Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Research Abstract |
We addressed clonal diversity of imatinib-resistant gastrointestinal stromal tumors(GIST) using histological and genomic approaches. Of 27 imatinib-resistant GIST, 20 tumors(74. 1%) were composed of foci that showed morphologically different appearance. Although PCR samples were retrieved from the 66 tumor foci using a microdissection technique, KIT gene analysis was capable in only 20 foci(30. 3%).
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