Diversity of imatinib-resistance clones in gastrointestinal stromal tumors

• Project/Area Number: 21591694
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Niigata University
• Principal Investigator: KANDA Tatsuo 新潟大学, 医歯学系, 講師 (80303147)
• Co-Investigator(Kenkyū-buntansha): AJIOKA Yoichi 新潟大学, 医歯学系, 教授 (80222610) ; HIROTA Seiichi 兵庫医科大学, 医学部, 教授 (50218856)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: GIST / 遺伝子分析 / イマチニブ / 耐性 / KIT遺伝子 / 消化管間質腫瘍(GIST) / 薬剤耐性腫瘍 / 組織学的多様性 / ダイレクトシークエンス法 / マイクロ・ダイセクション / KIT遺伝子変異

Research Abstract

We addressed clonal diversity of imatinib-resistant gastrointestinal stromal tumors(GIST) using histological and genomic approaches. Of 27 imatinib-resistant GIST, 20 tumors(74. 1%) were composed of foci that showed morphologically different appearance. Although PCR samples were retrieved from the 66 tumor foci using a microdissection technique, KIT gene analysis was capable in only 20 foci(30. 3%).

Research Products

• [Journal Article] Secondary resistance to imatinib mesylate 70 months after initiation of therapy in a patient with a metastatic gastric gastrointestinal stromal tumor (2011)
  • Author(s): Tatsuda K, Kanda T, Ishikawa T, Hirota S, 他
  • Journal Title: Clin J Gastroenterol Volume: 4 Pages: 218-22
  • Peer Reviewed
• [Journal Article] 上部消化管疾患の実地臨床: GISTに対する内科治療 (2011)
  • Author(s): 神田達夫, 廣田誠一, 畠山勝義
  • Journal Title: Medical Practice Volume: 28 Pages: 341-346
• [Journal Article] Secondary resistance to imatinib mesylate 70 months after innitiation of therapy in a patient with a metastatic gastric gastrointestinal stromal tumor (2011)
  • Author(s): Tatsuda K, Kanda T, Ishikawa T, Hirota S, 他
  • Journal Title: Clin J Gastroenterol Volume: 4 Issue: 4 Pages: 218-222
  • DOI: 10.1007/s12328-011-0234-9
  • Peer Reviewed
• [Journal Article] 上部消化管疾患の実地臨床:GISTに対する内科治療 (2011)
  • Author(s): 神田達夫、廣田誠一、畠山勝義
  • Journal Title: Medical Practice Volume: 28 Pages: 341-346
• [Journal Article] Surgical resection of gastrointestinal stromal tumor of esophagus following preoperative imatinib treatment : a case report (2010)
  • Author(s): Sato H, Kanda T, Hirota S, Bamba T, Sakamoto K, Kosugi S, Matsuki A, Mashima Y, Ajioka Y, Hatakeyama K
  • Journal Title: Esophagus Volume: 7 Pages: 65-69
  • Peer Reviewed
• [Journal Article] Surgical resection of gastrointestinal stromal tumor of esophagus following preoperative imatinib treatment : a case report. (2010)
  • Author(s): Sato H, Kanda T, et al.
  • Journal Title: Esophagus 7 Pages: 65-69
  • Peer Reviewed
• [Presentation] 切除不能・転移性消化管間質腫瘍に対するイマチニブ治療-二次耐性と増悪腫瘍切除.パネルディスカッション「消化器疾患における分子標的治療」 (2011)
  • Author(s): 神田達夫,石川卓,畠山勝義
  • Organizer: JDDW2011
  • Place of Presentation: 福岡市
  • Year and Date: 2011-10-21
• [Presentation] 切除不能・転移性消化管間質腫瘍に対するイマチニブ治療-二次耐性と増悪腫瘍切除:パネルディスカッション「消化器疾患における分子標的治療」 (2011)
  • Author(s): 神田達夫, 石川卓, 畠山勝義
  • Organizer: JDDW2011
  • Place of Presentation: 福岡県、福岡国際会議場
  • Year and Date: 2011-10-21
• [Presentation] イマチニブ治療増悪後の治療戦略-二次耐性腫瘍切除の位置付け.ワークショップ「GISTの基礎と臨床」 (2010)
  • Author(s): 神田達夫,廣田誠一,畠山勝義
  • Organizer: JDDW2010
  • Place of Presentation: 横浜市
  • Year and Date: 2010-10-14
• [Presentation] イマチニブ治療増悪後の治療戦略一二次耐性腫瘍切除の位置付け (2010)
  • Author(s): 鍾田達夫、廣田誠一、畠山勝義
  • Organizer: JDDW2010
  • Place of Presentation: 横浜市
  • Year and Date: 2010-10-14
• [Presentation] GISTイマチニブ治療における二次耐性腫瘍および奏効残存腫瘍切除の外科治療成績 (2009)
  • Author(s): 神田達夫、番場竹生、廣田誠一, 他
  • Organizer: 第71回日本臨床外科学会総会
  • Place of Presentation: 京都市
  • Year and Date: 2009-11-19