| Project/Area Number |
21591683
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kansai Medical University |
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Principal Investigator |
TSUBURA Airo 関西医科大学, 医学部, 教授 (90098137)
|
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| Co-Investigator(Kenkyū-buntansha) |
UEHARA Norihisa 関西医科大学, 医学部, 講師 (30368211)
YURI Takashi 関西医科大学, 医学部, 講師 (50330212)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | スルフォラファン / 乳癌 / アポトーシス / オートファジー / 細胞死 / バフィロマイシン / 3-メチルアデニン / sulforaphane / Mammary / Breast / Apoptosis / Autophagy / Cell death / Bafilomycin A1 |
|---|
| Research Abstract |
Sulforaphane(SFN) significantly inhibited primary tumor growth and tended to reduce axillary lymph node metastasis of KPL-1 human breast cancer cell xenografts in female athymic mice with no side effects. The involvement of autophagy in the SFN-induced apoptotic cell death of MCF-7 and MDA-MB-231 human breast cancer cells was cytoprotective. Therefore, SFN is safe and the combination of SFN with autophagy inhibitor may be a promising strategy for breast cancer control.
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