Cooperation of cancer stem cell properties and epithelial-Mesenchymal transition in chemosensitivity in breast cancer

Research Project

Project/Area Number	21591677
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	General surgery
Research Institution	Keio University
Principal Investigator	TAKAHASHI Maiko 慶應義塾大学, 医学部, 助教 (50348661)
Co-Investigator(Kenkyū-buntansha)	HAYASHIDA Tetsu 慶應義塾大学, 医学部, 助教 (80327543)
Project Period (FY)	2009 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	癌幹細胞 / EMT / 化学療法感受性 / PSK / 乳癌 / 化学療法耐性 / ALDH / マウス異種移植モデル / 抗癌剤耐性
Research Abstract	We recently screened for novel TGF-b inhibitors among commercially available drugs and identified PSK as a strong inhibitor of the TGF-β-induced reporter activity of 3TP-lux. PSK suppressed TGF-β1-induced EMT, and FACS analysis showed that PSK inhibited the EMT-mediated generation of CD44+/CD24-cells.

Report

(4 results)