Diversity of imatinib-resistance clones in gastrointestinal stromal tumors
| Project/Area Number |
21591694
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Niigata University |
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Principal Investigator |
KANDA Tatsuo 新潟大学, 医歯学系, 講師 (80303147)
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| Co-Investigator(Kenkyū-buntansha) |
AJIOKA Yoichi 新潟大学, 医歯学系, 教授 (80222610)
HIROTA Seiichi 兵庫医科大学, 医学部, 教授 (50218856)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | GIST / 遺伝子分析 / イマチニブ / 耐性 / KIT遺伝子 / 消化管間質腫瘍(GIST) / 薬剤耐性腫瘍 / 組織学的多様性 / ダイレクトシークエンス法 / マイクロ・ダイセクション / KIT遺伝子変異 |
|---|
| Research Abstract |
We addressed clonal diversity of imatinib-resistant gastrointestinal stromal tumors(GIST) using histological and genomic approaches. Of 27 imatinib-resistant GIST, 20 tumors(74. 1%) were composed of foci that showed morphologically different appearance. Although PCR samples were retrieved from the 66 tumor foci using a microdissection technique, KIT gene analysis was capable in only 20 foci(30. 3%).
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Report
(4 results)
Research Products
(11 results)
