A trial for the improvement of the result of esophageal cancer surgery by molecular chaperone HSP overexpression

• Project/Area Number: 21591690
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Gunma University
• Principal Investigator: TAKAHASHI Atsushi 群馬大学, 医学部, 准教授 (00323337)
• Co-Investigator(Kenkyū-buntansha): TSUTSUMI Soichi 群馬大学, 大学院・医学系研究科, 助教 (30323356) ; MOCHIKI Erito 群馬大学, 医学部, 講師 (80312883)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: Hsp70 / Hsp70抗体 / ELISA / HSP110 / 抗Hsp70抗体

Research Abstract

Serum Anti-Hsp70 antibody levels in esophageal cancer patients were measured, and the relationship with post-operative mortality was analyzed. Mean anti-Hsp70 antibody levels was 191.1μg/ml. Therefore, the patients whose anti-Hsp70 antibody concentration. 191

Research Products

• [Journal Article] Prognostic significanceof heat shock protein 110 expressionand T lymphocyte infiltration inesophageal cancer (2011)
  • Author(s): Nakajima M, Kato H, Miyazaki T, FukuchiM, Masuda N, Fukai Y, Sohda M, Inose T, Sakai M, Sano A, Tanaka N, Ahmad F, Kuwano H.
  • Journal Title: Hepatogastroenterology Volume: 58 Pages: 1555-1560
  • Peer Reviewed
• [Journal Article] Cell to cell interaction in clusters enhances thermosensitivity in HT29 human coloncancer cells (2011)
  • Author(s): Yamauchi H, Asao T, Yazawa S, Kigure W, Morita H, Kobayashi T, Kato T, Yajima R, Tabe Y, Yamaki S, Fukasawa T, Fujii T, Tsutsumi S, Kuwano H.
  • Journal Title: Hepatogastroenterology Volume: 58 Pages: 1958-62
  • Peer Reviewed
• [Journal Article] TNFAIP8O verexpression : Clinical Relevance to Esophageal Squamous Cell Carcinoma. (2011)
  • Author(s): Hadisaputri YE, Miyazaki T, Suzuki S, Yokobori T, Kobayashi T, Tanaka N, Inose T, Sohda M, Kuwano H.
  • Journal Title: Ann Surg Oncol Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Development of anexperimental model of cholestasis induced by hypoxia/ischemic damage to the bile duct and liver tissues in infantile rats (2011)
  • Author(s): Toki F, Takahashi A, Suzuki M, OotakeS, Hirato J, Kuwano H
  • Journal Title: J Gastroenterol Volume: 46(5) Pages: 639-647
  • Peer Reviewed
• [Journal Article] Prognostic significance of heat shock protein 110 expression and T lymphocyte infiltration in esophageal cancer (2011)
  • Author(s): Nakajima M, Kato H, Miyazaki T, Fukuchi M, Masuda N, Fukai Y, Sohda M, Inose T, Sakai M, Sano A, Tanaka N, Ahmad F, Kuwano H
  • Journal Title: Hepatogastroenterology Volume: 58 Pages: 1555-1560
  • Peer Reviewed
• [Journal Article] Cell to cell interaction in clusters enhances thermosensitivity in HT29 human colon cancer cells (2011)
  • Author(s): Yamauchi H, Asao T, Yazawa S, Kigure W, Morita H, Kobayashi T, Kato T, Yajima R, Tabe Y, Yamaki S, Fukasawa T, Fujii T, Tsutsumi S, Kuwano H
  • Journal Title: Hepatogastroenterology Volume: 58 Issue: 112 Pages: 1958-1962
  • DOI: 10.5754/hge11208
  • Peer Reviewed
• [Journal Article] TNFAIP8 Overexpression : Clinical Relevance to Esophageal Squamous Cell Carcinoma (2011)
  • Author(s): Hadisaputri YE, Miyazaki T, Suzuki S, Yokobori T, Kobayashi T, Tanaka N, Inose T, Sohda M, Kuwano H
  • Journal Title: Ann Surg Oncol Volume: (Epub ahead of print) Issue: S3 Pages: 589-596
  • DOI: 10.1245/s10434-011-2097-1
  • Peer Reviewed
• [Journal Article] Time-coursechanges in the liver of biliary atresia patients on magnetic resonance imaging (2009)
  • Author(s): Takahashi A, Hatakeyama S, Kuroiwa M, Suzuki N, Toki F, Suzuki M, Suehiro T, Shimura T, Kuwano H
  • Journal Title: Pediatr Int Volume: 51 Pages: 66-70
  • Peer Reviewed
• [Journal Article] Tumor immune systems inesophageal cancer with special reference to heat-shock protein 70 andhumoral immunity (2009)
  • Author(s): Nakajima M, Kato H, Miyazaki T, FukuchiM, Masuda N, Fukai Y, Sohda M, Ahmad F, Kuwano H
  • Journal Title: Anticancer Res Volume: 29 Pages: 1595-606
  • Peer Reviewed
• [Journal Article] Tumor immune systems in esophageal cancer with special reference to heat-shock protein 70 and humoral immunity. (2009)
  • Author(s): Nakajima M, et al
  • Journal Title: Anticancer Res 29 Pages: 1595-606
  • Peer Reviewed
• [Presentation] 食道・胃接合部癌の治療方針に対する臨床病理学的検討 (2011)
  • Author(s): 中島政信, 室井大人, 志田陽介, 菅原学, 円谷美也子, 田中成岳, 宗田真, 宮崎達也, 桑野博行, 加藤広行
  • Organizer: 第66回日本消化器外科学会総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-07-15
• [Presentation] 食道癌の周術期管理第1回とちぎ外科教育セミナー (2011)
  • Author(s): 中島政信
  • Place of Presentation: 宇都宮
  • Year and Date: 2011-01-28
• [Presentation] ハイリスク食道癌における手術治療の検討 (2010)
  • Author(s): 宗田真, 宮崎達也, 鈴木茂正, 田中成岳, 酒井真, 佐野彰彦, 猪瀬崇徳, 中島政信, 福地稔, 桑野博行
  • Organizer: 第48回日本癌治療学会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-29
• [Presentation] パネルディスカッション、ハイリスク食道癌における手術治療の検討 (2010)
  • Author(s): 宗田真、宮崎達也、鈴木茂正、田中成岳、酒井真、佐野彰彦、猪瀬崇徳、中島政信、福地稔、桑野博行
  • Organizer: 第48回日本癌治療学会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2010-10-29
• [Presentation] 合併症軽減を目指した食道癌根治術の周術期管理 (2010)
  • Author(s): 中島政信, 田中成岳, 酒井真, 佐野彰彦, 猪瀬崇徳, 家田敬輔, 宗田真, 宮崎達也, 加藤広行, 桑野博行
  • Organizer: 第64回日本食道学会学術集会
  • Place of Presentation: 久留米
  • Year and Date: 2010-08-31
• [Presentation] 食道・胃接合部癌およびバレット食道癌の治療法に関する検討 (2010)
  • Author(s): 中島政信, 鈴木茂正, 田中成岳, 酒井真, 佐野彰彦, 猪瀬崇徳, 宗田真, 高橋雅一, 円谷美也子, 宮崎達也, 加藤広行, 桑野博行
  • Organizer: 第65回日本消化器外科学会総会
  • Place of Presentation: 下関
  • Year and Date: 2010-07-15
• [Presentation] Barrett食道癌に対する手術治療の検討 (2009)
  • Author(s): 中島政信, 田中成岳, 酒井真, 佐野彰彦, 猪瀬崇徳, 宗田真, 宮崎達也, 増田典弘, 福地稔, 加藤広行, 桑野博行
  • Organizer: 第71回日本臨床外科学会総会
  • Place of Presentation: 京都
  • Year and Date: 2009-11-21
• [Presentation] 臨床病理学的特長からみた食道・胃接合部癌の治療法に関する検討 (2009)
  • Author(s): 中島政信, 田中成岳, 酒井真, 佐野彰彦, 猪瀬崇徳, 宗田真, 宮崎達也, 加藤広行, 桑野博行
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-07-17
• [Presentation] 食道癌手術における低侵襲化・安全性向上への取り組み (2009)
  • Author(s): 中島政信, 宗田真, 田中成岳, 酒井真, 佐野彰彦, 猪瀬崇徳, 加藤広行, 桑野博行
  • Organizer: 第109回日本外科学会定期学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2009-04-02