Development of a novel cellular vaccine of GITRL-Fc expressing tumor cells for treatment of patients with advanced malignancy

• Project/Area Number: 21591664
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Mie University
• Principal Investigator: IKEDA Hiroaki 三重大学, 大学院・医学系研究科, 准教授 (40374673)
• Co-Investigator(Kenkyū-buntansha): NISHIKAWA Hiroyoshi 大阪大学, 免疫学フロンティア研究センター, 准教授 (10444431)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: GITRL / GITRL-Fc / 抗腫瘍免疫 / T細胞マルチファンクション性 / 制御性T細胞 / T細胞移入療法 / 遺伝子療法 / siT+ AV3CRベクター / siTCRベクター

Research Abstract

Tumor cell vaccine expressing GITRL-Fc and gene therapy with adenovirus encoding GITRL-Fc were found to be effective in cancer immunotherapy. We started a clinical trial with TCR-gene modified T cells that express MAGE-A4-specific TCR for patients with advanced esophageal cancer. Stimulation through integrin molecules and CD4 T cell-help were found to enhance multifunctionality and survival of tumor specific CD8+ T cells.

Research Products

• [Journal Article] T-cell receptor gene therapy targeting melanoma-associated antigen-A4 inhibits human tumor growth in non-obese diabetic/SCID/gc_null mice (2012)
  • Author(s): Shirakura Y Mizuno Y, Wang L, Imai N, Amaike C, Sato E, Ito M, Nukaya I, Mineno J, Takesako K, Ikeda H, Shiku H
  • Journal Title: Cancer Sci Volume: 103(1) Pages: 17-25
  • Peer Reviewed
• [Journal Article] Intracellular tumor-associated antigens represent effective targets for passive immunotherapy (2012)
  • Author(s): Noguchi T, Kato T, Wang L, Maeda Y, Ikeda H, Sato E, Knuth A, Gnjatic S, Ritter G, Sakaguchi S, Old LJ, Shiku H, Nishikawa H
  • Journal Title: Cancer Res Volume: 72(7) Pages: 1672-1682
  • Peer Reviewed
• [Journal Article] Intracellular tumor-associated antigens represent effective targets for passive immunotherapy (2012)
  • Author(s): Noguchi T, Kato T, Wang L, Maeda Y, Ikeda H, Sato E, Knuth A, Gnjatic S, Ritter G, Sakaguchi S, Old LJ, Shiku H, Nishikawa H
  • Journal Title: Cancer Research Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] T-cell receptor gene therapy targeting melanoma-associated antigen-A4 inhibits human tumor growth in non-obese diabetic/SCID/γc^<null> mice (2012)
  • Author(s): Shirakura Y, Mizuno Y, Wang L, Imai N, Amaike C, Sato E, Ito M, Nukaya I, Mineno J, Takesako K, Ikeda H, Shiku H
  • Journal Title: Cancer Science Volume: 103 Issue: 1 Pages: 17-25
  • DOI: 10.1111/j.1349-7006.2011.02111.x
  • Peer Reviewed
• [Journal Article] siRNA-mediated silencing of PD-1 ligands enhances tumor-specific human T-cell effector functions (2011)
  • Author(s): Iwamura, K., T.Kato, Y.Miyahara, H.Naota, J.Mineno, H.Ikeda, H.Shiku
  • Journal Title: Gene Therapy Volume: (印刷中) Issue: 10 Pages: 959-966
  • DOI: 10.1038/gt.2011.185
  • Peer Reviewed
• [Journal Article] Association of CD8^+ T cell infiltration in esophageal carcinomalesions with HLA class I antigen expression and survival (2011)
  • Author(s): Tsuchikawa, T, Ikeda H, Cho Y, Miyamoto M, Shichinohe, T, Hirano S, Kondo S
  • Journal Title: Clin Exp Immunol Volume: 164(1) Pages: 50-6
  • Peer Reviewed
• [Journal Article] Association of CD8+ T cell infiltration in esophageal carcinomalesions with HLA class I antigen expression and survival (2011)
  • Author(s): Tsuchikawa T, Ikeda H, Cho Y, Miyamoto M, Shichinohe T, Hirano S, Kondo S.
  • Journal Title: Clinical And Experimental Immunology Volume: 164 Pages: 50-56
  • Peer Reviewed
• [Journal Article] Improved expression and reactivity of transduced tumor-specific TCRs in human lymphocytes by silencing of endogenous TCR (2009)
  • Author(s): Okamoto S, Mineno J, Ikeda H, Fujiwara H, Yasukawa M, Shiku H, Kato I
  • Journal Title: Cancer Res Volume: 69(23) Pages: 9003-11
  • Peer Reviewed
• [Journal Article] Antibody responses against NY-ESO-1 and HER2 antigens in patients vaccinated with combinations of cholesteryl pullulan(CHP)-NY-ESO-1 and CHP-HER2 with OK-432 (2009)
  • Author(s): Aoki M, Ueda S, Nishikawa H, Kitano S, Hirayama M, Ikeda H, Toyoda H, Tanaka K, Kanai M, Takabayashi A, Imai H, Shiraishi T, Sato E, Wada H, Nakayama E, Takei Y, Katayama N, Shiku H, Kageyama S
  • Journal Title: Vaccine Volume: 7(49) Pages: 6854-61
  • Peer Reviewed
• [Journal Article] GITR stimulation enhances multifunctionality of adoptively transferred tumor antigen-specific CD8^+ T cells with tumor regression (2009)
  • Author(s): Imai N, Ikeda H, Tawara I, Wang L, Wang L, Nishikawa H, Kato T, Shiku H
  • Journal Title: Cancer Sci Volume: 100(7) Pages: 1317-1325
  • Peer Reviewed
• [Journal Article] Improved expression and reactivity of transduced tumor-specific TCRs in human lymphocytes by silencing of endogenous TCR (2009)
  • Author(s): Okamoto S, Mineno J, Ikeda H, Fujiwara H, Yasukawa M, Shiku H, Kato I.
  • Journal Title: Cancer Research 69 Pages: 9003-9011
  • Peer Reviewed
• [Journal Article] Antibody responses against NY-ESO-1 and HER2 antigens in patients vaccinated with combinations of cholesteryl pullulan (CHP)-NY-ESO-1 and CHP-HER2 with OK-432 (2009)
  • Author(s): Aoki M, Ueda S, Nishikawa H, Kitano S, Hirayama M, Ikeda H, Toyoda H, Tanaka K, Kanai M, Takabayashi A, Imai H, Shiraishi T, Sato E, Wada H, Nakayama E, Takei Y, Katayama N, Shiku H, Kageyama S
  • Journal Title: Vaccine 27 Pages: 6854-6861
  • Peer Reviewed
• [Journal Article] GITR stimulation enhances multifunctionality of adoptively transferred tumor antigen-specific CD8^+ T cells with tumor regression (2009)
  • Author(s): Imai N, Ikeda H, Tawara I, Wang L, Wang L, Nishikawa H, Kato T, Shiku H
  • Journal Title: Cancer Science 100 Pages: 1317-1325
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): 池田裕明, 珠玖洋
  • Journal Title: 内科学書 改訂第7版(中山書店) Pages: 34-42
• [Journal Article] (2009)
  • Author(s): 池田裕明, 珠玖洋
  • Journal Title: 実験医学 2009年9月号 Vol. 27, No. 14(羊土社) Pages: 2176-2184
• [Journal Article] (2009)
  • Author(s): 池田裕明
  • Journal Title: 最新医学 2009年11月号 Vol. 64, No. 11(最新医学社) Pages: 86-93
• [Presentation] T細胞のマルチファンクション性はその生存性と輸注療法の効果を規定する (2011)
  • Author(s): 今井奈緒子、池田裕明、細井勇人、俵功、山根真妃子、王立楠、森和子、日向千咲、珠玖洋
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-28
• [Presentation] インテグリンシグナルを介した教育による効果的なT細胞療法の確立 (2011)
  • Author(s): 細井勇人、池田裕明、日向千咲、王立楠、織戸由貴、今井奈緒子、糠谷育衛、榎竜嗣、峰野純一、竹迫一任、近藤哲、珠玖洋
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-28
• [Presentation] The importance of IgG subclass and IgE response in CHP-MAGE-A4 cancer vaccination (2011)
  • Author(s): Noriaki Kyogoku, Takahiro Tsuchikawa, Masaki Miyamoto, Takeiro Abiko, Aki Kuroda, Takehiro Maki, Yoshiyuki Yamamura, Satoshi Hirano, Satoshi Kondo, Hiroaki Ikeda, Shinichi Kageyama, Hiroshi Shiku
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-05
• [Presentation] Multifunctionality determines T cell survival fate (2011)
  • Author(s): Naoko Imai, Hiroaki Ikeda, Isao Tawara, Hayato Hosoi, Kazuko Mori, Chisato Hyuga, Makiko Yamane, Linan Wang, Hiroshi Shiku
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-05
• [Presentation] siRNA-mediated silencing of PD-1 ligands of tumor-specific human T cells enhances T cell function (2011)
  • Author(s): Koichi Iwamura, Takuma Katoh, Yoshihiro Miyahara, Hiroaki Naota, Junichi Mineno, Hiroaki Ikeda, Kazutoh Takesako, Hiroshi Shiku
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-05
• [Presentation] Nucleic MAGE-A4 promotes apoptosis in p53-overexpressing cancer cells of non-small cell lung carcinoma (2011)
  • Author(s): Aki Kuroda, Masaki Miyamoto, Takehiro Abiko, Takahiro Tsuchikawa, Noriaki Kyogoku, Takehiro Maki, Yoshiyuki Yamamura, Yasuhiro Hida, Kichizo Kaga, Satoshi Hirano, Hiroaki Ikeda, Hiroshi Shiku, Satoshi Kondo
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-04
• [Presentation] Silencing of endogenous TCR improved the efficacy and safety in TCR gene therapy (2011)
  • Author(s): Sachiko Okamoto, Hiroaki Ikeda, Hiroshi Fujiwara, Ikuei Nukaya, Hirofumi Yoshioka, Kiyotaka Kuzushima, Masaki Yasukawa, Hiroshi Shiku, Junichi Mineno
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-04
• [Presentation] In vivo persistence of adoptively transferred TCR gene-modified lymp hocytes in patients with advanced esophageal cancer (2011)
  • Author(s): Shinichi Kageyama, Hiroaki Ikeda, Yoshihiro Miyahara, Sahoko Hori, Kanako Saito, Naoko Imai, Sachiko Okamoto, Daisuke Tomura, Ikuei Nukaya, Junichi Mineno, Kazutoh Takesako, Naoyuki Katayama, Hiroshi Shiku
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-04
• [Presentation] Signals through VLA-4 and -5 in CD8^+ T cell improve the efficacy of adoptive therapy of tumor (2011)
  • Author(s): Hayato Hosoi, Hiroaki Ikeda, Chisaki Hyuga, Linan Wang, Yuki Orito, Ikuei Nukaya, Tatsuji Enoki, Junichi Mineno, Kazuto Takesako, Satoshi Kondo' Hiroshi Shiku
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-04
• [Presentation] Gene-modified T cell therapy : Harnessing lymphocytes for effective cancer treatment (2011)
  • Author(s): Hiroaki Ikeda, Naoko Imai, Hayato Hosoi, Makiko Yamane, Sachiko Okamoto, Junichi Mineno, Kazutoh Takesako, Shinichi Kageyama, Hiroshi Shiku
  • Organizer: 第70回日本癌学会学術総会招待講演
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-03
• [Presentation] Gene-modified T cell therapy : Harnessing lymphocytes for effective cancer treatment (2011)
  • Author(s): Hiroaki Ikeda, Naoko Ima1, Hayato Hosoi, Makiko Yamane, Sachiko Okamoto, Junichi Mineno, Kazutoh Takesako, Shinichi Kageyama, Hiroshi Shiku
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋(招待講演)
  • Year and Date: 2011-10-03
• [Presentation] ANTIGEN RECEPTOR GENE-MODIFIED LYMPHOCYTES : HARNESSING T CELLS FOR EFFECTIVE CANCER TREATMENT (2011)
  • Author(s): Hiroaki Ikeda, Naoko Imai, Hayato Hosoi, Makiko Yamane, Sachiko Okamoto, Junichi Mineno, Shinichi Kageyama, Kazutoh Takesako, Hiroshi Shiku
  • Organizer: 第17回日本遺伝子治療学会2011年次学術集会招待講演
  • Place of Presentation: 福岡
• [Presentation] 遺伝子改変T細胞輸注療法 (2011)
  • Author(s): 池田裕明、今井奈緒子、細井勇人、山根真妃子、岡本幸子、峰野純一、竹迫一任、影山慎一、珠玖洋
  • Organizer: 第15回日本がん免疫学会総会招待講演
  • Place of Presentation: 大阪
• [Presentation] 遺伝子改変T細胞輸注療法 (2011)
  • Author(s): 池田裕明、今井奈緒子、細井勇人、山根真妃子、岡本幸子、峰野純一、竹迫一任、影山慎一、珠玖洋
  • Organizer: 第15回日本がん免疫学会総会
  • Place of Presentation: 大阪(招待講演)
• [Presentation] ANTIGEN RECEPTOR GENE-MODIFIED LYMPHOCYTES : HARNESSING T CELLS FOR EFFECTIVE CANCER TREATMENT (2011)
  • Author(s): Hiroaki Ikeda, Naoko Imai, Hayato Hosoi, Makiko Yamane, Sachiko Okamoto, Junichi Mineno, Shinichi Kageyama, Kazutoh Takesako, Hiroshi Shiku
  • Organizer: 第17回日本遺伝子治療学会
  • Place of Presentation: 福岡(招待講演)
• [Presentation] VLA-4、VLA-5シグナルはCTL輸注療法の抗腫瘍効果を向上する (2011)
  • Author(s): 細井勇人、池田裕明、日向千咲、王立楠、織戸由貴、糠谷育衛、榎竜嗣、峰野純一、竹迫一任、近藤哲、珠玖洋
  • Organizer: 第15回日本がん免疫学会総会
  • Place of Presentation: 大阪
• [Presentation] 内在性TCRのノックダウンによる高効率かつ安全性の高いTCR遺伝子治療法の開発 (2011)
  • Author(s): 岡本幸子、池田裕明、藤原弘、糠谷育英、吉岡広文、葛島清隆、安川正貴、珠玖洋、峰野純一
  • Organizer: 第15回日本がん免疫学会総会
  • Place of Presentation: 大阪
• [Presentation] ヒト腫瘍抗原特異的T細胞へのPD-L1/PD-L2 siRNA導入によるT細胞機能の増強 (2011)
  • Author(s): 岩村康一、加藤琢磨、宮原慶裕、直田浩明、峰野純一郎、岡本幸子、池田裕明、竹迫一任、珠玖洋
  • Organizer: 第15回日本がん免疫学会総会
  • Place of Presentation: 大阪
• [Presentation] Highly efficient and safe vectors for TCR gene therapy : Silencing of endogenous TCR improved expression and anti-tumor reactivity of transduced tumor-specific TCRs in human lymphocytes (2011)
  • Author(s): Sachiko Okamoto, Hiroaki Ikeda, Hiroshi Fujiwara, Ikuei Nukaya, Hirofumi Yoshioka, Masaki Yasukawa, Hiroshi Shiku, Junichi Mineno
  • Organizer: 14th Annual meeting of American Society of Gene & Cell Therapy
  • Place of Presentation: Seattle WA USA
• [Presentation] がん特異的T細胞輸注療法の新展開 (2010)
  • Author(s): 池田裕明、今井奈緒子、王立楠、細井勇人、岡本幸子、峰野純一、影山慎一、珠玖洋
  • Organizer: 第31回日本臨床薬理学会年会
  • Place of Presentation: 京都(招待講演)
  • Year and Date: 2010-12-03
• [Presentation] Gene-Modified Lymphocytes : Harnessing T Cells for Effective Cancer Treatment (2010)
  • Author(s): Ikeda H, Okamoto S, Mineno J, Imai N, Kageyama S, Ito M, Yasukawa M, Takesako K, Shiku H
  • Organizer: International Society for Cell Therapy, 1^<st> Asia-Pacific Regional Meeting
  • Place of Presentation: 宮崎(招待講演)
  • Year and Date: 2010-10-20
• [Presentation] Shiku H CD4^+ T cell help on the induction of functional tumor-specific CD8^+ T cells with survival marker (2010)
  • Author(s): Imai N, Ikeda H, Tawara I, Mori K, Yamane M, Wang L
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2010-08-23
• [Presentation] CD4^+ T cell help on the induction of functional tumor-specific CD8^+ T cells with survival marker (2010)
  • Author(s): Imai N, Ikeda H, Tawara I, Mori K, Yamane M, Wang L, Shiku H
  • Organizer: 14th International Congress of Immunology
  • Place of Presentation: 神戸
  • Year and Date: 2010-08-13
• [Presentation] CD4^+T細胞が腫瘍特異的CD8^+T細胞のマルチファンクション性・生存性・抗腫瘍活性に与える影響 (2010)
  • Author(s): 今井奈緒子、池田裕明、山根真妃子、王立楠、珠玖洋
  • Organizer: 第14回日本がん免疫学会学術集会
  • Place of Presentation: 熊本
  • Year and Date: 2010-07-22
• [Presentation] GENE-MODIFIED LYMPHOCYTES : A TRANSLATIONAL BRIDGE TO EFFECTIVE T CELL THERAPY OF CANCER (2010)
  • Author(s): Ikeda H, Okamoto S, Mineno J, Imai N, Kageyama S, Ito M, Yasukawa M, Takesako K, Shiku H
  • Organizer: 第16回日本遺伝子治療学会総会
  • Place of Presentation: 宇都宮(招待講演)
  • Year and Date: 2010-07-03
• [Presentation] CD8^+細胞傷害性T細胞の制御によるがん免疫療法 (2010)
  • Author(s): 池田裕明、今井奈緒子、岡本幸子、峰野純一、影山慎一、珠玖洋
  • Organizer: 第20回日本サイトメトリー学会学術集会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2010-06-27
• [Presentation] がん特異的T細胞輸注療法の新展開 (2010)
  • Author(s): 池田裕明、今井奈緒子、王立楠、細井勇人、岡本幸子、峰野純一、影山慎一、珠玖洋
  • Organizer: 第31回日本臨床薬理学会年会招待講演
  • Place of Presentation: 京都
• [Presentation] Gene-Modified Lymphocytes : Harnessing T Cells for Effective Cancer Treatment. International Society for Cell Therapy (2010)
  • Author(s): Ikeda H, Okamoto S, Mineno J, Imai N, Kageyama S, Ito M, Yasukawa M, Takesako K, Shiku H
  • Organizer: 1^<st> Asia-Pacific Regional Meeting,招待講演
  • Place of Presentation: Miyazaki, Japan
• [Presentation] Interaction with fibronectin fragment(RetroNectin) on TCR stimulation enhances proliferation and survival of human peripheral T cells (2010)
  • Author(s): Hosoi H, Ikeda H, Hyuga C, Orito Y, Nukaya I, Enoki R, Mineno J, Takesako K, Kondo S, Shiku H
  • Organizer: CRI symposium 2010
  • Place of Presentation: NY, USA
• [Presentation] A novel STAT3 inhibitor reverses tumor-associated immunosuppression and enhances the efficacy of adoptive T cell therapy of cancer (2010)
  • Author(s): Ikeda H, Sugiyama D, Muraoka D, Imai N, Harada N, Akiyama Y, Asai A, Shiku H
  • Organizer: International Society of Biological Therapy of Cancer, Annual Meeting 2010
  • Place of Presentation: Washington D. C., USA
• [Presentation] GENE-MODIFIED LYMPHOCYTES : A TRANSLATIONAL BRIDGE TO EFFECTIVE T CELL THERAPY OF CANCER (2010)
  • Author(s): Ikeda H, Okamoto S, Mineno J, Imai N, Kageyama S, Ito M, Yasukawa M, Takesako K, Shiku H
  • Organizer: 第16回日本遺伝子治療学会総会
  • Place of Presentation: 宇都宮
• [Presentation] CD8^+細胞傷害性T細胞の制御によるがん免疫療法 (2010)
  • Author(s): 池田裕明、今井奈緒子、岡本幸子、峰野純一、影山慎一、珠玖洋
  • Organizer: 第20回日本サイトメトリー学会学術集会
  • Place of Presentation: 東京
• [Presentation] A novel STAT3 inhibitor reverses tumor-associated immunosuppression and enhances the efficacy of adoptive T cell therapy of cancer (2010)
  • Author(s): Ikeda H, Sugiyama D, Muraoka D, Imai N, Harada N, Akiyama Y Asai A, Shiku H
  • Organizer: CRI symposium
  • Place of Presentation: 米国、ニューヨーク
• [Presentation] Interaction with fibronectin fragment (RetroNectin) on TCR stimulation enhances proliferation and survival of human peripheral T cells (2010)
  • Author(s): Hosoi H, Ikeda H, Hyuga C, Orito Y, Nukaya I, Enoki R, Mineno J, Takesako K, Kondo S, Shiku H
  • Organizer: CRI symposium
  • Place of Presentation: 米国、ニューヨーク
• [Presentation] The clinical response of novel CHP-MAGE-A4 cancer vaccine for the patients of gastro-intestinal malignancies refractory to the standard treatment. -the result of phase I clinical study (2010)
  • Author(s): Tsuchikawa T, Kyogoku N, Miyamoto M, Abiko T, Murota C, Kuroda A, Maki T, Yamamura Y, Hirano S, Kondo S, Ikeda H, Kageyama S, Shiku H
  • Organizer: CRI symposium
  • Place of Presentation: 米国、ニューヨーク
• [Presentation] Intra-tumor secretion of GITRL-Fc fusion protein induces and activates tumor-specific CD8^+ T cells resulting in tumor regression (2010)
  • Author(s): Ikeda H, Mitsui J, Ishihara M, Hosoi H, Mineno J, Kondo S, Shiku H
  • Organizer: 第16回日本遺伝子治療学会
  • Place of Presentation: 宇都宮
• [Presentation] THE NEXT GENERATION TCR GENE THERAPY : SILENCING OF ENDOGENOUS TCR IMPROVES THE EFFICACY OF TCR GENE THERAPY (2010)
  • Author(s): Okamoto S, Ikeda H, Fujiwara H, Yasukawa M, Shiku H, Mineno J
  • Organizer: 第16回日本遺伝子治療学会
  • Place of Presentation: 宇都宮
• [Presentation] CD4^+T細胞が腫瘍特異的CD8^+T細胞のマルチファンクション性・生存性・抗腫瘍活性に与える影響 (2010)
  • Author(s): Imai N, Ikeda H, Hosoi H, Yamane M, Wang L, Shiku H
  • Organizer: 第69回日本癌学会
  • Place of Presentation: 大阪
• [Presentation] The next generation TCR gene therapy for cancer (2010)
  • Author(s): Okamoto S, Ikeda H, Fujiwara H, Yasukawa M, Shiku H, Mineno J
  • Organizer: 第69回日本癌学会
  • Place of Presentation: 大阪
• [Presentation] Specific silencing of endogenous TCR with siRNAs in human lymphocytes improved expression and anti-tumor reactivity of transduced tumor-specific TCRs (2009)
  • Author(s): Okamoto S, Mineno J, Ikeda H, Fujiwara H, Yasukawa M, Shiku H, Kato I
  • Organizer: 24^<th> Annual Meeting of iSBTc
  • Place of Presentation: Washington, D. C., USA
• [Presentation] Adoptive immunotherapy for cancer with genetically engineered T cells「遺伝子改変T細胞移入療法」 (2009)
  • Author(s): Ikeda H, Okamoto S, Mineno J, Imai N, Ito M, Yasukawa M, Takesako K, Shiku H
  • Organizer: 第71回日本血液学会学術集会
  • Place of Presentation: 京都
• [Presentation] Multistage activation of tumor-specific CD8^+ T cells by intratumor secretion of GITRL-Fc「GITRL-Fc分泌型融合蛋白の腫瘍内発現による腫瘍特異的T細胞の多層的活性化機構」 (2009)
  • Author(s): Mitsui J, Ikeda H, Hosoi H, Mineno J, KatoI, Kondo S, Shiku H
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Presentation] CD^<4+> T cells play a critical role in the induction of multifunctionality of tumor-specific CD8^+ T cells resulting in effective tumor eradication (2009)
  • Author(s): Imai N, Ikeda H, Tawara I, Mori K, Yamane M, Wang L, Shiku H
  • Organizer: CRI symposium 2009
  • Place of Presentation: NY, USA
• [Presentation] Improved expression and anti-tumor reactivity of transduced tumor-specific TCRs in human lymphocytes by specific silencing of endogenous TCR (2009)
  • Author(s): Okamoto S, Mineno J, Ikeda H, Fujiwara H, Yasukawa M, Shiku H, Kato I
  • Organizer: CRI symposium 2009
  • Place of Presentation: NY, USA
• [Presentation] A critical role for the multifunctionality of anti-tumor human T cells in TCR gene therapy evaluated in an in vivo model utilizing NOG mice (2009)
  • Author(s): Mizuno Y, Ikeda H, Shirakura Y, Hiasa A, Hyuga C, Wang L, Imai N, Sato E, Ito M, Yu S, Mineno J, Kato I, Shiku H
  • Organizer: CRI symposium 2009
  • Place of Presentation: NY, USA
• [Presentation] GITRL-Fc分泌型融合蛋白の腫瘍内発現による腫瘍抗原特異的T細胞の活性化機構 (2009)
  • Author(s): 池田裕明、三井潤、峰野純一、加藤郁之進、珠玖洋
  • Organizer: 第13回日本がん免疫学会総会
  • Place of Presentation: 小倉
• [Presentation] Specific silencing of endogenous TCR with siRNAs in human lymphocytes improved expression and anti-tumor reactivity of transduced tumor-specific TCRs (2009)
  • Author(s): Okamoto S, Mineno J, Ikeda H, Fujiwara H, Yasukawa M, Shiku H, Kato I
  • Organizer: Internationaal Society for Biological Therapy of Cancer (iSBTc) 2009 annual meeting
  • Place of Presentation: 米国、ワシントンDC
• [Presentation] A critical role for the multifunctionality of anti-tumor human T cells in TCR gene therapy evaluated in an in vivo model utilizing NOG mice (2009)
  • Author(s): 水野優香理, 池田裕明, 白倉由隆, 日浅厚則, 日向千咲, 王立楠, 今井奈緒子, 佐藤永一, 伊藤守, 柳承信, 峰野純一, 加藤郁之進, 珠玖洋
  • Organizer: CRI symposium
  • Place of Presentation: 米国、ニューヨーク
• [Presentation] Improved expression and anti-tumor reactivity of transduced tumor-specific TCRs in human lymphocytes by specific silencing of endogenous TCR (2009)
  • Author(s): Okamoto S, Mineno J, Ikeda H, Fujiwara H, Yasukawa M, Shiku H, Kato I
  • Organizer: CRI symposium
  • Place of Presentation: 米国、ニューヨーク
• [Presentation] CD4^+ T cells play a critical role in the induction of multifunctionality of tumor-specific CD8^+ T cells resulting in effective tumor eradication (2009)
  • Author(s): Imai N, Ikeda H, Tawara I, Mori K, Yamane M, Wang L, Shiku H
  • Organizer: CRI symposium
  • Place of Presentation: 米国、ニューヨーク
• [Presentation] Silencing endogenous tcr α/β with sirnas and protecting transferred MAGE-A4-specific tcr α/β genes from siRNAs by codon modification enhance expression of transferred TCR α/β (2009)
  • Author(s): Mineno J, Okamoto S, Ikeda H, Shiku H, Kato I
  • Organizer: 第15回日本遺伝子治療学会総会
  • Place of Presentation: 大阪
• [Presentation] critical role for CD4^+ T cells in the induction of multifunctionality of tumor-specific CD8^+ T cells. 「CD4^+ T細胞は腫瘍特異的CD8^+ T細胞のマルチファンクション性獲得に重要な役割を果たす」 (2009)
  • Author(s): Imai N, Ikeda H, Tawara I, Mori K, Yamane M, Wang L, Shiku H
  • Organizer: 第39回日本免疫学会総会・学術集会
  • Place of Presentation: 大阪
• [Presentation] MAGE-A4特異的TCR遺伝子導入T細胞移入療法モデルにおけるヒトT細胞のマルチファンクション性誘導の検討 (2009)
  • Author(s): 水野優香理, 池田裕明, 白倉由隆, 日浅厚則, 日向千咲, 王立楠, 今井奈緒子, 佐藤永一, 伊藤守, 柳承信, 峰野純一, 加藤郁之進, 珠玖洋
  • Organizer: 第13回日本がん免疫学会総会
  • Place of Presentation: 小倉
• [Book] Immunotherapy (2012)
  • Author(s): Ikeda H
• [Book] ドラッグデリバリーシステムの新展開II (2012)
  • Author(s): 珠玖洋、原田直純、池田裕明
  • Publisher: シーエムシー出版
• [Book] Immunotherapeutic approaches (2011)
  • Author(s): Ikeda H, Shiku H
  • URL: http://www.landesbioscience.com/curie/
• [Book] がん生物学イラストレイテッド (2011)
  • Author(s): 今井奈緒子、池田裕明、珠玖洋
  • Publisher: 羊土社
• [Book] 日本臨床 (2011)
  • Author(s): 池田裕明、珠玖洋
• [Book] 臨床薬理 (2011)
  • Author(s): 池田裕明
• [Book] Glioma : Immunotherapeutic approaches (2011)
  • Author(s): Hiroaki Ikeda, Hiroshi Shiku
  • Publisher: Landes Bioscience and Springer Science+Business Media
• [Book] 日本臨床第69巻第9号 (2011)
  • Author(s): 池田裕明、珠玖洋
  • Publisher: 日本臨床社
• [Book] 臨床薬理第42巻第3号 (2011)
  • Author(s): 池田裕明
  • Publisher: 三原医学社
• [Book] CTL-がん免疫療法-実用化へのチャレンジ (2010)
  • Author(s): 池田裕明
  • Publisher: シーエムシー出版
• [Book] 遺伝子診断学 (2010)
  • Author(s): 池田裕明、今井奈緒子、珠玖洋
• [Book] SURGERY FRONTIER (2010)
  • Author(s): 今井奈緒子、池田裕明、岡本幸子、峰野純一、珠玖洋
• [Book] がん免疫療法-実用化へのチャレンジ- (2010)
  • Author(s): 池田裕明
  • Total Pages: 11
  • Publisher: シーエムシー出版
• [Book] 日本臨床増刊号 遺伝子診断学(第2版) 68巻増刊号 (2010)
  • Author(s): 池田裕明、今井奈緒子、珠玖洋
  • Total Pages: 7
  • Publisher: 日本臨床社
• [Book] SURGERY FRONTIER Vol.17 No.3 (2010)
  • Author(s): 今井奈緒子、池田裕明、岡本幸子、峰野純一、珠玖洋
  • Total Pages: 6
  • Publisher: メディカル レビュー社
• [Book] 免疫異常 (2009)
  • Author(s): 池田裕明、珠玖洋
  • Publisher: 中山書店
• [Book] 最新医学 (2009)
  • Author(s): 池田裕明
• [Book] 実験医学 (2009)
  • Author(s): 池田裕明、珠玖洋
• [Remarks]
  • URL: http://www.shikuken.jp/
• [Remarks]
  • URL: http://www.shikuken.jp
• [Remarks]
  • URL: http://www.shikuken.jp
• [Remarks]
  • URL: http://www.shikuken.jp
• [Patent(Industrial Property Rights)] T細胞の機能増強方法 (2010)
  • Inventor(s): 珠玖洋、池田裕明、岩村康一、峰野純一、加藤郁之進
  • Industrial Property Rights Holder: 国立大学法人三重大学、タカラバイオ株式会社
  • Filing Date: 2010-03-06
  • Overseas