| Project/Area Number |
21591680
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Aichi Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKANO Shogo 愛知医科大学, 医学部, 准教授 (20351108)
YOROZUYA Kyoko 愛知医科大学, 医学部, 講師 (90297359)
FUKUTOMI Takashi 愛知医科大学, 医学部, 教授 (30165302)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 生体材料 / 癌 / 循環血液中腫瘍細胞 / SHAP-HA複合体 / CD44 / 細胞間質 / 接着因子 |
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| Research Abstract |
During cancer progression, Hyaluronan(HA), which is a linear polymer of simply repeated N-acetyl glucosamine-glucuronic acid disaccharide units, assembles an extracellular matrix that is favorable for both motility and proliferation of cancer cells. Serum-derived hyaluronan-associated protein(SHAP), which forms covalent linkages with HA(SHAP-HA complex), stimulates to form tumor microenvironment which is formed by HA.
We firstly recognized the accumulation of both HA and SHAP in breast cancer specimen. Marked aggregation of both HA and SHAP was identified in the stroma around the cancer nest by immunohistochemical staining of the fixed specimen. Serum level of SHAP-HA complexes was elevated with the progression of the primary cancer staging. We concluded that SHAP modification of HA may have an important role in tumor proliferation.
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