy, complete control of cancer cells would be obtained targeting cancer stem cells. We reported in this study that CD13 as cancer stem cell marker. Using MH129 cells(C3H derived HCC), we achieved that antitumor effect. A prevention method, such as injection of CSS before inoculation of MH129 cells, antitumor effect was observed.
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Report
(4 results)
Research Products
(83 results)
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[Journal Article] Down-regulation of miR-125a-3p in human gastric cancer and its clinicopathological significance2012
Author(s)
Yojiro Hashiguchi, Naohiro Nishida, Koshi Mimori, Tomoya Sudo, Fumiaki Tanaka, Kohei Shibata, Hideshi Ishii, Hidetaka Mochizuki, Kazuo Hase, Yuichiro Doki, Masaki Mori
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Journal Title
Int J Oncol
Volume: 40(5)
Pages: 1477-82
DOI
Related Report
Peer Reviewed
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[Journal Article] MicroRNA-125a-5p is an independent prognostic factor in gastric cancer, and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab2011
Author(s)
Nishida N, Mimori K, Fabbri M, Yokobori T, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Mori M.]
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Journal Title
Clin Cancer Res
Volume: 17(9)
Pages: 2725-33
DOI
Related Report
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[Journal Article] Kinesin 18A expression clinical relevance to colorectal cancer progression2011
Author(s)
Nagahara M, Nishida N, Iwatsuki M, Ishimaru S, Mimori K, Tanaka F, Nakagawa T, Sato T, Sugihara K, Hoon DS, Mori M.
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Journal Title
Int J Cancer
Volume: 129(11)
Pages: 2543-52
DOI
Related Report
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[Journal Article] Kinesin 18A expression clinical relevance to colorectal cancer progression2011
Author(s)
Nagahara M, Nishida N, Iwatsuki M, Ishimaru S, Mimori K, Tanaka F, Nakagawa T, Sato T, Sugihara K, Hoon DS, Mori M
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Journal Title
Int J Cancer
Volume: 129
Pages: 2543-52
DOI
Related Report
Peer Reviewed
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[Journal Article] Long Noncoding RNA HOTAIR Regulates Polycomb-Dependent Chromatin Modification and Is Associated with Poor Prognosis in Colorectal Cancers2011
Author(s)
Kogo R, Shimamura T, Mimori K, Kawahara K, Imoto S, Sudo T, Tanaka F, Shibata K, Suzuki A, Komune S, Miyano S, Mori M
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Journal Title
Cancer Res
Volume: 71
Pages: 6320-6
DOI
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Peer Reviewed
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[Journal Article] Reprogramming of Mouse and Human Cells to Pluripotency Using Mature MicroRNAs2011
Author(s)
Miyoshi N, Ishii H, Nagano H, Haraguchi N, Dewi DL,Kano Y, Nishikawa S, Tanemura M, Mimori K, Tanaka F, Saito T, Nishimura J, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Sekimoto M, Doki Y, Mori M
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Journal Title
Cell Stem Cell
Volume: 8
Pages: 633-8
DOI
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Peer Reviewed
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[Journal Article] MicroRNA-125a-5p is an independent prognostic factor in gastric cancer, and inhibits the proliferation of human gastric cancer cells in combination with trastuzumab.2011
Author(s)
Nishida N, Mimori K, Fabbri M, Yokobori T, Sudo T, Tanaka F, Shibata K, Ishii H, Doki Y, Mori M.
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Journal Title
Clin Cancer Res
Volume: (Epub)
Related Report
Peer Reviewed
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[Journal Article] Kinesin 18A expression clinical relevance to colorectal cancer progression.2011
Author(s)
Nagahara M, Nishida N, Iwatsuki M, Ishimaru S, Mimori K, Tanaka F, Nakagawa T, Sato T, Sugihara K, Hoon DS, Mori M.
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Journal Title
Int J Cancer
Volume: (Epub)
Related Report
Peer Reviewed
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[Journal Article] Clinical Significance of Stanniocalcin 2 as a Prognostic Marker in Gastric Cancer2010
Author(s)
Yokobori T, Mimori K, Ishii H, Iwatsuki M, Tanaka F, Kamohara Y, Ieta K, Kita Y, Doki Y, Kuwano H, Mori M.'
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Journal Title
Ann Surg Oncol
Volume: 17(10)
Pages: 2601-7
DOI
Related Report
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[Journal Article] CD13 is a therapeutic target in human liver cancer stem cells2010
Author(s)
Haraguchi N, Ishii H, Mimori K, Tanaka F, Ohkuma M, Kim HM, Akita H, Takiuchi D, Hatano H, Nagano H, Barnard GF, Doki Y, Mori M.
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Journal Title
J Clin Invest
Volume: 120(9)
Pages: 3326-39
DOI
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[Journal Article] Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles2010
Author(s)
Tanaka F, Yamamoto K, Suzuki S, Inoue H, Tsurumaru M, Kajiyama Y, Kato H, Igaki H, Furuta K, Fujita H, Tanaka T, Tanaka Y, Kawashima Y, Natsugoe S, Setoyama T, Tokudome S, Mimori K, Haraguchi N, Ishii H, Mori M.
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Journal Title
Gut
Volume: 59(11)
Pages: 1457-64
Related Report
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[Journal Article] Strong interaction between the effects of alcohol consumption and smoking on oesophageal squamous cell carcinoma among individuals with ADH1B and/or ALDH2 risk alleles.2010
Author(s)
Tanaka F, Yamamoto K, Suzuki S, Inoue H, Tsurumaru M, Kajiyama Y, Kato H, Igaki H, Furuto K, Fujita H, Tanaka T, Tanaka Y, Kawashima Y, Natsugoe S, Setoyama T, Tokudome S, Mimori K, Haraguchi N, Ishii H, Mori M
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Journal Title
Gut.
Volume: 59
Pages: 1457-64
Related Report
Peer Reviewed
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[Journal Article] CD13 is a therapeutic target in human liver cancer stem cells.2010
Author(s)
Haraguchi N, Ishii H, Mimori K, Tanaka F, Ohkuma M, Kim HM, Akita H, Takiuchi D, Hatano H, Nagano H, Barnard GF, Doki Y, Mori M.
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Journal Title
J Clin Invest
Volume: 120
Pages: 3326-9
Related Report
Peer Reviewed
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[Journal Article] Clinical Significance of Stanniocalcin 2 as a Prognostic Marker in Gastric Cancer.2010
Author(s)
Yokobori T, Mimori K, Ishii H, Iwatsuki M, Tanaka F, Kamohara Y, Ieta K, Kita Y, Doki Y, Kuwano H, Mori M.
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Journal Title
Ann Surg Oncol
Volume: 17
Pages: 2601-7
Related Report
Peer Reviewed
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[Journal Article] Clinicopathological significance of stanniocalcin 2 gene expression in colorectal cancer2009
Author(s)
Ieta K, Tanaka F, Yokobori T, Kita Y, Haraguchi N, Mimori K, Kato H, Asao T, Inoue H, Kuwano H, Mori M.
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Journal Title
Int J Cancer
Volume: 125(4)
Pages: 926-31
DOI
Related Report
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[Journal Article] Clinical significance of LAMB3 and COL7A1 mRNA in esophageal squamous cell carcinoma2009
Author(s)
Kita Y, Mimori K, Tanaka F, Matsumoto T, Haraguchi N, Ishikawa K, Matsuzaki S, Fukuyoshi Y, Inoue H, Natsugoe S, Aikou T, Mori M.
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Journal Title
Eur J Surg Oncol
Volume: 35(1)
Pages: 52-8
DOI
Related Report
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[Journal Article] Clinicopathological significance of stanniocalcin 2 gene expression in colorectal cancer2009
Author(s)
Ieta K, Tanaka F, Yokobori T, Kita Y, Haraguchi N, Mimori K, Kato H, Asao T, Inoue H, Kuwano H, Mori M
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Journal Title
Int J Cancer 125
Pages: 926-31
Related Report
Peer Reviewed
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[Journal Article] A platinum agent resistance gene, POLB, is a prognostic indicator in colorectal cancer2009
Author(s)
Iwatsuki M, Mimori K, Yokobori T, Tanaka F, Tahara K, Inoue H, Baba H, Mori M.
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Journal Title
A platinum agent resistance gene, POLB, is a prognostic indicator in colorectal cancer 100
Pages: 261-6
Related Report
Peer Reviewed
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[Journal Article] Clinical significance of LAMB3 and COL7Al mRNA in esophageal squamous cell carcinoma2009
Author(s)
Kita Y, Mimori K, Tanaka F, Matsumoto T, Haraguchi N, Ishikawa K, Matsuzaki S, Fukuyoshi Y, Inoue H, Natsugoe S, Aikou T, Mon M.
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Journal Title
Eur J Surg Oneol. 35
Pages: 52-8
Related Report
Peer Reviewed
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