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Evaluation of improvement of vascularization for transplanted islet with PBSCs

Research Project

Project/Area Number 21591654
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionClinical research Center, Chiba-East National Hospital, National Hospital Organization

Principal Investigator

ITO Taihei  独立行政法人国立病院機構(千葉東病院臨床研究センター) (60509701)

Co-Investigator(Kenkyū-buntansha) KENMOCHI Takashi  独立行政法人国立病院機構(千葉東病院臨床研究センター), 臨床研究センター, センタ長 (50215133)
MARUYAMA Michihiro  独立行政法人国立病院機構(千葉東病院臨床研究センター), 分子生物研究室, 室長 (40399754)
AKUTSU Naotake  独立行政法人国立病院機構(千葉東病院臨床研究センター), 移植再生医療研究部, 部長 (00344979)
OTSUKI Kazunori  独立行政法人国立病院機構(千葉東病院臨床研究センター), 実験治療開発研究室, 室長 (50399755)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords膵島移植 / 血管再生医療 / 末梢血幹細胞 / 糖尿病 / 間葉系幹細胞
Research Abstract

In this study we established culture of both PBSCs and MSCs from canine. Now, we are trying to establish canine islet transplantation modelwith marginal number and compare between those control model and PBSCs or MSCsco-transplant model in terms of glucose tolerance.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (47 results)

All 2012 2011 2010 2009 Other

All Journal Article (6 results) (of which Peer Reviewed: 4 results) Presentation (41 results)

  • [Journal Article] Mesenchymal stemcells facilitate mixed hematopoieticchimerism induction and prevent onset ofdiabetes in nonobese diabetic mice2011

    • Author(s)
      Asari S, Itakura S, Rawson J, Ito T, Todorov I, Nair I, Shintaku J, Liu CP, Kandeel F, Mullen YS
    • Journal Title

      Pancreas

      Volume: 40(6) Pages: 846-54

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal stemcell and islet co-transplantationpromotes graft revascularization andfunction2010

    • Author(s)
      Ito T, Itakura S, Todorov I, Rawson J, Asari S, Shintaku J, Nair I, Ferreri K, Kandeel F, Mullen Y.
    • Journal Title

      Transplantation

      Volume: 89(12) Pages: 1438-45

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative assessment ofβ-cell apoptosis and cell compositionof isolated, undisrupted human islets bylaser scanning cytometry2010

    • Author(s)
      Todorov I, Nair I, Avakian-MansoorianA, Rawson J, Omori K, Ito T, Valiente L, Iglesias-Meza I, Orr C, Shiang KD, Ferreri K, Al-Abdullah IH, Mullen Y, Kandeel F.
    • Journal Title

      Transplantation

      Volume: 90(8) Pages: 836-42

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mesenchymal stem cell and islet co-transplantation promotes graft revas cularization and function.2010

    • Author(s)
      Taihei Ito
    • Journal Title

      Transplantation

      Volume: 89(12) Pages: 1438-1445

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 生体腎移植後のBKウイルス腎症に対しシドフォビルが著効した1例2010

    • Author(s)
      伊藤泰平
    • Journal Title

      今日の移植

      Volume: 23(6) Pages: 760-763

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 腎移植後早期にネフローゼ症候群を呈した再発腎炎の2例2009

    • Author(s)
      伊藤泰平
    • Journal Title

      今日の移植 22(6)

      Pages: 714-722

    • Related Report
      2009 Annual Research Report
  • [Presentation] 肝臓摘出断念後、膵臓摘出に至った脳死下膵腎同時移植症例の成績2012

    • Author(s)
      伊藤泰平
    • Organizer
      第39回日本膵膵島移植研究会
    • Place of Presentation
      旭川
    • Year and Date
      2012-03-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] ASOによる著名な動脈石灰化を有し、右大腿動脈バイパス後、左総腸骨動脈ステント留置後のレシピエントに施行した脳死膵腎同時移植の1例2012

    • Author(s)
      伊藤泰平
    • Organizer
      第39回日本膵膵島移植研究会
    • Place of Presentation
      旭川
    • Year and Date
      2012-03-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] 当院におけるPTLDに対する診療2012

    • Author(s)
      伊藤泰平
    • Organizer
      第45回日本臨床腎移植学会
    • Place of Presentation
      軽井沢
    • Year and Date
      2012-02-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腎移植における低用量タクロリムス免疫抑制プロトコールの有用性の検討2012

    • Author(s)
      伊藤泰平
    • Organizer
      第45回日本臨床腎移植学会
    • Place of Presentation
      軽井沢
    • Year and Date
      2012-02-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] EBV未感染者の腎移植後血中EBV-DNAモニタリングの有用性2011

    • Author(s)
      伊藤泰平
    • Organizer
      第23回腎移植免疫研究会
    • Place of Presentation
      大阪
    • Year and Date
      2011-10-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 当院における結核患者の消化器外科手術の検討2011

    • Author(s)
      伊藤泰平
    • Organizer
      第65回国立病院総合医学会
    • Place of Presentation
      岡山
    • Year and Date
      2011-10-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 当科における巣状糸球体硬化症(FSGS)に対する腎移植2011

    • Author(s)
      伊藤泰平
    • Organizer
      第44回日本移植学会
    • Place of Presentation
      仙台
    • Year and Date
      2011-10-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Prospective monitoring and therapy for BK virus nephropathy (BKN) in renal transplantation2011

    • Author(s)
      Taihei Ito
    • Organizer
      2th Congress of the Asian Society of Transplantation
    • Place of Presentation
      Soul, Korea
    • Year and Date
      2011-09-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] UW solution improves islet yield as a solution for pancreatic duct2011

    • Author(s)
      Taihei Ito
    • Organizer
      2th Congress of the Asian Society of Transplantation
    • Place of Presentation
      Soul, Korea
    • Year and Date
      2011-09-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 当院におけるABO不適合生体膵腎同時移植術2011

    • Author(s)
      伊藤泰平
    • Organizer
      第18回ABO不適合移植研究会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-07-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Charcot-Marie-Tooth病に合併した腎不全対し腎移植を施行した一例2011

    • Author(s)
      伊藤泰平
    • Organizer
      第20回日本腎不全外科研究会
    • Place of Presentation
      横浜
    • Year and Date
      2011-07-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 当科における生体膵腎同時移植術時の膵膀胱吻合の工夫2011

    • Author(s)
      伊藤泰平
    • Organizer
      第62回千葉県外科医会
    • Place of Presentation
      千葉
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 当科における腎移植後BKウイルス感染症2011

    • Author(s)
      伊藤泰平
    • Organizer
      第27回腎移植血管外科研究会
    • Place of Presentation
      札幌
    • Year and Date
      2011-06-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 膵島分離における膵臓保存時の膵管内注入保存液の検討2011

    • Author(s)
      伊藤泰平、剣持敬、西郷健一、丸山通広、圷尚武、大月和宣、岩下力、齋藤友永、浅野武秀
    • Organizer
      第38回日本膵膵島移植学会
    • Place of Presentation
      奈良
    • Year and Date
      2011-03-04
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 拒絶反応に抗ヒト胸腺細胞ウサギ免疫グロブリンが奏功した2例2011

    • Author(s)
      伊藤泰平
    • Organizer
      第44回日本臨床腎移植学会
    • Place of Presentation
      宝塚
    • Year and Date
      2011-01-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 生体腎移植後静脈血栓症に対し、移植腎摘出、再灌流、対側腸骨窩再移植にてgraftectomyを回避してた1例2010

    • Author(s)
      伊藤泰平
    • Organizer
      第7回臓器不全患者に対する外科・管理研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-11-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Simultaneous Pancreas and Kidney Transplantation from Living donorsin Japan.2010

    • Author(s)
      Taihei Ito
    • Organizer
      The 8th Japan-Korea Transplantation Forum
    • Place of Presentation
      京都
    • Year and Date
      2010-10-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 膵島移植におけるMesenchymal stem cells(MSCs)を用いたGene delivery system2010

    • Author(s)
      伊藤泰平
    • Organizer
      第46回日本移植学会
    • Place of Presentation
      京都
    • Year and Date
      2010-10-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] A new viability assay of isletusing WST-1/DNA2010

    • Author(s)
      Taihei Ito, Takashi Kenmochi, Michihiro Maruyama, Kenichi Saigo, Naotake Akutsu, Chikara Iwashita, Kazunori Otsuki, Saito Tomonori, Takehide Asano
    • Organizer
      XXIII International Congress of The Transplantation
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2010-08-16
    • Related Report
      2011 Final Research Report
  • [Presentation] A new viability assay of islet using WST-1/DNA2010

    • Author(s)
      Taihei Ito
    • Organizer
      XXIII International Congress of The Transplantation
    • Place of Presentation
      Vancouver, Canada
    • Year and Date
      2010-08-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 腎移植直後より高度蛋白尿を呈し、血漿交換にて軽快した1例2010

    • Author(s)
      伊藤泰平
    • Organizer
      第14回移植腎病理研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-07-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] 当院における結核患者の消化器外科手術2010

    • Author(s)
      伊藤泰平
    • Organizer
      第65回日本消化器外科学会
    • Place of Presentation
      下関
    • Year and Date
      2010-07-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] 当科で経験した腎移植後動静脈血栓症2010

    • Author(s)
      伊藤泰平
    • Organizer
      第26回腎移植・血管外科研究会
    • Place of Presentation
      犬山
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] 当科で経験した腎移植後BKウイルス感染症の2例2010

    • Author(s)
      伊藤泰平
    • Organizer
      第16回日本移植薬物療法研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-06-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] WST-1による新しい膵島viability assay2010

    • Author(s)
      伊藤泰平
    • Organizer
      第22回日本肝胆膵外科学会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 当院における膵腎同時移植手術2010

    • Author(s)
      伊藤泰平
    • Organizer
      第58回千葉県外科医会
    • Place of Presentation
      千葉
    • Year and Date
      2010-03-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] WST-1/DNA assayによる膵島viability測定2010

    • Author(s)
      伊藤泰平,剣持敬,西郷健一,丸山通広,圷尚武,大月和宣,岩下力,齊藤友永
    • Organizer
      第37回膵膵島移植学会
    • Place of Presentation
      宇都宮
    • Related Report
      2011 Final Research Report
  • [Presentation] Canine Mesenchymal Stem Cell(cMSCs)の分離・培養-大動物膵島移植実験への応用にむけて-2010

    • Author(s)
      斉藤友永、剣持敬、伊藤泰平、西郷健一、丸山通広、圷尚武、岩下力、大月和宣、浅野武秀
    • Organizer
      第46回日本移植学会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] 膵島移植におけるMesenchymalstem cells(MSCs)を用いたGenedelivery system2010

    • Author(s)
      伊藤泰平、剣持敬、西郷健一、丸山通広、圷尚武、大月和宣、岩下力、齋藤友永、浅野武秀
    • Organizer
      第46回日本移植学会
    • Place of Presentation
      京都
    • Related Report
      2011 Final Research Report
  • [Presentation] イヌ膵島移植モデルへの応用に向けたイヌ間葉系幹細胞(cMSC)の分離、培養2010

    • Author(s)
      斉藤友永、剣持敬、伊藤泰平、西郷健一、丸山通広、圷尚武、岩下力、大月和宣、浅野武秀
    • Organizer
      第37回日本臓器保存生物医学会
    • Place of Presentation
      新潟
    • Related Report
      2011 Final Research Report
  • [Presentation] 腎移植後早期に高度蛋白尿を呈した再発腎炎の2例2010

    • Author(s)
      伊藤泰平
    • Organizer
      第43回日本臨床腎移植学会
    • Place of Presentation
      高知
    • Related Report
      2009 Annual Research Report
  • [Presentation] WST-1/DNA assay による膵島 viability 測定2010

    • Author(s)
      伊藤泰平
    • Organizer
      第37回膵膵島移植学会
    • Place of Presentation
      宇都宮
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生体腎移植後の動脈血栓症に対して血栓除去、動脈再吻合を施行し、graftectomy を回避しえた1例2009

    • Author(s)
      伊藤泰平
    • Organizer
      第6回臓器不全患者に対する外科・管理研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] 腎移植後早期にネフローゼ症候群を呈した再発腎炎の2例2009

    • Author(s)
      伊藤泰平
    • Organizer
      第15回移植薬物療法研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-06-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] The application of luciferase transgenicrats for experimental islettransplantation model2009

    • Author(s)
      Taihei Ito、Takashi Kenmochi、KennichiSaigo、Michihiro Maruyama、NaotakeAkutsu、Kazunori Ohtsuki、ChikaraIwashita、Eiji Kobayashi、Takehide Asano
    • Organizer
      IPITA-IXA2009
    • Place of Presentation
      Venis, Italy
    • Related Report
      2011 Final Research Report
  • [Presentation] The application of luciferase transgenic rats for experimental islet transplantation model2009

    • Author(s)
      伊藤泰平
    • Organizer
      IPITA-IXA
    • Place of Presentation
      Venis, Italy
    • Related Report
      2009 Annual Research Report
  • [Presentation] 特発性胆嚢穿孔の一例2009

    • Author(s)
      伊藤泰平
    • Organizer
      第21回日本肝胆膵外科学会
    • Place of Presentation
      名古屋
    • Related Report
      2009 Annual Research Report
  • [Presentation] SLEに合併した小腸穿孔の2例2009

    • Author(s)
      伊藤泰平
    • Organizer
      第64回日本消化器外科学会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 生体部分膵移植に対する血栓形成の機序と対策―当施設の血栓予防プロトコール―2009

    • Author(s)
      伊藤泰平
    • Organizer
      第45回日本移植学会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] SLEに合併した消化管穿孔の2例2009

    • Author(s)
      伊藤泰平
    • Organizer
      第71回日本臨床外科学会
    • Place of Presentation
      京都
    • Related Report
      2009 Annual Research Report
  • [Presentation] UW solution improvesislet yield as a solution forpancreatic duct preservationbetter than ET-Kyoto solution

    • Author(s)
      Taihei Ito、TakashiKenmochi、Michihiro Maruyama、Naotake Akutsu、KazunoriOhtsuki、Chikara Iwashita、Matsumoto Ikuko、Takehide Asano
    • Organizer
      12th Congress of the Asian
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2017-10-13  

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