Effect of DNA methylation on the regulation of microRNA in squamous cell carcinoma of the esophagus

• Project/Area Number: 21591704
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kumamoto University
• Principal Investigator: WATANABE Masayuki 熊本大学, 大学院・生命科学研究部, 講師 (80254639)
• Co-Investigator(Kenkyū-buntansha): BABA Hideo 熊本大学, 大学院・生命科学研究部, 教授 (20240905) ; KAMOHARA Hidenobu 熊本大学, 大学院・生命科学研究部, 准教授 (90398222)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: DNAメチル化異常 / SYBR green法 / microRNA / ホルマリン固定標本 / 化学療法感受性 / 食道癌 / 食道扁平上皮癌 / micoRNA / pyrosequence / LINE-1 / FBXW7 / ZEB-2

Research Abstract

We clarified that global hypomethylation was observed in squamous cell carcinoma of the esophagus(ESCC) and the hypomethylation of LINE-1 was a significant indicator for poor prognosis in patients with ESCC. We also identified that overexpression of microRNA(miR)-29c was a prognostic factor of patients with ESCC and miR-223 regulated FBXW7 in ESCC. We examined miR-21 expression in the serum and clarified that the serum miR-21 levels of ESCC patients was significantly higher than those of healthy controls and the serum miR-21 expression could be a marker for treatment effect for ESCC.

Research Products

• [Journal Article] Pyrosequencing Assay to Measure LINE-1 Methylation Level in Esophageal Squamous Cell Carcinoma (2012)
  • Author(s): Iwagami S, Baba Y, Watanabe M, Shigaki H, Miyake K, Ida S, Nagai Y, Takatsugu I, Iwatsuki M, Sakamoto Y, Miyamoto Y, Baba H
  • Journal Title: Annals of Surgical Oncology Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] MicroRNA-200b regulates cell proliferation, invasion and migration by directly targeting ZEB2 in gastric carcinoma (2012)
  • Author(s): Kurashige J, Kamohara H, Watanabe M, Hiyoshi Y, Iwatsuki M, Tanaka Y, Kinoshita K, Saito S, Baba Y, Baba H
  • Journal Title: Ann Surg Oncol Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Serum microRNA-21 is a novel biomarker in patients with esophageal squamous cell carcinoma (2012)
  • Author(s): Kurashige J, Kamohara H, Watanabe M, Tanaka Y, Kinoshita K, Saito S, Hiyoshi Y, Iwatsuki M, Baba Y, Baba H
  • Journal Title: J Surg Oncol Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Minimally invasive esophagectomy for esophageal cancer (2012)
  • Author(s): Watanabe M, Baba Y, Nagai Y, Baba H
  • Journal Title: Surg Today Volume: (印刷中)
• [Journal Article] Line-1 hypomethylation is associated with a poor prognosis among patients with curatively resected esophageal squamous cell carcinoma (2012)
  • Author(s): Iwagami S, Baba Y, Watanabe M, Shigaki H, Miyake K, Ishimoto T, Iwatsuki M, Sakamaki K, Ohashi Y, Baba H
  • Journal Title: Annals of Surgery Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Salvage lymphadenectomy for cervical lympf node recurrence after esophagectomy for squamous cell carcinoma of the thoracic esophagus (2012)
  • Author(s): Watanabe M, Nishida K, Kimura Y, Miyazaki M, Baba H
  • Journal Title: Dis Esophagus Volume: 25巻 Pages: 62-6
  • Peer Reviewed
• [Journal Article] Overexpression of microRNA-223 regulates the ubiquitin ligase FBXW7 in esophageal squamous cell carcinoma (2012)
  • Author(s): Kurashige J, Watanabe M, Iwatsuki M, Kinoshita K, Saito S, Hiyoshi Y, Kamohara H, Baba H, Mimori K
  • Journal Title: Br J Cancer Volume: 106巻 Pages: 182-188
  • Peer Reviewed
• [Journal Article] Minimally invasive esophagectomy for esophageal cancer ; an updated review (2012)
  • Author(s): Watanabe M, Baba Y, Nagai Y, Baba H
  • Journal Title: Sure Today Volume: (in press)
  • NAID: 10031167996
  • Peer Reviewed
• [Journal Article] Induction chemotherapy with docetaxel/cisplatin/5-fluorouracil for patients with node-positive esophageal cancer (2011)
  • Author(s): Watanabe M, Nagai Y, Kinoshita K, Saito S, Kurashige J, Karashima R, Hirashima K, Sato N, Imamura Y, Hiyoshi Y, Baba Y, Iwagami S, Miyamoto Y, Iwatsuki M, Hayashi N, Baba H
  • Journal Title: Digestion Volume: 83巻 Pages: 146-152
  • Peer Reviewed
• [Journal Article] Induction chemotherapy with docetaxel/cisplatin/5-fuorouracil for patients with node-positive esophageal cancer (2011)
  • Author(s): Watanabe M, Nagai Y, Kinoshita K, Saito S, Kurashige J, Karashima R, Hirashima K, Sato N, Imamura Y, Hiyoshi Y, Baba Y, Iwagami S, Miyamoto Y, Iwatsuki M, Hayashi N, Baba H
  • Journal Title: Digestion Volume: 83 Issue: 3 Pages: 146-152
  • DOI: 10.1159/000321797
  • Peer Reviewed
• [Journal Article] Clinical significance of wnt-induced secreted protein-1 (wisp-1/ccn4) inesophageal squamous cell carcinoma. (2011)
  • Author(s): Nagai Y, Watanabe M, Ishikawa S, Iwastuki M, Baba Y, Imamura Y, Hayashi N, Baba H
  • Journal Title: Anticancer Res Volume: (in press)
  • Peer Reviewed
• [Journal Article] Phosphorylated mTOR expression is associated with poor prognosis for patients with esophageal squamous cell carcinoma. (2010)
  • Author(s): Hirashima K, Baba Y, Watanabe M, Karashima R, Sato N, Imamura Y, Hiyoshi Y, Nagai Y, Hayashi N, Iyama K, Baba H
  • Journal Title: Ann Surg Oncol Volume: 17 Pages: 2486-2493
  • Peer Reviewed
• [Journal Article] Extensive lymphatic spread of cancer cells in patients with thoracic esophageal squamous cell carcinoma : Detection of CEA-mRNA in the 3-field lymph nodes. (2010)
  • Author(s): Imamura Y, Hayashi N, Sato N, Kinoshita K, Kurashige J, Saito S, Hirashima K, Karashima R, Hiyoshi Y, Nagai Y, Watanabe M, Baba H
  • Journal Title: J Surg Oncol Volume: 102 Pages: 509-515
  • Peer Reviewed
• [Journal Article] Micro RNA expression profiling of exfoliated colonocytes isolated from feces for colorectal cancer screening. (2010)
  • Author(s): Koga Y, Yasunaga M, Takahashi A, Kuroda J, Moriya Y, Akasu Y, Fujita S, Yamamoto S, Baba H, Matsumura Y
  • Journal Title: Cancer Prev Res Volume: 3 Pages: 1435-1442
  • Peer Reviewed
• [Journal Article] Induction chemotherapy with docetaxel/cisplatin/5-fluorouracil for patients with node-positive esophageal cancer. (2010)
  • Author(s): Watanabe M, Nagai Y, Kinoshita K, Saito S, Kurashige J, Karashima R, Hirashima K, Sato N, Imamura Y, Hiyoshi Y, Baba Y, Iwagami S, Miyamoto Y, Iwatsuki M, Hayashi N, Baba H
  • Journal Title: Digestion Volume: 83 Pages: 146-152
  • Peer Reviewed
• [Journal Article] MicroRNA-21 regulates proliferation and invasion in esophageal squamous cell carcinoma (2009)
  • Author(s): Hiyoshi Y
  • Journal Title: Clin Cancer Res15 Volume: 6巻 Pages: 1915-1922
  • Peer Reviewed
• [Journal Article] p12cdk-2AP1 is associated with tumor progression and poor prognosis in esophageal squamous cell carsinoma. (2009)
  • Author(s): Hiyoshi Y
  • Journal Title: Oncol Rep Volume: 22巻 Pages: 35-39
  • Peer Reviewed
• [Journal Article] MicroRNA-21 regulates proliferation and invasion in esophageal squamous cell carcinoma (2009)
  • Author(s): Hiyoshi Y
  • Journal Title: Clin Cancer Res 15 6 Pages: 1915-1922
  • Peer Reviewed
• [Journal Article] p12cdk-2AP1 is associated with tumor progression and poor prognosis in esophageal squamous cell carsinoma (2009)
  • Author(s): Hiyoshi Y
  • Journal Title: Oncol Rep 22 Pages: 35-39
  • Peer Reviewed
• [Presentation] 食道扁平上皮癌におけるLINE-1メチル化レベルの網羅的解析-Pyrosequencing technologyを用いて- (2012)
  • Author(s): 馬場祥史
  • Organizer: 第8回日本消化管学会総会学術集会
  • Place of Presentation: 宮城県仙台国際センター
  • Year and Date: 2012-02-10
• [Presentation] 食道扁平上皮癌におけるLINE-1メチル化レベルの網羅的解析-Pyrosequencing technologyを用いて- (2012)
  • Author(s): 馬場祥史
  • Organizer: 第8回日本消化管学会総会学術集会
  • Place of Presentation: 仙台国際センター
  • Year and Date: 2012-02-10
• [Presentation] 胃癌におけるmicroRNA-200familyの発現と臨床病理学的検討 (2012)
  • Author(s): 蔵重淳二
  • Organizer: 第84回日本胃癌学会総
  • Place of Presentation: 大阪府グランキューブ大阪
  • Year and Date: 2012-02-09
• [Presentation] 胃癌におけるmicroRNA-200familyの発現と臨床病理学的検討 (2012)
  • Author(s): 蔵重淳二
  • Organizer: 第84回日本胃癌学会総会
  • Place of Presentation: グランキューブ大阪
  • Year and Date: 2012-02-09
• [Presentation] The association between smoking and LINE-1 hypomethylation(global DNA hypomethylation) in normal esophageal epithelium of patients with esophageal squamous cell carcinoma. (2012)
  • Author(s): Iwagami S
  • Organizer: ASCO 2012 Gastrointestinal Cancers Symposium
  • Place of Presentation: Francisco USA
  • Year and Date: 2012-01-19
• [Presentation] Prognostic significance of LINE-1 methylation level in esophageal squamous cell carcinoma (2012)
  • Author(s): Baba Y
  • Organizer: ASCO 2012 Gastrointestinal Cancers Symposium
  • Place of Presentation: San Francisco USA
  • Year and Date: 2012-01-19
• [Presentation] The association between smoking and LINE-1 hypomethylation (global DNA hypomethylation) in normal esophageal epithelium of patients with esophageal squamous cell carcinoma (2012)
  • Author(s): Iwagami S
  • Organizer: ASCO 2012 Gastrointestinal Cancers Symposium
  • Place of Presentation: San Francisco USA
  • Year and Date: 2012-01-19
• [Presentation] 食道癌患者の血清中のエキソームが内包するmicroRNA発現の検討 (2011)
  • Author(s): 田中洋平
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 愛知県名古屋国際会議場
  • Year and Date: 2011-10-05
• [Presentation] 食道癌患者の血清中のエキソームが内包するmicroRNA発現の検討 (2011)
  • Author(s): 田中洋平
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-05
• [Presentation] 胃癌におけるmicroRNA-200 bによる浸潤転移機構の制御 (2011)
  • Author(s): 蔵重淳二
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 愛知県名古屋国際会議場
  • Year and Date: 2011-10-04
• [Presentation] 食道癌の発育進展におけるmTORの関与とmiRNAによる制御 (2011)
  • Author(s): 木下浩一
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 愛知県名古屋国際会議場
  • Year and Date: 2011-10-04
• [Presentation] 胃癌におけるmicroRNA-200bによる浸潤転移機構の制御 (2011)
  • Author(s): 蔵重淳二
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-04
• [Presentation] 食道癌の発育進展におけるmTORの関与とmiRNAによる制御 (2011)
  • Author(s): 木下浩一
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2011-10-04
• [Presentation] The Identification of novel micro RNAs and Genes in bone marrow regulating gastric cancer metastasis (2011)
  • Author(s): Iwatsuki M
  • Organizer: The 8th International Symposium on Minimal Residual Cancer
  • Place of Presentation: グランキューブ大阪
  • Year and Date: 2011-09-22
• [Presentation] MicroRNA-200b regulates Epithelial Mesenchymal Transition by targeting ZEB2 in Gastric Cancer (2011)
  • Author(s): Kurashige J
  • Organizer: The 8th International Symposium on Minimal Residual Cancer
  • Place of Presentation: グランキューブ大阪
  • Year and Date: 2011-09-22
• [Presentation] MicroRNA-200b regulates Epithelial Mesenchymal Transition by targeting ZEB2 in Gastric Cancer (2011)
  • Author(s): Kurashige J
  • Organizer: the 8th International Symposium on Minimal Residual Cancer
  • Place of Presentation: グランキューブ大阪
  • Year and Date: 2011-09-22
• [Presentation] The Identification of novel micro RNAs and Genes in bone marrow regulating gastric cancer metastasis (2011)
  • Author(s): Iwatsuki M
  • Organizer: the 8th International Symposium on Minimal Residual Cancer
  • Place of Presentation: グランキューブ大阪
  • Year and Date: 2011-09-22
• [Presentation] 胃癌におけるmicroRNA-200 bによる浸潤転移機構の制御 (2011)
  • Author(s): 蔵重淳二
  • Organizer: コングレスセンター・オークラアクトシティホテル浜松
  • Place of Presentation: アクトシティ浜松
  • Year and Date: 2011-07-01
• [Presentation] 胃癌におけるmicroRNA-200bによる浸潤転移機構の制御 (2011)
  • Author(s): 蔵重淳二
  • Organizer: 第20回日本がん転移学会学術集会・総会
  • Place of Presentation: アクトシティ浜松コングレスセンター・オークラアクトシティホテル浜松
  • Year and Date: 2011-07-01
• [Presentation] 食道癌予後因子としてのmiR-29cの発現の意義/MicroRNA-29c expression as a new prognostic marker as esophageal cancer (2011)
  • Author(s): 木下浩一
  • Organizer: 第111回日本外科学会定期学術集会
  • Place of Presentation: 誌上発表
  • Year and Date: 2011-05-26
• [Presentation] 食道癌患者血清から抽出したエキソソーム内のmicroRNAの発現解析/Expression profiling of micro-RNAs in exosomes extracted from human esophageal cancer serum (2011)
  • Author(s): 田中洋平
  • Organizer: 第111回日本外科学会定期学術集会
  • Place of Presentation: 誌上発表
  • Year and Date: 2011-05-26
• [Presentation] 胃癌におけるmicroRNA-200bによる癌浸潤転移の制御機構/The miR-200b regulates epithelial to mesenchymal transition in gastric cancer (2011)
  • Author(s): 蔵重淳二
  • Organizer: 第111回日本外科学会定期学術集会
  • Place of Presentation: 誌上発表
  • Year and Date: 2011-05-26
• [Presentation] 胃癌におけるmicroRNA-200bによる癌浸潤転移の制御機構/The miR-200b regulates epithelial to mesenchymal transition in gastric cancer (2011)
  • Author(s): 蔵重淳二
  • Organizer: 第111回日本外科学会定期学術集会
  • Place of Presentation: (紙上発表)(震災のため)
  • Year and Date: 2011-05-26
• [Presentation] 食道癌患者血清から抽出したエキソソーム内のmicroRNAの発現解析/Expression profiling of micro-RNAs in exosomes extracted from human esophageal cancer serum (2011)
  • Author(s): 田中洋平
  • Organizer: 第111回日本外科学会定期学術集会
  • Place of Presentation: (紙上発表)(震災のため)
  • Year and Date: 2011-05-26
• [Presentation] 食道癌予後因子としてのmiR-29cの発現の意義/MicroRNA-29c expression as a new prognostic marker as esophageal cancer (2011)
  • Author(s): 木下浩一
  • Organizer: 第111回日本外科学会定期学術集会
  • Place of Presentation: (紙上発表)(震災のため)
  • Year and Date: 2011-05-26
• [Presentation] Line-1 methylation level(global DNA methylation level) in gastric cancer (2011)
  • Author(s): Baba Y
  • Organizer: 9th International Gastric Cancer Congress
  • Place of Presentation: Seoul Korea
  • Year and Date: 2011-04-23
• [Presentation] Line-1 methylation level (global DNA methylation level) in gastric cancer (2011)
  • Author(s): Baba Y
  • Organizer: 9th International Gastric Cancer Congress
  • Place of Presentation: Seoul Korea
  • Year and Date: 2011-04-23
• [Presentation] MIcroRNA-200B regulates epithelial to mesenchymal transition in gastric carcinoma (2011)
  • Author(s): Kurashige J
  • Organizer: 9th International Gastric Cancer Congress
  • Place of Presentation: Seoul Korea
  • Year and Date: 2011-04-22
• [Presentation] MicroRNA-29c expression as a new prognostic marker for esophageal squamous cell carcinoma (2011)
  • Author(s): Kinoshita K
  • Organizer: AACR102nd Annual Meeting2011
  • Place of Presentation: Orlando USA
  • Year and Date: 2011-04-02
• [Presentation] Serum microRNA-21 is a novel biomarker in patients with esophageal squamous cell carcinoma (2011)
  • Author(s): Kurashige J
  • Organizer: AACR102nd Annual Meeting 2011
  • Place of Presentation: Orlando USA
  • Year and Date: 2011-04-02
• [Presentation] MicroRNA-29c expression as a new prognostic marker for esophageal squamous cell carcinoma (2011)
  • Author(s): Kinoshita K
  • Organizer: AACR102nd Annual Meeting 2011
  • Place of Presentation: Orlando USA
  • Year and Date: 2011-04-02
• [Presentation] Serum microRNA-21 is a novel biomarker in patients with esophageal squamous cell carcinoma (2011)
  • Author(s): Kurashige J
  • Organizer: AACR102nd Annual Meeting 2011
  • Place of Presentation: Orange Country Convention Center
  • Year and Date: 2011-04-02
• [Presentation] MicroRNA-29c expression as a new prognostic marker for esophageal squamous cell carcinoma (2011)
  • Author(s): Kinoshita K
  • Organizer: AACR102nd Annual Meeting 2011
  • Place of Presentation: Orange Country Convention Center
  • Year and Date: 2011-04-02
• [Presentation] 腫瘍マーカーとしてのmicroRNAの可能性 (2010)
  • Author(s): 蔵重淳二
  • Organizer: JDDW2010第8回日本消化器外科学会大会
  • Place of Presentation: 横浜市パシフィコ横浜
  • Year and Date: 2010-10-15
• [Presentation] 腫瘍マーカーとしてのmicroRNAの可能性 (2010)
  • Author(s): 蔵重淳二
  • Organizer: JDDW2010 第8回日本消化器外科学会大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2010-10-15
• [Presentation] MicroRNA-21 and-26a are novel markers to predict the sensitivity of chemotherapy to esophageal squamous cell carcinoma (2010)
  • Author(s): Kurashige J
  • Organizer: 12th World congress of the international society for diseases(第12回国際食道学会)
  • Place of Presentation: 鹿児島市城山観光ホテル
  • Year and Date: 2010-09-15
• [Presentation] MicroRNA-21 and -26a are novel markers to predict the sensitivity of chemotherapy to esophageal squamous cell carcinoma (2010)
  • Author(s): Kurashige J
  • Organizer: 12th World congress of the international society for diseases(第12回国際食道学会)
  • Place of Presentation: 鹿児島城山観光ホテル
  • Year and Date: 2010-09-05
• [Presentation] microRNAによる食道癌抗癌剤効果予測の可能性 (2010)
  • Author(s): 蔵重淳二
  • Organizer: 第65回日本消化器外科学会総会
  • Place of Presentation: 福岡県海峡メッセ下関
  • Year and Date: 2010-07-14
• [Presentation] 食道癌におけるmicroRNA発現パターンと予後との相関 (2010)
  • Author(s): 木下浩一
  • Organizer: 第65回日本消化器外科学会総会
  • Place of Presentation: 福岡県海峡メッセ下関
  • Year and Date: 2010-07-14
• [Presentation] 食道癌におけるmicroRNA発現パターンと予後との相関 (2010)
  • Author(s): 木下浩一
  • Organizer: 第65回日本消化器外科学会総会
  • Place of Presentation: 下関グランドホテル
  • Year and Date: 2010-07-14
• [Presentation] microRNAによる食道癌抗癌剤効果予測の可能性 (2010)
  • Author(s): 蔵重淳二
  • Organizer: 第65回日本消化器外科学会総会
  • Place of Presentation: 下関グランドホテル
  • Year and Date: 2010-07-14
• [Presentation] 食道扁平上皮癌におけるEZH2の発現意義とmicroRNA-101によるEZH2の発現制御 (2010)
  • Author(s): 日吉幸晴
  • Organizer: 第110回日本外科学会
  • Place of Presentation: 愛知県名古屋国際会議場
  • Year and Date: 2010-04-10
• [Presentation] 食道扁平上皮癌におけるEZH2の発現意義とmicroRNA-101によるEZH2の発現制御 (2010)
  • Author(s): 日吉幸晴
  • Organizer: 第110回日本外科学会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2010-04-10
• [Presentation] microRNAによる食道扁平上皮癌抗癌剤効果予測 (2010)
  • Author(s): 蔵重淳二
  • Organizer: 第64回日本食道学会学術集会
  • Place of Presentation: 福岡県石橋文化ホール・石橋美術館
• [Presentation] MicroRNA-21 and-26a are novel markers to predict the sensitivity to chemotherapy in esophageal squamous cell carcinoma. (2010)
  • Author(s): Kurashige J
  • Organizer: AACR 101st Annual Meeting
  • Place of Presentation: Washington
• [Presentation] Micro RNA-101 promotes apoptosis and suppresses proliferation in esophageal squamous cell carcinoma by repressing the polycomb group protein. (2010)
  • Author(s): Hiyoshi Y
  • Organizer: AACR 101st Annual Meeting
  • Place of Presentation: Washington
• [Presentation] Micro RNA-101 promotes apoptosis and suppresses proliferation in esophageal squamous cell carcinoma by repressing the polycomb group protein. (2010)
  • Author(s): Hiyoshi Y
  • Organizer: AACR 101^<st> Annual Meeting
  • Place of Presentation: Walter E Washington Convention Center
• [Presentation] MicroRNA-21 and -26a are novel markers to predict the sensitivity to chemotherapy in esophageal squamous cell carcinoma. (2010)
  • Author(s): Kurashige J
  • Organizer: AACR 101^<st> Annual Meeting
  • Place of Presentation: Walter E Washington Convention Center
• [Presentation] microRNAによる食道扁平上皮癌抗癌剤効果予測 (2010)
  • Author(s): 蔵重淳二
  • Organizer: 第64回日本食道学会学術集会
  • Place of Presentation: 石橋美術館
• [Presentation] PDCD4の発現低下によって食道扁平上皮癌細胞が浸潤能が増加し予後不良となる (2009)
  • Author(s): 日吉幸晴
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 神奈川県パシフィコ横浜
  • Year and Date: 2009-10-01
• [Presentation] PDCD4の発現低下によって食道扁平上皮癌細胞が浸潤能が増加し予後不良となる (2009)
  • Author(s): 日吉幸晴
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 神奈川 パシフィコ横浜
  • Year and Date: 2009-10-01
• [Presentation] 食道扁平上皮癌におけるp12CDK2-AP1発現の意義 (2009)
  • Author(s): 日吉幸晴
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: 大阪府大阪国際会議場
  • Year and Date: 2009-07-16
• [Presentation] 食道扁平上皮癌におけるp12CDK2-AP1発現の意義 (2009)
  • Author(s): 日吉幸晴
  • Organizer: 第64回日本消化器外科学会総会
  • Place of Presentation: 大阪 大阪国際会議場
  • Year and Date: 2009-07-16
• [Presentation] 食道扁平上皮癌におけるRAD001の有用性の検討 (2009)
  • Author(s): 平島浩太郎
  • Organizer: 第63回日本食道学会学術集会
  • Place of Presentation: 神奈川県パシフィコ横浜
  • Year and Date: 2009-06-25
• [Presentation] 食道扁平上皮癌におけるRAD001の有用性の検討 (2009)
  • Author(s): 平島浩太郎
  • Organizer: 第63回日本食道学会学術集会
  • Place of Presentation: 神奈川 パシフィコ横浜
  • Year and Date: 2009-06-25
• [Presentation] MicroRNA-21 regulates proliferation and invasion in esophagus squamous cell carcinoma. (2009)
  • Author(s): Hiyoshi Yukiharu
  • Organizer: AACR 100th Annual Meeting 2009
  • Place of Presentation: アメリカColorado Convention Center
  • Year and Date: 2009-04-18
• [Presentation] MicroRNA-21 regulates proliferation and invasion in esophagus squamous cell carcinoma (2009)
  • Author(s): 日吉幸晴
  • Organizer: AACR 100th Annual Meeting 2009
  • Place of Presentation: アメリカ COLORADO CONVENTION CENTER
  • Year and Date: 2009-04-18
• [Presentation] 食道扁平上皮癌におけるmicroRNAの発現・機能解析 (2009)
  • Author(s): 日吉幸晴
  • Organizer: 第109回日本外科学会
  • Place of Presentation: 福岡県福岡国際会議場
  • Year and Date: 2009-04-02
• [Presentation] 食道扁平上皮癌におけるmicroRNAの発現・機能解析 (2009)
  • Author(s): 日吉幸晴
  • Organizer: 第109回日本外科学会
  • Place of Presentation: 福岡 福岡国際会議場
  • Year and Date: 2009-04-02