Development of treatment for papillary and anaplastic thyroid carcinoma by targeting cancer-specific aberrant protein

• Project/Area Number: 21591663
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Nagoya University
• Principal Investigator: KIKUMORI Toyone 名古屋大学, 医学部附属病院, 助教 (90402635)
• Co-Investigator(Kenkyū-buntansha): HAYASHI Yoshitaka 名古屋大学, 環境医学研究所, 准教授 (80420363) ; KOBAYASHI Takeshi 中部大学, 生物機能開発研究所, 客員教授 (10043324) ; NAKAO Akimasa 名古屋大学, 大学院・医学系研究科, 教授 (70164754) ; 中尾 昭公 名古屋大学, 医学系研究科, 教授 (70167542)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: BRAF / 甲状腺癌 / 温熱治療 / ヒートショック蛋白

Research Abstract

Suppression of BRAF expression in human anaplastic thyroid carcinoma cell line NPA, human papillary thyroid carcinoma cell line K1 those have BRAF mutation which is involved in malignant transformation and papillary thyroid carcinoma cell line TPC1 without BRAF mutation reduced expression of genes related to malignant transformation. In clinical thyroid carcinoma specimen, approximately 90% of cases have mutation in BRAF activating mutation. HSP90 inhibitor which is anticipated to reduce BRAF expression inhibits cell proliferation in other cancer cell lines.

Research Products

• [Journal Article] Aberrant promoterme thy lation in overexpression ofCITED1 in papillary thyroid cancer (2011)
  • Author(s): Sassa M, Hayashi Y, Watanabe R, Kikumori T, Imai T, Kurebayashi J, Kiuchi T, Murata Y.
  • Journal Title: Thyroid Volume: 21巻 Pages: 511-517
  • Peer Reviewed
• [Journal Article] 【甲状腺外科の進歩】甲状腺未分化癌の治療の実際 (2011)
  • Author(s): 菊森豊根、今井常夫
  • Journal Title: 外科治療 Volume: 105巻 Pages: 353-358
• [Journal Article] Aberrant promoter methylation in overexpression of CITED1 in papillary thyroid cancer (2011)
  • Author(s): Sassa, M., et al
  • Journal Title: Thyroid Volume: 21 Issue: 5 Pages: 511-517
  • DOI: 10.1089/thy.2010.0295
  • Peer Reviewed
• [Journal Article] 【甲状腺外科の進歩】甲状腺未分化癌の治療の実際 (2011)
  • Author(s): 菊森豊根, 他
  • Journal Title: 外科治療 Volume: 105 Pages: 353-358
• [Journal Article] Aberrant promoter methylation in overexpression of CITED1 in papillary thyroid cancer (2011)
  • Author(s): Sassa, M., et. al.
  • Journal Title: Thyroid Volume: 印刷中
  • Peer Reviewed
• [Journal Article] Possible involvement of BRAFV600E inaltered gene expression in papillary thyroid cancer (2009)
  • Author(s): Watanabe R, Hayashi Y, Sassa M, Kikumori T, Imai T, Kiuchi T, Murata Y.
  • Journal Title: Endocr J Volume: 56巻 Pages: 407-14
  • Peer Reviewed
• [Journal Article] Possible involvement of BRAFV600E in altered gene expression in papillary thyroid cancer. (2009)
  • Author(s): Watanabe R, 他6名
  • Journal Title: Endocr J. 56 Pages: 407-414
  • Peer Reviewed
• [Presentation] 陽性荷電マグネトリポソームと交番磁場による皮下再発腫瘍を対象とした温熱免疫療法 (2012)
  • Author(s): 菊森豊根
  • Organizer: 第18回日本乳癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-06-25
• [Presentation] ヒト乳癌細胞株におけるHeat shock protein 90阻害剤による温熱効果増強アポトーシスの関連について (2011)
  • Author(s): 菊森豊根
  • Organizer: 第17回日本乳癌学会総
  • Place of Presentation: 東京
  • Year and Date: 2011-07-04
• [Presentation] 陽性荷電マグネトリポソームと交番磁場による皮下再発甲状腺癌を対象とした温熱免疫療法 (2011)
  • Author(s): 菊森豊根
  • Organizer: 第111回日本外科学会定期学術総会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-26
• [Presentation] 陽性荷電マグネトリポソームと交番磁場による皮下再発甲状腺癌を対象とした温熱免疫療法 (2011)
  • Author(s): 菊森豊根, 他7名
  • Organizer: 第111回日本外科学会定期学術総会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2011-05-26
• [Presentation] 陽性荷電マグネトリポソームと交番磁場による皮下再発腫瘍を対象とした温熱免疫療法 (2010)
  • Author(s): 菊森豊根, 他9名
  • Organizer: 第18回日本乳癌学会学術総会
  • Place of Presentation: ロイトン札幌・札幌芸術文化の館
  • Year and Date: 2010-06-25
• [Presentation] ヒト乳癌細胞株におけるHeat shock protein 90阻害剤による温熱効果増強 アポトーシスの関連について (2009)
  • Author(s): 菊森豊根, 他8名
  • Organizer: 第17回日本乳癌学会総会
  • Place of Presentation: ホテル日航東京
  • Year and Date: 2009-07-04