| Project/Area Number |
21591672
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tokai University (2010-2011)
Oita University (2009) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
INAGAKI Yutaka 東海大学, 医学部, 教授 (80193548)
MATSUO Noritaka 大分大学, 医学部, 准教授 (10284788)
YOSHIOKA Hidekatsu 大分大学, 医学部, 教授 (00222430)
HAMANAKA Ryouji 大分大学, 医学部, 助教 (60274750)
OKAMOTO Osamu 大分大学, 医学部, 講師 (40284799)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 実験外科学 / 癒着防止 / 抗線維化 / V型コラーゲンα3鎖 / 組織線維化 / コラーゲン発現調節 |
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| Research Abstract |
Organ adhesion were one case of excess tissue fibrosis caused wound healing after operation. Organ adhesion has bad influences for functional recovery and patients QOL. In this study elucidated that, minor component of collagen Type Vα3 chain(α3(V)) has anti tissue adhesion and fibrosis activity and specific expression in early time wound tissue. Inα3(V) rich regions collagen fiber observed thin and soft shapes. The idea forα3(V) anti-fibrosis activity were inhibited collagen banding step directly for any data from this study.α3(V) could very promising material for organ adhesion blocking treatment.
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