Study for mechanism of cell cycle regulation by ubiquitin ligase in triple-negative breast cancer

• Project/Area Number: 21591671
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Kumamoto University
• Principal Investigator: YAMAMOTO Yutaka 熊本大学, 大学院・生命科学研究部, 助教 (20398217)
• Co-Investigator(Kenkyū-buntansha): IWASE Hirotaka 熊本大学, 大学院・生命科学研究部, 教授 (40211065)
• Research Collaborator: IBUSUKI Mutsuko 熊本大学, 大学院・生命科学研究部, 助教 (30448526)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 乳腺外科学 / ユビキチンリガーゼ / Fbw7 / skp2 / 乳癌 / トリプルネガティブ乳癌 / Skp2 / 予後因子 / 細胞周期

Research Abstract

We studied clinical significance of ubiquitin ligase(skp2 and Fbw7) in breast cancer and potential of ubiquitin ligase targeting-therapy for breast cancer. Fbw7 downregulation and skp2 overexpression were significantly correlated with aggressive phenotype in breast cancer. Fbw7 knockdown led to suppression of proliferation in breast cancer cells.

Research Products

• [Journal Article] Reduced expression of ubiquitin ligase FBXW7 mRNA is associated with poor prognosis in breast cancer patients (2011)
  • Author(s): Ibusuki M, Yamamoto Y, Shinriki S, Ando Y, Iwase H
  • Journal Title: Cancer Sci Volume: 102(2) Pages: 439-45
  • NAID: 10029290404
  • Peer Reviewed
• [Journal Article] Reduced expression of ubiquitin ligase FBXW7 mRNA is associated with poor prognosis in breast cancer patients. (2011)
  • Author(s): Ibusuki M, Yamamoto Y, Shinriki S, et al.
  • Journal Title: Cancer Science Volume: 102 Pages: 439-445
  • NAID: 10029290404
  • Peer Reviewed
• [Journal Article] Clinicopathological features and treatment strategy for triple-negative breast cancer (2010)
  • Author(s): Yamamoto Y, Iwase H
  • Journal Title: Int J Clin Oncol Volume: 15(4) Pages: 341-51
  • NAID: 10026601200
  • Peer Reviewed
• [Journal Article] Clinicopathological features and treatment strategy for triple-negative breast cancer. (2010)
  • Author(s): Yamamoto Y, Iwase H
  • Journal Title: International Journal of Clinical Oncology Volume: 15 Pages: 341-351
  • NAID: 10026601200
  • Peer Reviewed
• [Journal Article] Clinical significance of basal-like subtype in triple-negative breast cancer (2009)
  • Author(s): Yamamoto Y, Ibusuki M, Iwase H, et al
  • Journal Title: Breast Cancer VOL.16 Pages: 260-270
  • NAID: 10027254696
  • Peer Reviewed
• [Presentation] Redu ced expression of ubiquitin ligase FB XW7 mRNA is associated with poor prog nosis in breast cancer patients (2011)
  • Author(s): Ibusuki M, Yamamoto Y, Iwase H
  • Organizer: Adva nces in Breast Cancer Research
  • Place of Presentation: サンフランシスコ、米国
  • Year and Date: 2011-10-14
• [Presentation] Reduced expression of ubiquitin ligase FBXW7 mRNA is associated with poor prognosis in breast cancer patients (2011)
  • Author(s): 指宿睦子、山本豊、岩瀬弘敬
  • Organizer: Advances in Breast Cancer Research
  • Place of Presentation: 米国サンフランシスコ