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Development of stem cell transplantation with enteric nervous differentiation from mouse pluripotent stem cells under microgravity

Research Project

Project/Area Number 21591649
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionNara Medical University

Principal Investigator

UEDA Takeshi (2010-2011)  奈良県立医科大学, 医学部附属病院, 研究員 (40526810)

山田 高嗣 (2009)  Nara Medical University, 医学部, 助教 (20316061)

Co-Investigator(Kenkyū-buntansha) KANEHIRO Hiromichi  奈良県立医科大学, 医学部, 准教授 (30204580)
植田 剛  奈良県立医科大学, 医学部附属病院, 医員 (40526810)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords人工臓器学 / 再生医学 / 幹細胞 / 細胞・臓器移植 / 多能性幹細胞 / ES細胞 / iPS細胞 / 腸管分化誘導 / 神経堤幹細胞 / 脂肪由来幹細胞
Research Abstract

For new stem cell transplantation by using spheroid derived from neural crest stem cells and adipose tissue-derived stem cells under microgravity, at first, we tried to perform the differentiation from induced pluripotent stem cells to the neural crest stem cell. We demonstrate that mouse iPS cells have the ability to organize a gut-like organ with motor function in vitro by three-dementional culture. A gut-like organ was composed of all the enteric components of three germ layers. When this study aims for treatment of Hirschsprung's disease, it was very important discovery to organization of functional gut including the nervous system from iPS cells which have a disease-specific characteristic.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (14 results)

All 2010 2009

All Journal Article (4 results) (of which Peer Reviewed: 1 results) Presentation (6 results) Book (1 results) Patent(Industrial Property Rights) (3 results)

  • [Journal Article] Generation of functional gut-like organ from mouse induced pluripotent stem cells2010

    • Author(s)
      Ueda T, Yamada T Kanehiro H, Nakajima Y, et al
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 391 Pages: 38-42

    • Related Report
      2011 Final Research Report
  • [Journal Article] iPS細胞から蠕動運動する腸管の作成2010

    • Author(s)
      植田剛, 中島祥介
    • Journal Title

      感染・免疫・炎症

      Volume: 40 Pages: 80-82

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] 腸管再生医療の現状と展望-iPS細胞からの腸管再生-2010

    • Author(s)
      植田剛, 中島祥介
    • Journal Title

      大腸癌フロンティア

      Volume: 3 Pages: 75-79

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Generation of functional gut-like organ from mouse induced pluripotent stem cells2010

    • Author(s)
      UEDA T
    • Journal Title

      Biochem Biophys Res Commun 391

      Pages: 38-42

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] iPS細胞から蠕動する人工腸管(iGut)への臓器分化誘導2010

    • Author(s)
      植田剛
    • Organizer
      第65回日本消化器外科学会
    • Place of Presentation
      下関市生涯学習プラザ
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] iPS細胞から蠕動運動する腸管(iGut)への臓器分化誘導2010

    • Author(s)
      植田剛
    • Organizer
      第110回日本外科学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2010-04-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] iPS細胞から蠕動運動する腸管(iGut)への臓器分化誘導2010

    • Author(s)
      植田剛
    • Organizer
      第9回日本再生医療学会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2010-03-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] iPS細胞から蠕動運動する腸管(iGut)への臓器分化誘導2010

    • Author(s)
      植田剛、山田高嗣、中島祥介
    • Organizer
      第9回日本再生医療学会
    • Place of Presentation
      広島
    • Related Report
      2011 Final Research Report
  • [Presentation] iPS細胞から蠕動運動する腸管(iGut)への臓器分化誘導2010

    • Author(s)
      植田剛、山田高嗣、中島祥介
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] iPS細胞から蠕動する人工腸管(iGut)への臓器分化誘導2010

    • Author(s)
      植田剛、山田高嗣、中島祥介
    • Organizer
      第65回日本消化器外科学会総会
    • Place of Presentation
      下関
    • Related Report
      2011 Final Research Report
  • [Book] 分子細胞治療フロンティア2010

    • Author(s)
      植田剛, 山田高嗣, 小山文一, 金廣裕道, 中島祥介
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 人工腸管の作成法2009

    • Inventor(s)
      山田高嗣
    • Industrial Property Rights Holder
      奈良医大
    • Filing Date
      2009-06-10
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 人工腸管の作製法2009

    • Inventor(s)
      山田高嗣
    • Industrial Property Rights Holder
      奈良医大
    • Filing Date
      2009-06-01
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 人工腸管の作製法2009

    • Inventor(s)
      山田高嗣
    • Industrial Property Rights Holder
      奈良医大
    • Filing Date
      2009-06-01
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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