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Anti-cancer immunotherapy targeting toll-like receptors expressed on cancer cells and killer T cells

Research Project

Project/Area Number 21591668
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionShimane University

Principal Investigator

HARADA Mamoru  島根大学, 医学部, 教授 (50260716)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords癌 / 免疫療法 / Toll様受容体
Research Abstract

In this study, we revealed that apoptosis and growth arrest in a LNCaP human prostate cancer cell line can be induced by the addition of poly(I : C). In addition, transfection of poly(I : C) induced apoptosis and growth arrest in all three human breast cancer cell lines tested. Give that poly(I : C) can stimulate the immune response, these results indicate that poly(I : C) can induce anti-tumor effects and the stimulation of immune system simultaneously.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (64 results)

All 2012 2011 2010 2009 Other

All Journal Article (19 results) (of which Peer Reviewed: 17 results) Presentation (41 results) Remarks (4 results)

  • [Journal Article] Oral ingestion of Lentinula edodes mycelia extract can restore the antitumor T cell response of mice inoculated with colon-26 cells into the subserosal space of the cecum2012

    • Author(s)
      Harada M, et al.(5人中5番目)
    • Journal Title

      Oncology Reports

      Volume: 27 Pages: 325-332

    • DOI

      10.3892/or.2011.1549

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of the PI3 K/Akt pathway and autophagy in TLR3 sig naling-induced apoptosis and growth arr est of human prostate cancer cells2012

    • Author(s)
      Harashima, N., Inao, T., Imamura, R., et. al.
    • Journal Title

      Cancer Immunol. Immunother

      Volume: (in press) Issue: 5 Pages: 667-676

    • DOI

      10.1007/s00262-011-1132-1

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antitumor effects of cytoplasmic delivery of an innate adjuvant receptor ligand, poly(I : C), on human breast cancer2012

    • Author(s)
      Harada M., et al.(8人中8番目)
    • Journal Title

      Breast Cancer Research and Treatment

      Volume: (in press) Issue: 1 Pages: 89-100

    • DOI

      10.1007/s10549-011-1930-3

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Combining a peptide vaccine with oral ingestion of Lentinula edodes mycelia extract enhances anti-tumor activity in B16 melanoma-bearing mice2012

    • Author(s)
      Harada M., et al.(7人中7番目)
    • Journal Title

      Cancer Immunology Immunotherapy

      Volume: (in press)

    • URL

      http://www.springerlink.content/0340-7004.

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-17A is involved in enhancement of tumor progression in murine intestine2011

    • Author(s)
      K.Oshiro
    • Journal Title

      Immunobiology

      Volume: 217 Issue: 1 Pages: 54-60

    • DOI

      10.1016/j.imbio.2011.08.002

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Provision of continuous maturation signaling to dendritic cells by RIG-1-stimulating cytosolic RNA synthesis of Sendai virus2011

    • Author(s)
      Okano S,, et al
    • Journal Title

      J Immunol

      Volume: 186 Issue: 3 Pages: 1828-39

    • DOI

      10.4049/jimmunol.0901641

    • Related Report
      2011 Annual Research Report 2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral ingestion of Lentinus edodes mycelia extract inhibits B16 melanoma growth via mitigation of regulatory T cell-mediated immunosuppression2011

    • Author(s)
      Harada M, et al.(6人中6番目)
    • Journal Title

      Cancer Science

      Volume: 102 Issue: 3 Pages: 516-521

    • DOI

      10.1111/j.1349-7006.2010.01841.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oral ingestion of Lentinus edodes mycelia extract inhibits B16 melanoma growth via mitigation of regulatory T cell-mediated immunosuppression2011

    • Author(s)
      Tanaka K
    • Journal Title

      Cancer Science

      Volume: Vol.102 Pages: 516-521

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunogenic chemotherapy with cyclophophamide and doxorubicin against established murine carcinoma2010

    • Author(s)
      Harada M, et al.(5人中5番目)
    • Journal Title

      Cancer Immunology Immunotherapy

      Volume: 59 Issue: 5 Pages: 769-777

    • DOI

      10.1007/s00262-009-0797-1

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 'Sterile' inflammation and autophagy in cancer immunotherapy2010

    • Author(s)
      Harada M, Harashima N
    • Journal Title

      Immunotherapy

      Volume: 2 Issue: 5 Pages: 599-601

    • DOI

      10.2217/imt.10.55

    • Related Report
      2011 Final Research Report
  • [Journal Article] Immunogenic chemotherapy with cyclophosphamide and doxorubicin against established marine carcinoma2010

    • Author(s)
      Tongu M
    • Journal Title

      Cancer Immunology Immunotherapy

      Volume: Vol.59 Pages: 769-777

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 'Sterile' inflammation and autophagy in cancer immunotherapy2010

    • Author(s)
      Harada M
    • Journal Title

      Immunotheray

      Volume: Vol.2 Pages: 599-601

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Immunogenic chemotherapy with cyclophosphamide and doxorubicin against established murine carcinoma2010

    • Author(s)
      Tongu M
    • Journal Title

      Cancer Immunology Immunotherapy VOL.59

      Pages: 769-777

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Allogeneic cell therapy from immuniz ed donors with tumor antigen peptide enhances the antitumor effect after cyclophosphamide-using non-myeloabl ative allogeneic hematopoietic cell transplantation2009

    • Author(s)
      Hamaguchi M, Eto M 他8名
    • Journal Title

      Cancer Sci

      Volume: 100巻 Issue: 1 Pages: 138-143

    • DOI

      10.1111/j.1349-7006.2008.01014.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of proinflammatory cytokines and the Fas/FasL interaction in pathogenesis of inflammatory myopathies2009

    • Author(s)
      Harada M., et al.(8人中8番目)
    • Journal Title

      Immunology

      Volume: 128 Issue: 1pt2 Pages: 589-599

    • DOI

      10.1111/j.1365-2567.2008.03039.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to up-regulation of nitric oxide and IFN-production by tumor-associated macrophages2009

    • Author(s)
      Harada M, et al.(8人中8番目)
    • Journal Title

      Cancer Science

      Volume: 100 Issue: 11 Pages: 2160-2166

    • DOI

      10.1111/j.1349-7006.2009.01296.x

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Allogeneic cell therapy from immunized donors with tumor antigen peptide enhances the antitumor effect after cyclophosphamide-using non-myeloablative allogeneic hematopoietic cell transplantation in mice2009

    • Author(s)
      Hamaguchi M
    • Journal Title

      Cancer Science VOL.100

      Pages: 138-143

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roles of proinflammatory cytokines and the Fas/FasL interaction in pathogenesis of inflammatory myopathies2009

    • Author(s)
      Kondo M
    • Journal Title

      Immunology VOL.128

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Delayed growth of EL4 lymphoma in SR-A-deficient mice is due to up-regulation of nitric oxide and IFN-γ production by tumor-associated macrophages2009

    • Author(s)
      Komohara M
    • Journal Title

      Cancer Science VOL.100

      Pages: 2160-2166

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Role of autophagy in apoptosis of human cancer cells after stimulation through innate adjuvant receptor2011

    • Author(s)
      Harada Mamoru
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2011 Final Research Report
  • [Presentation] Apoptosis and ROS production in ploy(I : C)-transfected human renal cell carcinoma2011

    • Author(s)
      Harada Mamoru
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2011 Final Research Report
  • [Presentation] Neoadjuvant immunotherapy using IL12/DC for control of recurrent hepatocellular carcinoma in immunosppressed mice2011

    • Author(s)
      Harada Mamoru
    • Organizer
      第70回日本癌学会総会,第40回日本免疫学会総会
    • Place of Presentation
      幕張メッセ(千葉)
    • Related Report
      2011 Final Research Report
  • [Presentation] 移植後肝細胞癌再発抑制におけるIL-12と樹状細胞を用いた術前補助免疫療法の抗腫瘍効果の検討2011

    • Author(s)
      原田守
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋コングレスセンター(名古屋)
    • Related Report
      2011 Final Research Report
  • [Presentation] Lentinula edodes mycelia抽出物の予防的経口摂取はTreg抑制を介してワクチンによる抗癌効果を増強する2011

    • Author(s)
      原田守
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋コングレスセンター(名古屋)
    • Related Report
      2011 Final Research Report
  • [Presentation] Lentinula edodes mycelia抽出物の経口摂取はTreg抑制により抗癌ペプチドワクチン効果を増強・持続させる2011

    • Author(s)
      原田守
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋コングレスセンター(名古屋)
    • Related Report
      2011 Final Research Report
  • [Presentation] TregとMDSCをターゲットとしたシクロホスファマイドとゲムシタビンの間欠投与による化学療法2011

    • Author(s)
      原田守
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋コングレスセンター(名古屋)
    • Related Report
      2011 Final Research Report
  • [Presentation] Poly(I : C)トランスフェクションによるヒト乳癌細胞に対する抗がん効果とオートファジー2011

    • Author(s)
      原田守
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋コングレスセンター(名古屋)
    • Related Report
      2011 Final Research Report
  • [Presentation] Neoadjuvant immunotherapy using IL12/DC for control of recurrent hepatocellular carcinoma in immunosuppressed mice2011

    • Author(s)
      原田守
    • Organizer
      第15回日がん免疫学会総会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Related Report
      2011 Final Research Report
  • [Presentation] 乳癌細胞に発現するアジュバント受容体を利用したimmunogenic cancer cell deathの誘導2011

    • Author(s)
      原田守
    • Organizer
      第15回日がん免疫学会総会
    • Place of Presentation
      千里ライフサイエンスセンター(大阪)
    • Related Report
      2011 Final Research Report
  • [Presentation] 乳癌細胞に発現するアジュバント受容体を利用したimmunogenic cancer cell deathの誘導2011

    • Author(s)
      原嶋奈々江
    • Organizer
      第15回日がん免疫学会総会
    • Place of Presentation
      大阪(千里ライフサイエンスセンター)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neoadjuvant immunotherapy using IL12/DC for control of recurrent hepatocellular carcinoma in immunosuppressed mice2011

    • Author(s)
      岡野慎士
    • Organizer
      第15回日がん免疫学会総会
    • Place of Presentation
      大阪(千里ライフサイエンスセンター)
    • Related Report
      2011 Annual Research Report
  • [Presentation] poly(I:C)トランスフェクションによるヒト乳癌細胞に対する抗がん効果とオートファジー2011

    • Author(s)
      稲尾瞳子
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋(名古屋コングレスセンター)
    • Related Report
      2011 Annual Research Report
  • [Presentation] TregとMDSCをターゲットとしたシクロホスファマイドとゲムシタビンの間欠投与による化学療法2011

    • Author(s)
      頓宮美樹
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋(名古屋コングレスセンター)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Lentinula edodes mycelia抽出物の経口摂取はTreg抑制により抗癌ペプチドワクチン効果を増強・持続させる2011

    • Author(s)
      田中公輔
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋(名古屋コングレスセンター)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Lentinula edodes mycelia抽出物の予防的経口摂取はTreg抑制を介してワクチンによる抗癌効果を増強する2011

    • Author(s)
      石川悟
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋(名古屋コングレスセンター)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 移植後肝細胞癌再発抑制におけるIL-12と樹状細胞を用いた術前補助免疫療法の抗腫瘍効果の検討2011

    • Author(s)
      岡野慎士
    • Organizer
      第70回日本癌学会総会
    • Place of Presentation
      名古屋(名古屋コングレスセンター)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neoadjuvant immunotherapy using IL12/DC for control of recurrent hepatocellular carcinoma in immunosppressed mice2011

    • Author(s)
      Okano S
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      千葉(幕張メッセ)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Apoptosis and ROS production in ploy(I:C)-transfected human renal cell carcinoma2011

    • Author(s)
      Harashima N
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      千葉(幕張メッセ)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of autophagy in apoptosis of human cancer cells after stimulation throush innate adjuvant receptor2011

    • Author(s)
      Harada M
    • Organizer
      第40回日本免疫学会総会
    • Place of Presentation
      千葉(幕張メッセ)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Induction of apoptosis and growth arrest of human breast cancer cells by targeting a cytoplasmic RIG-I-like receptor2010

    • Author(s)
      Harada Mamoru
    • Organizer
      The 20^<th> HCS-The three Universities' Consortium International Symposium
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2010-10-31
    • Related Report
      2011 Final Research Report
  • [Presentation] シイタケ菌糸体抽出物によるTreg免疫抑制の解除を介した腫瘍特異的CTLの誘導2010

    • Author(s)
      原田守
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2011 Final Research Report
  • [Presentation] リコンビナントセンダイウイルスによるRIG-1刺激性細胞内RNA合成はヒト樹状細胞の新規刺激剤である2010

    • Author(s)
      原田守
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2011 Final Research Report
  • [Presentation] Poly(I : C)のトランスフェクションによるヒト乳癌細胞でのアポトーシスとオートファジーの誘導2010

    • Author(s)
      原田守
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2011 Final Research Report
  • [Presentation] Provision of continuous maturation signaling to dendritic cells(DC) by RIG-1-stimulating cytosolic RNA synthesis of recombinant Sendai virus(rSeV)2010

    • Author(s)
      Harada Mamoru
    • Organizer
      国際免疫学会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Related Report
      2011 Final Research Report
  • [Presentation] TLR3 ligand-induced apoptotic cell death with autophagy and growth arrest in human prostate cancer cells2010

    • Author(s)
      Harada Mamoru
    • Organizer
      国際免疫学会
    • Place of Presentation
      神戸国際会議場(神戸)
    • Related Report
      2011 Final Research Report
  • [Presentation] TLR3シグナルはPI3K/Akt経路の不活化を介してヒト前立腺癌細胞に細胞死と増殖抑制を誘導する2010

    • Author(s)
      原田守
    • Organizer
      第14回日本がん免疫学会総会
    • Place of Presentation
      ホテル熊本(熊本)
    • Related Report
      2011 Final Research Report
  • [Presentation] RIG-1-stimulating cytosolic RNA synthesis of Sendai virus(rSeV) is a novel stimulant for human dendritic cells2010

    • Author(s)
      原田守
    • Organizer
      第14回日本がん免疫学会総会
    • Place of Presentation
      ホテル熊本(熊本)
    • Related Report
      2011 Final Research Report
  • [Presentation] RIG-I-stimulating cytosolic RNA synthesis of Sendai virus is a novel stimulant for human dendritic cells2010

    • Author(s)
      岡野慎二
    • Organizer
      第14回日本がん免疫学会
    • Place of Presentation
      熊本
    • Related Report
      2010 Annual Research Report
  • [Presentation] TLR3シグナルはPI3K/Akt経路の不活化を介してヒト前立腺癌細胞に細胞死と増殖抑制を誘導する2010

    • Author(s)
      原嶋奈々江
    • Organizer
      第14回日本がん免疫学会
    • Place of Presentation
      熊本
    • Related Report
      2010 Annual Research Report
  • [Presentation] TLR3 ligand-induced apoptotic cell death with autophagy and growth arrest in human prostate cancer cells2010

    • Author(s)
      Harashima N
    • Organizer
      第14回国際免疫学会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Provision of continuous maturation signaling to dendritic cells by RIG-I-stimulating cytosolic RNA synthesis pf recombinant Sendai virus2010

    • Author(s)
      Okano S
    • Organizer
      第14回国際免疫学会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Poly(I:C)のトランスフェクションによるヒト乳癌細胞でのアポトーシスとオートファジーの誘導2010

    • Author(s)
      稲尾瞳子
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] リコンビナントセンダイウイルスによるRIG-I刺激性細胞内RNA合成はヒト樹状細胞の新規刺激剤である2010

    • Author(s)
      岡野慎二
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] シイタケ菌糸体抽出物によるTreg免疫抑制の解除を介した腫瘍特異的CTLの誘導2010

    • Author(s)
      田中公輔
    • Organizer
      第69回日本癌学会総会
    • Place of Presentation
      大阪
    • Related Report
      2010 Annual Research Report
  • [Presentation] TLR3 ligand-induced apoptosis of prostate cancer cells2009

    • Author(s)
      Mamoru Harada
    • Organizer
      第39回日本免疫学会総会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2011 Final Research Report
  • [Presentation] TLR3 ligand-induced prostate cancer cell death through endogenous production of type I IFN2009

    • Author(s)
      Harada Mamoru
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2011 Final Research Report
  • [Presentation] Immunogenic chemotherapy with cyclophosphamide and adriamycin against established murine colon carcinoma2009

    • Author(s)
      原田守
    • Organizer
      第13回日本がん免疫学会総会
    • Place of Presentation
      北九州国際会議場(北九州)
    • Related Report
      2011 Final Research Report
  • [Presentation] Immunogenic chemotherapy with cyclophosphamide and adriamycin against established murine colon carcinoma2009

    • Author(s)
      原田守
    • Organizer
      第13回日本がん免疫学会総会
    • Place of Presentation
      北九州
    • Related Report
      2009 Annual Research Report
  • [Presentation] TLR3 ligand-induced prostate cancer cell death through endogenous production of type I IFN2009

    • Author(s)
      Harashima N
    • Organizer
      第68回日本癌学会総会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] TLR3 ligand-induced apoptosis of prostate cancer cells2009

    • Author(s)
      Harada M
    • Organizer
      第39回日本免疫学会総会
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.med.shimane-u.ac.jp/immunology/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.med.shimane-u.ac.jp/immunology/index.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.shimane-u.ac.jp/immunolgy/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.shimane-u.ac.jp/immunology/index.html

    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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