Trial of determining prognostic factors in breast cancer patients

• Project/Area Number: 21591660
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: University of Toyama
• Principal Investigator: NAGATA Takuya 富山大学, 大学病院, 講師 (40303242)
• Co-Investigator(Kenkyū-buntansha): TSUKADA Kazuhiro 富山大学, 大学院・医学薬学研究部(医学), 教授 (90171967) ; 嶋田 裕 富山大学, 大学院・医学薬学研究部(医学), 准教授 (30216072)
• Co-Investigator(Renkei-kenkyūsha): SHIMADA Yutaka 富山大学, 大学院・医学薬学研究部(医学), 准教授 (30216072)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 乳腺外科学 / iPS細胞 / Nanog / KLF4 / 乳癌細胞 / iPS誘導因子 / 細胞培養 / フローサイトメトリー

Research Abstract

The aim of present study, is to examine the relationship between the expression of iPS cell inducing factors(Oct4、Sox2、Klf-4、c-Myc、Nanog) and the prognosis of the breast cancer patients. Strong expression of NANOG was an indicator of a poor prognosis for breast cancer patients, while KLF4 was a favorable prognostic indicator.

Research Products

• [Journal Article] Prognostic significance of NANOG and KLF4 in breast carcinoma patients (2012)
  • Author(s): Nagata T, Shimada Y, Sekine S, Osawa S, Hori R, Matsui K, Okumura T, Fukuoka J, Tsukada K
  • Journal Title: Breast Cancer 2012 Volume: 21 Issue: 1 Pages: 96-101
  • DOI: 10.1007/s12282-012-0357-y
  • Peer Reviewed
• [Journal Article] MicroRNA profiling of gastric cancer patients from formalin-fixed paraffin-embedded sample (2011)
  • Author(s): Osawa S, Shimada Y, Nagata T, Tsukada K
  • Journal Title: ONCOLOGY LETTERS Volume: 2 Pages: 613-619
  • Peer Reviewed
• [Journal Article] Usefulness of blood suppy visualization by indocyanine green fluorescence for reconstruction during esophagectomy (2011)
  • Author(s): Shimada Y, Nagata T, Tsukada K.
  • Journal Title: Esophagus Volume: 8 Pages: 259-266
  • Peer Reviewed
• [Journal Article] 肝・胆道系症候群(第2版)-その他の肝・胆道系疾患を含めて-III肝外胆道編II胆嚢その他陶器様胆嚢 (2011)
  • Author(s): 長田拓哉、魚谷英之、塚田一博
  • Journal Title: 別冊日本臨牀新領域別症候群シリーズ Volume: 15 Pages: 477-479
• [Journal Article] 肝臓・門脈・脾臓1. Budd-Chiari症候群、外科 (2011)
  • Author(s): 塚田一博、松井恒志、長田拓哉
  • Journal Title: 特集外科医が知っておくべき徴候と症候群V Volume: 73 Pages: 1358-1360
• [Journal Article] リンパ節郭清を伴う胆嚢摘出術1胆嚢癌に対する全層・単純胆嚢摘出術とリンパ節郭清、手術 (2011)
  • Author(s): 塚田一博、長田拓哉、澤田成朗
  • Journal Title: 特集:ステージに応じた胆嚢癌手術I Volume: 65 Pages: 1853-1857
• [Journal Article] 門脈圧亢進症・脾機能亢進症 (2011)
  • Author(s): 松井恒志、長田拓哉、塚田一博
  • Journal Title: 消化器外科学レビュー Pages: 113-118
• [Journal Article] Increase in ouabain-sensitive K+-ATPase activity in hepatocelluar carcinoma by overexpression of Na+, K+-ATPaseα3-isoform (2010)
  • Author(s): Shibuya K, Fukuoka J, Tsukada K.
  • Journal Title: European Journal of Pharmacology Volume: 638 Pages: 42-46
  • Peer Reviewed
• [Journal Article] Tumor necrosis factor-αaccelerates apoptosis of steatotic hepatocytes from a murine model of non-alcoholic fatty liver disease (2010)
  • Author(s): Wei Zhang, Tsukada K, Naihong Chen
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 391 Pages: 1731-1736
  • Peer Reviewed
• [Journal Article] Effect of small interfering RNAs targeting fascin on human esophageal squamous cell carcinoma cell lines (2010)
  • Author(s): Ortiz C. Ito T., Shimada Y.
  • Journal Title: Diagnostic Pathology Pages: 41-50
  • Peer Reviewed
• [Journal Article] Frequent silencing of protocadherin 17, a candidate tumour suppressor for esophageal squamous cell carcinoma (2010)
  • Author(s): Haruki S, Shimada Y., Kawano T.
  • Journal Title: Carcinogenesis Pages: 1027-1036
  • Peer Reviewed
• [Journal Article] 食道癌に対する集学的治療の効果予測と個別化治療 (2010)
  • Author(s): 長田拓哉, 嶋田裕, 塚田一博
  • Journal Title: 消化器外科 Volume: 33 Pages: 1339-1345
• [Journal Article] 門脈と脾臓のUp date I門脈6.食道・胃静脈瘤に対する外科治療の役割 (2010)
  • Author(s): 奥村知之、塚田一博, 長田拓哉
  • Journal Title: 外科 Volume: 72 Pages: 32-35
• [Journal Article] Anastrozoleが著効した高齢者乳癌の1例 (2010)
  • Author(s): 松井恒志、長田拓哉, 嶋田裕, 塚田一博
  • Journal Title: 癌と化学療法 Volume: 37 Pages: 1557-1560
  • Peer Reviewed
• [Journal Article] 門脈域分水嶺からみた門脈圧亢進症の治療のあり方 (2010)
  • Author(s): 塚田一博
  • Journal Title: 日門亢会誌 Volume: 16 Pages: 176-179
  • NAID: 130003378798
  • Peer Reviewed
• [Journal Article] 外科臨床に必要な漢方の基礎知識.肝胆膵疾患に対する漢方治療 (2010)
  • Author(s): 澤田成朗、長田拓哉, 塚田一博
  • Journal Title: 外科治療 Volume: 103 Pages: 559-563
  • Peer Reviewed
• [Journal Article] Involvement of aquaporin-5 in differentiation of human gastric cancer cells (2009)
  • Author(s): Watanabe T, Tsukada K, Sakai H
  • Journal Title: J Physiol Sci Volume: 59 Pages: 113-122
  • NAID: 10025218436
  • Peer Reviewed
• [Journal Article] cDNA microarray analysis of esophageal cancer : discoveries and prospects (2009)
  • Author(s): Shimada Y, Sato F, Shimizu K, Tsujimoto G, Tsukada K.
  • Journal Title: Gen Thorac Cardiovasc Surg Volume: 57 Pages: 347-356
  • NAID: 10025151661
  • Peer Reviewed
• [Journal Article] 消化器癌の診断・治療胆嚢癌診断と外科治療の選択 (2009)
  • Author(s): 塚田一博、嶋田裕, 長田拓哉
  • Journal Title: 消化器外科 Volume: 32 Pages: 869-873
• [Journal Article] 食道癌術後再建結腸癌の1切除例
  • Author(s): 大村哲也、嶋田裕, 塚田一博
  • Journal Title: 手術 Volume: 64 Pages: 1999-2002
  • Peer Reviewed
• [Presentation] The influence of iPS-inducing factors patients with breast cancer (2011)
  • Author(s): Takuya Nagata
  • Organizer: ASCO breast
  • Place of Presentation: San Fran Cisco
  • Year and Date: 2011-09-05
• [Presentation] Preliminary results of prone-position esophagectomy (2011)
  • Author(s): Shimada Y
  • Organizer: International Surgical Week/ISW2011
  • Place of Presentation: 横浜
• [Presentation] Case of peptic ulcer in the gastric tube substituted for esophagus after esopfagectomy (2011)
  • Author(s): Shimada Y
  • Organizer: International Surgical Week/ISW2011
  • Place of Presentation: 横浜
• [Presentation] Prediction of chemosensitivity of gastric cancer patients by micro-RAN profilig using formalin-fixed paraffin embedded(FFPE) specimens (2011)
  • Author(s): Shimada Y
  • Organizer: 9th International Gastric Cancer Congress
  • Place of Presentation: ソウル
• [Presentation] MicroRNA profiling of esophageal squamous cell carcinoma pa from formalin-fixed paraffin-embedded(FFPE) specimens (2011)
  • Author(s): Shimada Y
  • Organizer: AACR 102nd ANNUAL MEETING
  • Place of Presentation: オーランド
• [Presentation] MicroRNA profiling of esophageal squamous cell cancer and gastric cancer from formalin-fixed paraffin embedded(FFPE) specimens (2011)
  • Author(s): Shimada Y
  • Organizer: 13th World congress on gastrointestinal cancer
  • Place of Presentation: バルセロナ
• [Presentation] The influence of iPS-inducing factors NANOG and KLF4 in the prognosis of patients with breast cancer (2011)
  • Author(s): Nagata T
  • Organizer: 2011 Breast Cancer Symposium
  • Place of Presentation: サンフランシスコ
• [Presentation] A trial of nutritional support after breast cancer operation (2011)
  • Author(s): Nagata T.
  • Organizer: 16th Reach to Recovery International Breast Cancer Support Conference
  • Place of Presentation: 台北
• [Presentation] 乳癌におけるHR, HER2発現とiPS細胞誘導因子の検討 (2011)
  • Author(s): 長田拓哉
  • Organizer: 第111回日本外科学会定期学術集会
  • Place of Presentation: 紙上開催
• [Presentation] 門脈圧亢進症患者における脾摘後免疫担当細胞の動態について (2011)
  • Author(s): 長田拓哉
  • Organizer: 第66回日本消化器外科学会総
  • Place of Presentation: 名古屋
• [Presentation] 乳癌におけるiPS細胞誘導因子の解析 (2011)
  • Author(s): 長田拓哉
  • Organizer: 第32回癌免疫外科研究
  • Place of Presentation: 和歌山
• [Presentation] 乳癌細胞におけるiPS誘導因子の関与 (2011)
  • Author(s): 長田拓哉
  • Organizer: 第19回日本乳癌学会学術総会
  • Place of Presentation: 仙台
• [Presentation] 門脈圧亢進症患者における脾臓の検討 (2011)
  • Author(s): 長田拓哉
  • Organizer: 第18回日本門脈圧亢進症学会総会
  • Place of Presentation: 福岡
• [Presentation] 乳癌症例におけるiPS細胞誘導因子発現の検討 (2010)
  • Author(s): 長田拓哉
  • Organizer: 日本乳癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2010-06-24
• [Presentation] MicroRNA profiling of gastric cancer petients from formalin-fixed paraffin-embedded(FFPE) samples (2010)
  • Author(s): Shimada Y.
  • Organizer: 101st annual meeting of AACR
  • Place of Presentation: Washington
• [Presentation] Predicting sensitivity for preoperative 5-Fu plus cisplatin regimen by DNA microarray analysis of preoperative endoscopic biopsy specimens from esophageal cancer patients (2010)
  • Author(s): Shimada Y
  • Organizer: 12th world congress of the diseases of the esophagus
  • Place of Presentation: Kagoshima
• [Presentation] Analysis of iPS inductive gene expression by esophageal cancer tisse array (2010)
  • Author(s): Shimada Y.
  • Organizer: 12th world congress of the diseases of the esophagus
  • Place of Presentation: Kagoshima
• [Presentation] Usefulness of the blood supply visualization in gastric tube during esophagectomy by indocyanin green fluorescence (2010)
  • Author(s): Shimada Y.
  • Organizer: 12th world congress of the diseases of the esophagus
  • Place of Presentation: Kagoshima
• [Presentation] Usefulness of the blood supply visuarization in reconstructive organ during esophagectomy by indocyanin green fluorescence (2010)
  • Author(s): Shimada Y.
  • Organizer: 96th Annual Meeting of American College of Surgeons
  • Place of Presentation: Washington DC
• [Presentation] 乳癌細胞におけるホルモンレセプター、HER2発現とiPS細胞誘導因子の検討 (2010)
  • Author(s): 長田拓哉
  • Organizer: 第18回日乳癌学会学術総会
  • Place of Presentation: 札幌市
• [Presentation] 門脈圧亢進症患者における脾摘後の血液中リンパ球の動態 (2010)
  • Author(s): 長田拓哉
  • Organizer: 第65回日本消化器外科学会総会
  • Place of Presentation: 下関市
• [Presentation] 鏡視下乳房温存手術において術後温存乳房の整容性をさらに高める工夫 (2010)
  • Author(s): 長田拓哉
  • Organizer: 第23回日本内視鏡外科学会総会
  • Place of Presentation: 横浜
• [Presentation] Visualization of blood supply in gastric tube during esophagectomy by indocyanin green fluorescence (2009)
  • Author(s): Shimada Y.
  • Organizer: The 43rd World Congress of International Society of Surgery
  • Place of Presentation: アデレード
• [Presentation] Successful resection of primary cancer in a colonic interposition graft after esophagectomy for esophageal cancer : a case report (2009)
  • Author(s): Shimada Y.
  • Organizer: The 43rd World Congress of International Society of Surgery
  • Place of Presentation: アデレード
• [Presentation] 乳癌術後栄養管理における当科の試み (2009)
  • Author(s): 長田拓哉
  • Organizer: 第24回日本静脈経腸栄養学会
  • Place of Presentation: 鹿児島
• [Presentation] 乳輪周囲非切開手技による鏡視下乳房温存手術 (2009)
  • Author(s): 長田拓哉
  • Organizer: 第109回日本外科学会定期学術集会
  • Place of Presentation: 福岡
• [Presentation] 非浸潤性乳管癌(DCIS)における切除断端腸性症例の検討 (2009)
  • Author(s): 長田拓哉
  • Organizer: 第17回日本乳癌学会学術総会
  • Place of Presentation: 東京
• [Presentation] 門脈圧亢進症患者における脾摘後の血液中リンパ球の動態について (2009)
  • Author(s): 長田拓哉
  • Organizer: 第16回日本門脈圧亢進症学会総会
  • Place of Presentation: 郡山
• [Presentation] 鏡視下頸部手術の検討 (2009)
  • Author(s): 長田拓哉
  • Organizer: 第42回日本甲状腺外科学会学術集会
  • Place of Presentation: 名古屋
• [Presentation] 鏡視下乳房温存切除術の適応について (2009)
  • Author(s): 長田拓哉
  • Organizer: 第71回日本臨床外科学会総会
  • Place of Presentation: 京都
• [Book] 胆嚢癌:胆嚢床切除～S4a・S5,胆管切除、胆・膵外科手術 (2011)
  • Author(s): 塚田一博、奥村知之、吉岡伊作
  • Publisher: 標準手術からのステップアップ
• [Book] 食道癌個別化治療に向けた高感度DNAチップの開発と応用 (2010)
  • Author(s): 嶋田裕、長田拓哉,塚田一博
  • Publisher: 分子細胞治療フロンティア2010
• [Book] 門脈圧亢進症・脾機能亢進症 (2010)
  • Author(s): 松井恒志,塚田一博
  • Publisher: 消化器外科学レビュー2010
• [Remarks]
  • URL: http://www.med.u-toyama.ac.jp/surg2/index.html