Cigarette smoking, alcohol drinking, oxidative stress and tumor suppressor gene abnormality in the development of esophageal cancer
Project/Area Number |
21591701
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | 独立行政法人国立病院機構九州がんセンター臨床研究センター (2011) Kyushu University (2009-2010) |
Principal Investigator |
MORITA Masaru 独立行政法人国立病院機構九州がんセンター臨床研究センター, 統括診療部, 消化器外科医長 (30294937)
|
Co-Investigator(Kenkyū-buntansha) |
KAKEJI Yoshihiro 九州大学, 医学(系)研究科(研究院), 准教授 (80284488)
EMI Yasunori 九州大学, 大学病院, 特任准教授 (40516019)
YOSHINAGA Keishi 九州大学, 大学病院, 特任助教 (90507790)
OHGA Takefumi 九州大学, 大学病院, 助教 (60335958)
EGASHIRA Akinori 九州大学, 大学病院, 特任助教 (00419524)
SAEKI Hiroshi 九州大学, 大学病院, 助教 (80325448)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 食道癌 / 喫煙 / 飲酒 / 発癌 / 癌抑制遺伝子 / p53 / 酸化ストレス / 酸化的DNA損 / 癌抑制遺 / 酸化 |
Research Abstract |
Oxidative DNA damage, which partially induced by smoking, as well as disturbance of repair system, must be closely related to esophageal carcinogenesis and it's progression. The p53 gene mutation was frequently observed in the esophageal cancer and predominance of transversion mutations, which indicate possible importance of the benzo[a] pyrene metabolite and oxidative DNA damage, were also recognized. Furthermore, LOH without copy number change(copy-neutral LOH) at the p53 locus might be the major mechanism for inactivation of the intact allele in esophageal squamous cell carcinogenesis associated with p53 mutation.
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Report
(4 results)
Research Products
(138 results)
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[Journal Article] Lymph node metastasis from cancer of the esophagogastric junction, and determination of the appropriate nodal dissection2012
Author(s)
Kakeji Y, Yamamoto M, Ito S, Sugiyama M, Egashira A, Saeki H, Morita M, Sakaguchi Y, Toh Y, Maehara Y
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Journal Title
Surg Today
Volume: 42
Issue: 4
Pages: 351-358
DOI
NAID
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Peer Reviewed
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[Journal Article] ATR-Chk1 signaling pathway and homologous recombinational repair protect cells from 5-fluorouracil cytotoxicity2012
Author(s)
Fujinaka Y, Matsuoka K, Iimori M, Tuul M, Sakasai R, Yoshinaga K, Saeki H, Morita M, Kakeji Y, Gillespie DA, Yamamoto K, Takata M, Kitao H, Maehara Y
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Journal Title
DNA Repair (Amst)
Volume: 11
Pages: 247-258
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Peer Reviewed
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[Journal Article] Biological mechanism and clinical effect of protein-bound polysaccharide K (KRESTIN([○!R])) : review of development and future perspectives2012
Author(s)
Maehara Y, Tsujitani S, Saeki H, Oki E, Yoshinaga K, Emi Y, Morita M, Kohnoe S, Kakeji Y, Yano T, Baba H
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Journal Title
Surg Today
Volume: 42
Issue: 1
Pages: 8-28
DOI
NAID
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Peer Reviewed
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[Journal Article] Antagonism of VEGF by genetically engineered dendritic cells is essential to induce antitumor immunity against malignant ascites2011
Author(s)
Sugiyama M, Kakeji Y, Tsujitani S, Harada Y, Onimaru M, Yoshida K, Tanaka S, Emi Y, Morita M, Morodomi Y, Hasegawa M, Maehara Y, Yonemitsu Y
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Journal Title
Mol Cancer Ther
Volume: 10
Issue: 3
Pages: 540-549
DOI
NAID
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Peer Reviewed
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[Journal Article] In-hospital mortality after a surgical resection for esophageal cancer : Analysis of the associated factors and historical changes2011
Author(s)
Morita M, Nakanoko T, Fujinaka Y, Kubo N, Yamashita N, Yoshinaga K, Saeki, H, Emi Y, Kakeji Y, Shirabe, K, Maehara, Y.
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Journal Title
Ann Surg Oncol
Volume: (Published on line in press)
Related Report
Peer Reviewed
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[Journal Article] Antagonism of VEGF by genetically engineered dendritic cells is essential to induce antitumor immunity against malignant ascitis.2011
Author(s)
Sugiyama M, Kakeji Y, Harada Y, Onimaru M, Yoshida K, Tanaka S, Emi Y, Morita M, Morodomi Y, Hasegawa Y, Maehara Y, Yonemitsu Y
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Journal Title
Mol Cancer Ther
Volume: (Published on line in press)
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Peer Reviewed
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[Journal Article] Colorectal cancer screening with odour material bycanine scent detection2011
Author(s)
Sonoda H, Kohnoe S, Yamazato T, Satoh Y, Morizono G, Shikata K, Morita M, Watanabe A, Morita M, Kakeji Y, Inoue F, Maehara Y
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Journal Title
Gut
Volume: (Published on line in press)
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Peer Reviewed
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[Journal Article] Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus : epidemiology, clinical findings, and prevention2010
Author(s)
Morita M, Kumashiro R, Kubo N, Nakashima Y, Yoshida R, Yoshinaga K, Saeki H, Emi Y, Kakeji Y, Sakaguchi Y, Toh Y, Maehara Y
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Journal Title
Int J Clin Oncol
Volume: 15
Pages: 126-134
NAID
Related Report
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[Journal Article] Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus : molecular mechanisms of carcinogenesis.2010
Author(s)
Toh Y, Oki E, Ohgaki K, Sakamoto Y, Ito S, Egashira A, Saeki H, Kakeji Y, Morita M, Sakaguchi Y, Okamura T, Maehara Y
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Journal Title
Int J Clin Oncol
Volume: 15
Pages: 135-144
NAID
Related Report
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[Journal Article] High expression of BUBR1 is one of the factors for inducing DNA aneuploidy and progression in gastric cancer.2010
Author(s)
Ando K, Kakeji Y, Kitao H, Iimori M, Zhao Y, Yoshida R, Oki E, Yoshinaga K, Matumoto T, Morita M, Sakaguchi Y, Maehara Y
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Journal Title
Cancer Sci
Volume: 101
Pages: 639-645
NAID
Related Report
Peer Reviewed
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[Journal Article] Impact of perioperative peripheral blood values on postoperative complications after esophageal surgery.2010
Author(s)
Saeki H, Masuda T, Okada S, Ando K, Sugiyama M, Yoshinaga K, Endo K, Sadanaga N, Emi Y, Kakeji Y, Morita M, Yamashita N, Maehara Y
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Journal Title
Surgery Today
Volume: 40
Pages: 626-631
NAID
Related Report
Peer Reviewed
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[Journal Article] Repair using the pectoralis major muscle flap for anastomotic leakage after esophageal reconstruction via the subcutaneous route2010
Author(s)
Morita M., Ikeda K., Sugiyama M., Saeki H., Egashira A., Yoshinaga K., Oki E., Sadanaga N., Kakeji Y., Fukushima J., Maehara Y.
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Journal Title
Surgery 147-2
Pages: 212-218
Related Report
Peer Reviewed
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[Journal Article] Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus : epidemiology, clinical findings, and prevention2010
Author(s)
Morita M, Kumashiro R, Kubo N, Nakashima Y, Yoshida R, Yoshinaga K, Saeki H, Emi Y, Kakeji Y, Sakaguchi Y, Toh Y, Maehara Y
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Journal Title
Int J Clin Oncol (Published on line in press)
NAID
Related Report
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[Journal Article] Alcohol drinking, cigarette smoking, and the development of squamous cell carcinoma of the esophagus : molecular mechanisms of carcinogenesis2010
Author(s)
Toh Y, Oki E, Ohgaki K, Sakamoto Y, Ito S, Egashira A, Saeki H, Kakeji Y, Morita M, Sakaguchi Y, Okamura T, Maehara Y
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Journal Title
Int J Clin Oncol (Published on line in press)
NAID
Related Report
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[Journal Article] Postoperative management using intensive patient-controlled epidural analgesia and early rehabilitation after an esophagectomy2009
Author(s)
Saeki H., Ishimura H., Higashi H., Kitagawa D., Tanaka J., Maruyama R., Katoh H., Shimazoe H., Yamauchi K., Ayabe H., Kakeji Y., Morita M., Maehara Y.
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Journal Title
Surgery Today 39-6
Pages: 476-480
NAID
Related Report
Peer Reviewed
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[Journal Article]2009
Author(s)
森田勝, 掛地吉弘, 前原喜彦
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Journal Title
消化器病学の進歩―減点から未来への情報発信 第94回日本消化器病学会総会記念会誌 III複合領域(日本消化器病学会・医学書院)
Pages: 85-89
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[Presentation] Clinical significance of definitive chemoradiotherapy and salvage surgery for squamous cell carcinoma of the esophagus2010
Author(s)
Morita M, Yoshida R, Yoshinaga K, Egashira A, Saeki H, Ohga T, Kakeji Y, Emi Y, Shioyama Y, Maehara Y
Organizer
2010 Annual Meeting of the American Society of Clinical Oncology
Place of Presentation
Chicago, USA
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[Presentation] The oxidative DNA stress and expression of oxdative DNA damage repair enzyme in esophageal cancer.2010
Author(s)
Kubo N, Morita M, Kumashiro R, Nakanishi R, Hisamatsu Y, Nakanoko T, Fujinaka Y, Kitao H, Sonoda H, Egashira A, Ohga T, Kakeji Y, Maehara Y
Organizer
12th World Congress of the International Society for Diseases of the Esophagus
Place of Presentation
Kagoshima, Japan
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[Presentation] 食道癌 Salvage 手術の成績と根治性・安全性を目指す工夫2009
Author(s)
森田勝, 神代竜一, 中西良太, 久松雄一, 久保信英, 中ノ子智徳, 藤中良彦, 杉山雅彦, 吉田倫太郎, 吉永敬士, 佐伯浩司, 江見泰徳, 掛地吉弘, 前原喜彦
Organizer
第62回日本胸部外科学会定期学術集会
Place of Presentation
横浜
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[Presentation] 食道癌に対する術前および根治的化学放射線療法の位置づけ2009
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森田勝, 神代竜一, 中西良太, 久松雄一, 久保信英, 中ノ子智徳, 藤中良彦, 杉山雅彦, 吉田倫太郎, 吉永敬士, 佐伯浩司, 江見泰徳, 掛地吉弘, 塩山善之, 前原喜彦
Organizer
第47回日本癌治療学会学術集会
Place of Presentation
横浜
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[Presentation] Barrett 食道癌の治療 Barrett 食道癌の臨床病理学的特徴と治療戦略2009
Author(s)
森田勝, 神代竜一, 中西良太, 久松雄一, 中ノ子智徳, 久保信英, 藤中良彦, 杉山雅彦, 美馬浩介, 吉田倫太郎, 吉永敬士, 佐伯浩司, 江見泰徳, 掛地吉弘, 前原喜彦
Organizer
第71回日本臨床外科学会総会
Place of Presentation
京都
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[Presentation] 食道扁平上皮癌におけるポドプラニン発現のがん浸潤と予後に及ぼす影響2009
Author(s)
中島雄一郎, 吉永敬士, 北尾洋之, 杉山雅彦, 岡田敏子, 吉田倫太郎, 佐伯浩司, 江見泰徳, 森田勝, 掛地吉弘, 平橋美奈子, 前原喜彦
Organizer
第68回日本癌学会学術総会
Place of Presentation
横浜
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