Inhibitory study on lymnph node metastasis of mammary cancer by SATB1 and VEGF-C siRNA and decoy vectors
| Project/Area Number |
21591682
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Osaka Health Science University (2010-2011)
Osaka Medical College (2009) |
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Principal Investigator |
SHIBTA Masa-aki 大阪保健医療大学, 保健医療学部, 教授 (10319543)
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| Co-Investigator(Kenkyū-buntansha) |
MORIMOTO Junji 大阪医科大学, 医学部, 講師 (90145889)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 乳腺外科学 / 乳癌 / 遺伝子治療 / SATB1 / VEGFR3 / デコイベクター / VEGF-C / リンパ節転移 / siRNA / リンパ管新生 / リンパ転移 / VEGFR-3デコイ / 転移 / 抗腫瘍効果 |
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| Research Abstract |
SATB1 that enhances growth and metastasis of breast cancer was blocked by siRNA. A decoy vector for VEGFR-3(receptor for VEGF-C) reduces VEGF-C function(anti-lymphangiogenesis) VEGFR-3 decoy but not Satb1 siRNA can inhibit mainly lymph node metastasis on mouse mammary cancer model. The antimetastatic activity of VEGFR-3 decoy may be of high clinical significance.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] The endogenous soluble VEGF receptor-2 isoform suppresses lymph node metastasis in a mouse immunocompetent mammary cancer model2010
Author(s)
Shibata, M. A., Ambati, J., Shibata, E., Albuquerque, R. J., Morimoto, J., Ito, Y. and Otsuki, Y.
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Journal Title
Related Report
Peer Reviewed
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