| Project/Area Number |
21591653
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
General surgery
|
|---|
| Research Institution | Department of Clinical Research, National Hospital Organization Mito Medical Center |
|---|
Principal Investigator |
YUZAWA Kenji 独立行政法人国立病院機構水戸医療センター(臨床研究部), 移植医療研究室, 室長 (10240160)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HOMMA Masato 筑波大学, 人間総合科学研究科臨床薬理学, 准教授 (90199589)
|
|---|
| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 移植外科学 / 臓器移植 / 免疫抑制 / オーダーメイド医療 / 腎臓移植 / 薬剤代謝 / 遺伝子多型 / オーダーメイド療法 / 薬物代謝 |
|---|
| Research Abstract |
Now, immunosuppressive therapies for organ transplanted patients are uniform. This study was performed to establish the personalized immunosuppressive therapy for the patients. We evaluated the relationship among blood concentration of the drugs, drug dosage, gene polymorphism of drug metabolism, immunosuppressive status measured by ImmuKnow, period after transplantation and age. We could not obtain significant relationship among these factors. It seemed to be necessary to evaluate more patients, more polymorphism, more accurate measurement of immunosuppressive status.
|
