Evaluation of improvement of vascularization for transplanted islet with PBSCs
| Project/Area Number |
21591654
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Clinical research Center, Chiba-East National Hospital, National Hospital Organization |
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Principal Investigator |
ITO Taihei 独立行政法人国立病院機構(千葉東病院臨床研究センター) (60509701)
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| Co-Investigator(Kenkyū-buntansha) |
KENMOCHI Takashi 独立行政法人国立病院機構(千葉東病院臨床研究センター), 臨床研究センター, センタ長 (50215133)
MARUYAMA Michihiro 独立行政法人国立病院機構(千葉東病院臨床研究センター), 分子生物研究室, 室長 (40399754)
AKUTSU Naotake 独立行政法人国立病院機構(千葉東病院臨床研究センター), 移植再生医療研究部, 部長 (00344979)
OTSUKI Kazunori 独立行政法人国立病院機構(千葉東病院臨床研究センター), 実験治療開発研究室, 室長 (50399755)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 膵島移植 / 血管再生医療 / 末梢血幹細胞 / 糖尿病 / 間葉系幹細胞 |
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| Research Abstract |
In this study we established culture of both PBSCs and MSCs from canine. Now, we are trying to establish canine islet transplantation modelwith marginal number and compare between those control model and PBSCs or MSCsco-transplant model in terms of glucose tolerance.
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Report
(4 results)
Research Products
(47 results)
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[Journal Article] Quantitative assessment ofβ-cell apoptosis and cell compositionof isolated, undisrupted human islets bylaser scanning cytometry2010
Author(s)
Todorov I, Nair I, Avakian-MansoorianA, Rawson J, Omori K, Ito T, Valiente L, Iglesias-Meza I, Orr C, Shiang KD, Ferreri K, Al-Abdullah IH, Mullen Y, Kandeel F.
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Journal Title
Transplantation
Volume: 90(8)
Pages: 836-42
Related Report
Peer Reviewed
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[Presentation] A new viability assay of isletusing WST-1/DNA2010
Author(s)
Taihei Ito, Takashi Kenmochi, Michihiro Maruyama, Kenichi Saigo, Naotake Akutsu, Chikara Iwashita, Kazunori Otsuki, Saito Tomonori, Takehide Asano
Organizer
XXIII International Congress of The Transplantation
Place of Presentation
Vancouver, Canada
Year and Date
2010-08-16
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