New combinatorial approach to peritoneal dissemination of scirrhous gastric carcinoma based REIC/Dkk-3 gene therapy
Project/Area Number |
21591699
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Okayama University |
Principal Investigator |
KATAOKA Ken 岡山大学, 大学院・医歯薬学総合研究科, 講師 (10293317)
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Co-Investigator(Kenkyū-buntansha) |
SAKAGUCHI Masakiyo 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70379840)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | REIC/Dkk-3 / Gene Therapy / Scirrhous Gastric Carcinoma / Peritoneal Dissemination / REIC / Dkk-3 |
Research Abstract |
A single intraperitoneal injection of REIC/Dkk-3 adenovirus suppressed tumor dissemination and disease progression of scirrhous gastric carcinoma(SGC) in the mouse model. Immunomodulation by Ad-REIC led to recruitment of natural killer cells inside tumor nodules. We conclude that REIC/Dkk-3 gene therapy may be a potential tool in combinatorial approaches to achieve curative effects in SGC. We also demonstrated that PINK1, a key molecule for the mitochondrial protection system, was a new target molecule to sensitize resistant cancer cells to REIC/Dkk-3 gene therapy.
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Report
(4 results)
Research Products
(55 results)
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[Journal Article] Tumor suppressor REIC/Dkk-3 interacts with the dynein light chain, Tctex-12011
Author(s)
Ochiai K, Watanabe M, Ueki H, Huang P, Fujii Y, Nasu Y, Noguchi H, Hirata T, Sakaguchi M, Huh NH, Kashiwakura Y, Kaku H, Kumon H
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Journal Title
Biochem Biophys Res Commun
Volume: 412
Pages: 391-395
Related Report
Peer Reviewed
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[Journal Article] TIRAP, an adaptor protein for TLR2/4, transduces a signal from RAGE phosphorylated upon ligand binding2011
Author(s)
Sakaguchi M, Murata H, Yamamoto KI, Ono T, Sakaguchi Y, Motoyama A, Hibino T, Kataoka K, Huh NH
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Intraperitoneal administration of an adenovirus vector carrying REIC/Dkk-3 gene suppresses peritoneal dissemination of scirrhous gastric carcinoma2011
Author(s)
Than SS, Kataoka K, Sakaguchi M, Murata H, Abarzua F, Taketa C, Du G, Yashiro M, Yanagihara K, Nasu Y, Kumon H, Huh NH
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Journal Title
Oncol Rep
Volume: 25
Pages: 989-995
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Peer Reviewed
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[Journal Article] Overexpression of REIC/Dkk-3 in normal fibroblasts suppresses tumor growth via induction of IL-72009
Author(s)
Sakaguchi M, Kataoka K, Abarzua F, Tanimoto R, Watanabe M, Murata H, Than SS, Kurose K, Kashiwakura Y, Nasu Y, Kumon H, Huh NH
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Journal Title
J Biol Chem
Volume: 284
Pages: 14236-14244
Related Report
Peer Reviewed
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[Journal Article] REIC/Dkk-3 stable transfection reduces the malignant phenotype of mouse prostate cancer RM9 cells2009
Author(s)
Chen J, Watanabe M, Huang P, Sakaguchi M, Ochiai K, Nasu Y, Ouchida M, Huh NH, Shimizu K, Kashiwakura Y, Kaku H, Kumon H
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Journal Title
Int JMol Med
Volume: 24
Pages: 89-794
Related Report
Peer Reviewed
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[Presentation] TIRAP, an adaptor protein for TLR-2/-4, transduces a signal from RAGE phosphorylated upon ligand binding(多機能受容体RAGEの下流信号伝達機構の解明)2010
Author(s)
Sakaguchi M, Murata H, Yamamoto KI, Ono T, Sakaguchi Y, Motoyama A, Hibino T, Kataoka K, Huh NH
Organizer
第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
Place of Presentation
神戸
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