Molecular mechanism of solid tumor growth inhibition by a new differentiation inducer and rapamycin

• Project/Area Number: 21591686
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General surgery
• Research Institution: Research Institute for Clinical Oncology, Saitama Cancer Center
• Principal Investigator: KASUKABE Takashi 埼玉県立がんセンター, 臨床腫瘍研究所, 主幹 (50152658)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: Cotylenin A / Rapamycin / 分化誘導剤 / 乳癌細胞 / 増殖抑制 / 併用効果 / Aktリン酸化 / mTOR / 三酸化ヒ素 / アポトーシス / 卵巣癌細胞 / セルシグナリング / Akt

Research Abstract

We have examined whether a new differentiation inducer of leukemic cells can suppress the proliferation of solid tumor cells. We recently found that cotylenin A and rapamycin synergistically inhibited the growth of human mammary cancer cells in vitro and in vivo. In this study we found that the abrogation by cotylenin of the rapamycin-induced feedback activation of Akt signaling contributed, at least in part, to the synergistic growth inhibition of mammary cancer cells induced by treatment with cotylenin A and rapamycin.

Research Products

• [Journal Article] Extracellular NM23 protein as a therapeutic target for hematological malignancy (2012)
  • Author(s): Okabe-Kado, J., Kasukabe, T., Kaneko, Y.
  • Journal Title: Adv. Hematol Volume: 2012 Pages: 879368-879368
  • Peer Reviewed
• [Journal Article] Extracellular NM23 protein as a therapeutic target for hematological malignancy (2012)
  • Author(s): Okabe-Kado J, Kasukabe T
  • Journal Title: Adv.Hematol. Volume: 2012 Pages: 879368-879368
  • DOI: 10.1155/2012/879368
  • Peer Reviewed
• [Journal Article] Ellagic acid, a natural polyphenolic compound, induces apoptosis and potentiates retinoic acid-induced differentiation of human leukemia HL-60 cells (2010)
  • Author(s): Hagiwara, Y., Kasukabe, T., Kaneko, Y., Niitsu, N., Okabe-Kado, J.
  • Journal Title: J. Hematol Volume: 92 Pages: 136-143
  • NAID: 10026512237
  • Peer Reviewed
• [Journal Article] Ellagic acid, a natural polyphenolic compound, induces apo-ptosis and potentiates retinoic acid-induced differentiation of human leukemia cells. (2010)
  • Author(s): Hagiwara Y, Kasukabe T
  • Journal Title: Int.J.Hematol. Volume: 92 Pages: 136-143
  • Peer Reviewed
• [Journal Article] Extracellular NM23 protein promotes the growth and survival of primary cutured human acute myelogenous leukemia cells (2009)
  • Author(s): Okabe-Kado, J., Kasukabe, T., Honma, Y., Kobayashi, H., Kaneko, Y.
  • Journal Title: Cancer Sci Volume: 100 Pages: 1885-1894
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): Okabe-Kado, J., Kasukabe, T., Honma, Y., Kobayashi, H., Maseki, N., Kaneko, Y
  • Journal Title: Int. J. Hematol Volume: 90 Pages: 143-152
  • Peer Reviewed
• [Journal Article] Extracellular NM23 protein promotes the growth and survival of primary cultured human acute myelogenous leukemia cell (2009)
  • Author(s): Okabe-Kado J., Kasukabe T
  • Journal Title: Cancer Science 100 Pages: 1885-1894
  • NAID: 10027195731
  • Peer Reviewed
• [Journal Article] Extracellular NM23-H1 protein inhibits the survival of primary cultured normal human peripheral blood mononuclear cells and activates the cytokine production (2009)
  • Author(s): Okabe-Kado J., Kasukabe T
  • Journal Title: Int.J.Hematol. 90 Pages: 143-152
  • NAID: 10026108191
  • Peer Reviewed
• [Presentation] Cotylenin A potentiates arsenic trioxide-induced apoptosis in human breast cancer cells (2011)
  • Author(s): 粕壁隆, 他2名
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-04
• [Presentation] Cotylenin A potentiates arsenic trioxide-induced apoptosis in human breast cancer cells (2011)
  • Author(s): 粕壁隆
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2011-10-04
• [Presentation] PI-103 and cotylenin A synergistically inhibit growth of rapamycin-sensitive and-resistant mammary cancer cells (2010)
  • Author(s): 粕壁隆, 他2名
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-09-23
• [Presentation] PI-103 and cotylenin A synergistically inhibit growth of rapamycin-sensitive and -resistant mammary cancer cells. (2010)
  • Author(s): 粕壁隆
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: 大阪国際会議場(大阪府)
  • Year and Date: 2010-09-23
• [Presentation] Rapamycin and arsenic trioxide synergistically induce apoptosis of human ovarian cancer cells (2009)
  • Author(s): 粕壁隆, 他3名
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02
• [Presentation] Rapamycin and arsenic trioxide synergistically induce apoptosis of human ovarian cancer cells (2009)
  • Author(s): 粕壁隆
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(神奈川県)
  • Year and Date: 2009-10-02
• [Remarks]
  • URL: http://www.pref.saitama.lg.jp/A80/BA02/top.htm
• [Remarks]
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• [Remarks]
  • URL: http://www.pref.saitama.lg.jp/A80/BA02/top.htm
• [Remarks]
  • URL: http://www.pref.saitama.lg.jp/A80/BA02/top.htm