| Project/Area Number |
21591666
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
UENO Takayuki 京都大学, 医学研究科, 助教 (40452362)
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| Co-Investigator(Kenkyū-buntansha) |
SUGIE Tomoharu 京都大学, 医学研究科, 准教授 (70335264)
YAMASHIRO Hiroyasu 京都大学, 医学研究科, 非常勤講師 (70402914)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 乳腺外科学 / ホルモン療法 / エネルギー調節 / アポトーシス / オートファジー / ミトコンドリア / 乳がん / 細胞死 / エネルギー代謝 / 術前療法 / がん幹細胞 / 術前両方 |
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| Research Abstract |
Endocrine therapy is a main therapeutic option for hormone receptor(HR)-positive breast cancer. De novo and acquired resistance to endocrine therapy is a hazard for efficient treatment of breast cancer, thus prediction and monitoring of therapeutic effect is critical. While suppression of proliferation by endocrine treatment has been well studied, cell death mode by endocrine therapy remains to be elucidated. The correlation between cell death mode and therapeutic effect was examined by using tissue specimens from the clinical trial with preoperative aromatase inhibitor treatment. Apoptosis markers did not show any change during treatment while autophagy markers increased by the treatment in both cancer cells and stromal cells. Increases in autophagy in cancer cells were associated with clinical effects of endocrine therapy, suggesting the involvement of autophagy in treatment effect by endocrine therapy, which may indicate that assessment of autophagic status might lead to detailed evaluation of therapeutic effects of endocrine treatment.
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