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Development of treatment for papillary and anaplastic thyroid carcinoma by targeting cancer-specific aberrant protein

Research Project

Project/Area Number 21591663
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionNagoya University

Principal Investigator

KIKUMORI Toyone  名古屋大学, 医学部附属病院, 助教 (90402635)

Co-Investigator(Kenkyū-buntansha) HAYASHI Yoshitaka  名古屋大学, 環境医学研究所, 准教授 (80420363)
KOBAYASHI Takeshi  中部大学, 生物機能開発研究所, 客員教授 (10043324)
NAKAO Akimasa  名古屋大学, 大学院・医学系研究科, 教授 (70164754)
中尾 昭公  名古屋大学, 医学系研究科, 教授 (70167542)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsBRAF / 甲状腺癌 / 温熱治療 / ヒートショック蛋白
Research Abstract

Suppression of BRAF expression in human anaplastic thyroid carcinoma cell line NPA, human papillary thyroid carcinoma cell line K1 those have BRAF mutation which is involved in malignant transformation and papillary thyroid carcinoma cell line TPC1 without BRAF mutation reduced expression of genes related to malignant transformation. In clinical thyroid carcinoma specimen, approximately 90% of cases have mutation in BRAF activating mutation. HSP90 inhibitor which is anticipated to reduce BRAF expression inhibits cell proliferation in other cancer cell lines.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (13 results)

All 2012 2011 2010 2009

All Journal Article (7 results) (of which Peer Reviewed: 5 results) Presentation (6 results)

  • [Journal Article] Aberrant promoterme thy lation in overexpression ofCITED1 in papillary thyroid cancer2011

    • Author(s)
      Sassa M, Hayashi Y, Watanabe R, Kikumori T, Imai T, Kurebayashi J, Kiuchi T, Murata Y.
    • Journal Title

      Thyroid

      Volume: 21巻 Pages: 511-517

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 【甲状腺外科の進歩】甲状腺未分化癌の治療の実際2011

    • Author(s)
      菊森豊根、今井常夫
    • Journal Title

      外科治療

      Volume: 105巻 Pages: 353-358

    • Related Report
      2011 Final Research Report
  • [Journal Article] Aberrant promoter methylation in overexpression of CITED1 in papillary thyroid cancer2011

    • Author(s)
      Sassa, M., et al
    • Journal Title

      Thyroid

      Volume: 21 Issue: 5 Pages: 511-517

    • DOI

      10.1089/thy.2010.0295

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【甲状腺外科の進歩】甲状腺未分化癌の治療の実際2011

    • Author(s)
      菊森豊根, 他
    • Journal Title

      外科治療

      Volume: 105 Pages: 353-358

    • Related Report
      2011 Annual Research Report
  • [Journal Article] Aberrant promoter methylation in overexpression of CITED1 in papillary thyroid cancer2011

    • Author(s)
      Sassa, M., et. al.
    • Journal Title

      Thyroid

      Volume: 印刷中

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of BRAFV600E inaltered gene expression in papillary thyroid cancer2009

    • Author(s)
      Watanabe R, Hayashi Y, Sassa M, Kikumori T, Imai T, Kiuchi T, Murata Y.
    • Journal Title

      Endocr J

      Volume: 56巻 Pages: 407-14

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible involvement of BRAFV600E in altered gene expression in papillary thyroid cancer.2009

    • Author(s)
      Watanabe R, 他6名
    • Journal Title

      Endocr J. 56

      Pages: 407-414

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 陽性荷電マグネトリポソームと交番磁場による皮下再発腫瘍を対象とした温熱免疫療法2012

    • Author(s)
      菊森豊根
    • Organizer
      第18回日本乳癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-06-25
    • Related Report
      2011 Final Research Report
  • [Presentation] ヒト乳癌細胞株におけるHeat shock protein 90阻害剤による温熱効果増強アポトーシスの関連について2011

    • Author(s)
      菊森豊根
    • Organizer
      第17回日本乳癌学会総
    • Place of Presentation
      東京
    • Year and Date
      2011-07-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 陽性荷電マグネトリポソームと交番磁場による皮下再発甲状腺癌を対象とした温熱免疫療法2011

    • Author(s)
      菊森豊根
    • Organizer
      第111回日本外科学会定期学術総会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-26
    • Related Report
      2011 Final Research Report
  • [Presentation] 陽性荷電マグネトリポソームと交番磁場による皮下再発甲状腺癌を対象とした温熱免疫療法2011

    • Author(s)
      菊森豊根, 他7名
    • Organizer
      第111回日本外科学会定期学術総会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2011-05-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 陽性荷電マグネトリポソームと交番磁場による皮下再発腫瘍を対象とした温熱免疫療法2010

    • Author(s)
      菊森豊根, 他9名
    • Organizer
      第18回日本乳癌学会学術総会
    • Place of Presentation
      ロイトン札幌・札幌芸術文化の館
    • Year and Date
      2010-06-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒト乳癌細胞株におけるHeat shock protein 90阻害剤による温熱効果増強 アポトーシスの関連について2009

    • Author(s)
      菊森豊根, 他8名
    • Organizer
      第17回日本乳癌学会総会
    • Place of Presentation
      ホテル日航東京
    • Year and Date
      2009-07-04
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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