Basic study for establishment for personalized immunosuppressive therapy for organ transplantation

• Project/Area Number: 21591653
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Department of Clinical Research, National Hospital Organization Mito Medical Center
• Principal Investigator: YUZAWA Kenji 独立行政法人国立病院機構水戸医療センター(臨床研究部), 移植医療研究室, 室長 (10240160)
• Co-Investigator(Kenkyū-buntansha): HOMMA Masato 筑波大学, 人間総合科学研究科臨床薬理学, 准教授 (90199589)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 移植外科学 / 臓器移植 / 免疫抑制 / オーダーメイド医療 / 腎臓移植 / 薬剤代謝 / 遺伝子多型 / オーダーメイド療法 / 薬物代謝

Research Abstract

Now, immunosuppressive therapies for organ transplanted patients are uniform. This study was performed to establish the personalized immunosuppressive therapy for the patients. We evaluated the relationship among blood concentration of the drugs, drug dosage, gene polymorphism of drug metabolism, immunosuppressive status measured by ImmuKnow, period after transplantation and age. We could not obtain significant relationship among these factors. It seemed to be necessary to evaluate more patients, more polymorphism, more accurate measurement of immunosuppressive status.

Research Products

• [Journal Article] A simplechromatographic method for determiningnorfloxacin and enoxacin inpharmacokinetic study assessing CYP1A2 inhibition (2011)
  • Author(s): Kobayashi T, Homma M, Momo K, Kobayashi D, Kohda Y.
  • Journal Title: Biomed Chromatogr Volume: Vol.25、No.4 Pages: 435-438
  • Peer Reviewed
• [Journal Article] 腎移植におけるミゾリビン高用量使用の経験 (2010)
  • Author(s): 湯沢賢治
  • Journal Title: 今日の移植 Volume: 18巻 Pages: 403-409
  • Peer Reviewed
• [Journal Article] Difference in blood tacrolimusconcentration between ACMIA and MEIAin samples with low haematocrit values (2010)
  • Author(s): Doki K, Homma M, Hori T, Tomita T, Hasegawa Y, Ito S, Fukunaga K, Kaneko M, Chiba S, Sumida T, Ohkohchi N, Kohda Y.
  • Journal Title: J Pharm Pharmacol Volume: Vol62, No9 Pages: 1185-1188
  • Peer Reviewed
• [Journal Article] Open-well stability of reagent cartridge foraffinity column-mediated immunoassay ofblood tacrolimus concentration (2010)
  • Author(s): Doki K, Homma M, Kohda Y.
  • Journal Title: Clin Chim Acta Volume: Vol.411, No.11-12 Pages: 888-889
  • Peer Reviewed
• [Journal Article] Effects ofmexiletine, a CYP1A2 inhibitor, ontizanidine pharmacokinetics andpharmacodynamics (2010)
  • Author(s): Momo K, Homma M, Osaka Y, Inomata S, Tanaka M, Kohda Y.
  • Journal Title: J Clin Pharmacol Volume: Vol.50, No.3 Pages: 331-337
  • Peer Reviewed
• [Journal Article] Effects of CYP2D6 genotypeson age-related change of flecainidemetabolism : involvement ofCYP1A2-mediated metabolism (2009)
  • Author(s): Doki K, Homma M, Kuga K, AonumaK, Kohda Y.
  • Journal Title: Br J Clin Pharmacol Volume: Vol.68, No.1 Pages: 89-96
  • Peer Reviewed
• [Presentation] フレカイニドのTDMにおけるCYP2D6とSCN5A遺伝子多型解析 (2010)
  • Author(s): 本間真人、土岐浩介、青沼和隆、幸田幸直
  • Organizer: 第20回日本医療薬学
  • Place of Presentation: 千葉市
• [Presentation] 末梢血リンパ球SLC29A1mRNA発現にSLC29A1遺伝子多型が与える影響 (2009)
  • Author(s): 鈴木嘉治,本間真人,幸田幸直
  • Organizer: 第19回日本医療薬学会
  • Place of Presentation: 長崎市
• [Book] 薬物療法に寄与する臨床薬剤学、薬剤学 (2012)
  • Author(s): 幸田幸直,本間真人
• [Book] 医薬品適正使用を目指した薬物相互作用・副作用症例の解析研究、医療薬学 (2012)
  • Author(s): 本間真人
• [Book] 免疫抑制薬のTDM標準化に向けた中間報告、TDM研究 (2011)
  • Author(s): 増田智先,村木優一,竹内裕紀,葛谷孝文,本間真人
• [Book] 腎移植における高用量ミゾリビン併用療法、今日の移植 (2009)
  • Author(s): 湯沢賢治