| Project/Area Number |
21591698
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
|
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| Research Institution | Osaka University |
|---|
Principal Investigator |
HIROSHI Miyata 大阪大学, 医学系・研究科, 助教 (80362713)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
DOKI Yuichiro 大阪大学, 医学系・研究科, 教授 (20291445)
TAKIGUCHI Shuji 大阪大学, 医学系・研究科, 助教 (00301268)
YAMASAKI Makoto 大阪大学, 医学系・研究科, 助教 (50444518)
FUJIWARA Yoshiyuki 大阪大学, 医学系・研究科, 講師 (40314330)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 食道癌 / 骨髄由来細胞 / 化学療法 / 上皮間葉転換 / 腫瘍間質 / 微小環境 / マクロファージ |
|---|
| Research Abstract |
Immunohistochemical analysis using surgical specimens of esophageal cancer after chemotherapy and mouse model analysis showed that bone. marrow derived cells, especially macrophages, migrated to tumor stroma after cisplatin-based chemotherapy. Infiltration of CD11b(+) cells, c-kit(+) cells and M2 macrophage to tumor stroma correlated inversely with response to chemotherapy. Taken together, these results suggest that recruitment of bone-marrow derived cells is associated with chemoresistance in esophageal cancer.
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