| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We isolated circulating tumor cells(CTCs) using CellSearch^<TM> in five cases of gastric cancer patients with disseminated carcinomatosis of bone marrow. Then, we could identify several candidate genes involved in pathogenesis of this disease, based on the result of gene expression profiling of collected CTCs. As CTCs in two patients remarkably increased and most of CTCs highly expressed HER2, we used' trastuzumab', the monoclonal antibody against HER2, combined with the chemotherapy, against these two patients. They had remission of DIC and long-term survival. Moreover, we could establish mouse xenograft model using CTCs obtained from two gastric cancer patients with disseminated carcinomatosis of bone marrow.
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