| Project/Area Number |
21591700
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
|
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| Research Institution | Kawasaki Medical School (2010-2011)
Okayama University (2009) |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
NAOMOTO Yooshio 川崎医科大学, 医学部, 教授 (00237190)
FUKAZAWA Takuya 川崎医科大学, 医学部, 講師 (20379845)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | HSP90 / 核内移行 / ヘパラナーゼ / AUY922 / Akt |
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| Research Abstract |
Heat shock protein 90(HSP90), a molecular chaperone, has provoked great interest as a promising molecular target for cancer treatment, due to its involvement in regulating the conformation, stability and functions of key oncogenic proteins. The aim of our study was to evaluate the antitumor effects of a novel HSP90 inhibitor, AUY922. AUY922 potently inhibited the proliferation of cancer cells. We demonstrated that the novel HSP90 inhibitor AUY922 exhibits a potent antitumor effect in cancer cells, providing a novel therapeutic alternative for cancer treatment.
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