Cooperation of cancer stem cell properties and epithelial-Mesenchymal transition in chemosensitivity in breast cancer
Project/Area Number |
21591677
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
General surgery
|
Research Institution | Keio University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
HAYASHIDA Tetsu 慶應義塾大学, 医学部, 助教 (80327543)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 癌幹細胞 / EMT / 化学療法感受性 / PSK / 乳癌 / 化学療法耐性 / ALDH / マウス異種移植モデル / 抗癌剤耐性 |
Research Abstract |
We recently screened for novel TGF-b inhibitors among commercially available drugs and identified PSK as a strong inhibitor of the TGF-β-induced reporter activity of 3TP-lux. PSK suppressed TGF-β1-induced EMT, and FACS analysis showed that PSK inhibited the EMT-mediated generation of CD44+/CD24-cells.
|
Report
(4 results)
Research Products
(4 results)