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Estrogen receptor knock down therapy using microRNA for breast cancer patients

Research Project

Project/Area Number 21591674
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General surgery
Research InstitutionNagoya City University

Principal Investigator

TOYAMA Tatsuya  名古屋市立大学, 大学院・医学研究科, 准教授 (30315882)

Co-Investigator(Kenkyū-buntansha) YAMASHITA Hiroko  名古屋市立大学, 大学院・医学研究科, 准教授 (70332947)
SUGIURA Hiroshi  名古屋市立大学, 大学院・医学研究科, 研究員 (20381882)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords乳癌 / マイクロRNA / エストロゲン・レセプター / miR-206 / エストロゲン・レセプターα
Research Abstract

Several microRNAs(miRNAs) that directly target ERα have been identified. In this study, expression levels of miRNAs that directly target ERα, including miR-18a, miR-18b, miR-22, miR-193b, miR-206, miR-221/222 and miR-302c, were analyzed in human breast cancer samples by quantitative reverse transcription-PCR analysis. Correlations between the expression levels of these miRNAs and clinicopathological factors were analyzed. miR-18a expression was much higher in ERα-negative than in ERα-positive tumors, with the expression levels of miR-18a not differing in ERα-positive breast cancer as a function of ERαprotein level. Surprisingly, the expression levels of miR-193b and miR-221 were significantly lower in ERα-negative than in ERα-positive tumors, and the levels of these miRNAs gradually increased as ERα protein expression increased. Our results suggest that miR-206 could be a novel candidate for endocrine therapy that targets only ERα in breast cancer.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (6 results)

All 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (3 results) Remarks (1 results)

  • [Journal Article] Distinct expressions of microRNAs that directly target estrogen receptor α in human breast cancer2011

    • Author(s)
      Yoshimoto N, Toyama T, Takahashi S, Sugiura H, Endo Y, Iwasa M, Fujii Y, Yamashita H
    • Journal Title

      Breast Cancer Res Treat

      Volume: 130(1) Pages: 331-9

    • Related Report
      2011 Final Research Report
  • [Journal Article] Distinct expressions of microRNAs that directly target estrogen receptor α in human breast cancer2011

    • Author(s)
      Yoshimoto N, Toyama T, et al
    • Journal Title

      Breast Cancer Res Treat

      Volume: 131 Issue: 1 Pages: 331-339

    • DOI

      10.1007/s10549-011-1672-2

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Low Expression of microRNA-210 Is an Independent Good Prognostic Factor in Japanese Triple-Negative Breast Cancer Patients2011

    • Author(s)
      Toyama T, Kondo N, Endo Y, Sugiura H, Yoshimoto N, Iwasa M, Takahashi S, Iwase H, Fujii Y, Yamashita H
    • Organizer
      34rd Annual San Antonio Breast Cancer Symposium
    • Place of Presentation
      San Antonio, USA
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Distinct expressions of microRNAs that directly target estrogen receptor in human breast cancer2011

    • Author(s)
      Yamashita H, Yoshimoto N, Toyama T, Takahashi S, Sugiura H, Endo Y, Iwasa M, Fujii Y
    • Organizer
      Advances in Breast Cancer Research, American Association for Cancer Research(AACR) Special Conference in Cancer Research
    • Place of Presentation
      San Francisco, U. S. A.
    • Related Report
      2011 Final Research Report
  • [Presentation] 乳癌のエストロゲンレセプターαの発現調節に関与するmicroRNAの解析2011

    • Author(s)
      吉本信保、遠山竜也、杉浦博士、遠藤友美、岩佐麻衣、藤井義敬、山下啓子
    • Organizer
      第111回日本外科学会定期学術集会
    • Place of Presentation
      東京
    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.med.nagoya-cu.ac.jp/mammal.dir/index.html

    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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