Treatment strategy for micro-lymph node metastases using anti-tumoral immunological mechanism
| Project/Area Number |
21591707
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NATSUGOE Shoji 鹿児島大学, 大学院・医歯学総合研究科, 教授 (70237577)
NAKAJO Akihiro 鹿児島大学, 医学部・歯学部附属病院, 助教 (20404486)
KITAZONO Masaki 鹿児島大学, 医学部・歯学部附属病院, 助教 (30398276)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | リンパ節転移 / 抗腫瘍免疫機構 / リンパ節転移モデル / ケモカイン / HLA抗原 / 抗腫瘍免疫寄稿 / 抗腫瘍免疫 / 微小転移 / 転移モデル |
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| Research Abstract |
We tried to clarify the association between chemokine expression and clinicopathological factors in gastrointestinal cancer, moreover we investigated how host immune function affect for micro lymph node metastases using mouse model. We showed the expression of CD166 and CD168 in gastric cancer positively correlated with clinical factors and was selected as prognostic marker in gastric cancer for the first time. We could establish micro lymph node metastases model using GFP transfected B17F1 and C57BL.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Endoscopic ultrasonography is useful for monitoring the tumor response of neoadjuvant chemoradiation therapy in esophageal squamous cell carcinoma2012
Author(s)
Owaki T, Matsumoto M, Okumura H, Uchicado Y, Kita Y, Setoyama T, Sasaki K, Sakurai T, Omoto I, Shimada M, Sakamoto F, Yoshinaka H, Ishigami S, Ueno S, Natsugoe S.
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Journal Title
Am J Surg
Volume: 203(2)
Pages: 191-7
Related Report
Peer Reviewed
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[Journal Article] Clinical implication of CD166 expression in gastric cancer2011
Author(s)
Ishigami S, Ueno S, Arigami T, Arima H, Uchikado Y, Kita Y, Sasaki K, Nishizono Y, Omoto I, Kurahara H, Matsumoto M, Kijima Y, Natsugoe S.
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Journal Title
J Surg Oncol
Volume: 103
Pages: 57-61
Related Report
Peer Reviewed
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[Journal Article] Is delayed liver resection appropriate for patients with metachronous colorectal metastases?2011
Author(s)
Ueno S, Sakoda M, Kurahara H, Iino S, Minami K, Ando K, Mataki Y, Maemura K, Ishigami S, Takumi K, Fukukura Y, Natsugoe S.
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Journal Title
Ann Surg Oncol
Volume: 18
Pages: 1104-9
Related Report
Peer Reviewed
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[Journal Article] Safety and efficacy of early postoperative hyperbaric oxygen therapy with restriction of transfusions in patients with HCC who have undergone partial hepatectomy2011
Author(s)
Ueno S, Sakoda M, Kurahara H, Iino S, Minami K, Ando K, Mataki Y, Maemura K, Ishigami S, Shinchi H, Natsugoe S.
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Journal Title
Langenbecks Arch Surg
Volume: 396(1)
Pages: 99-106
Related Report
Peer Reviewed
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[Journal Article] Immediate breast reconstruction using autologous free dermal fat grafts provides better cosmetic results for patients with upper inner cancerous lesions2011
Author(s)
Kijima Y, Yoshinaka H, Funasako Y, Kaneko K, Hirata M, Mizoguchi T, Ishigami S, Arima H, Nakajo A, Ueno S, Natsugoe S.
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Journal Title
Surg Today
Volume: 41(4)
Pages: 477-89
NAID
Related Report
Peer Reviewed
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[Journal Article] Prognostic impact of CD168 expression in gastric cancer2011
Author(s)
Ishigami S, Ueno S, Nishizono Y, Matsumoto M, Kurahara H, Arigami T Uchikado Y, Setoyama T, Arima H, Yoshiaki K, Kijima Y, Kitazono M, Natsugoe S.
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Journal Title
BMC Cancer
Volume: 11
Pages: 106-106
NAID
Related Report
Peer Reviewed
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[Journal Article] Postoperative long-term evaluation of interposition reconstruction compared with Roux-en-Y after total gastrectomy in gastric cancer : prospective randomized controlled trial2011
Author(s)
Ishigami S, Natsugoe S, Hokita S, Aoki T, Kashiwagi H, Hirakawa K, Sawada T, Yamamura Y, Itoh S, Hirata K, Ohta K, Mafune K, Nakane Y, Kanda T, Furukawa H, Sasaki I, Kubota T, Kitajima M, Aikou T.
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Journal Title
Am J Surg
Volume: 202(3)
Pages: 247-53
Related Report
Peer Reviewed
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[Journal Article] Clinical implication of HLA class I expression in breast cancer2011
Author(s)
Kaneko K, Ishigami S, Kijima Y, Funasako Y, Hirata M, Okumura H, Shinchi H, Koriyama C, Ueno S, Yoshinaka H, Natsugoe S.
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Journal Title
BMC Cancer
Volume: 11
Pages: 454-454
NAID
Related Report
Peer Reviewed
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[Journal Article] Prognostic value of CD208-positive cell infiltration in gastric cancer2010
Author(s)
Ishigami S, Ueno S, Matsumoto M, Okumura H, Arigami T, Uchikado Y, Setoyama T, Arima H, Sasaki K, Kitazono M, Shinchi H, Kijima Y, Natsugoe S.
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Journal Title
Cancer Immunol Immunother
Volume: 59
Pages: 389-95
Related Report
Peer Reviewed
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[Journal Article] Prognostic impact of CD133 expression in gastric carcinoma2010
Author(s)
Ishigami S Ueno S, Arigami T, Uchikado Y, Setoyama T, Arima H, Kita Y, Kurahara H, Okumura H, Matsumoto M, Kijima Y, Natsugoe S.
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Journal Title
Anticancer Res
Pages: 2453-57
Related Report
Peer Reviewed
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[Journal Article] Roux-en-Y reconstruction with stapled distal jejunal pouch after total gastrectomy 2010 Am Surg 762010
Author(s)
Ishigami S Aridome K, Nakajo A, Matsumoto M, Uchikado Y, Setoyama T, Arigami T, Arima H, Ueno S, Kijima Y, Aikou T, Natsugoe S.
Volume
76
Pages
526-528
Related Report
Peer Reviewed
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[Journal Article] Nuclear expression of 14-3-3 sigma is related to prognosis in patients with esophageal squamous cell carcinoma2010
Author(s)
Okumura H, Kita Y, Yokomakura N, Uchikado Y, Setoyama T, Sakurai H, Omoto I, Matsumoto M, Owaki T, Ishigami S, Natsugoe S.
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Journal Title
Anticancer Res
Volume: 30
Pages: 5175-9
Related Report
Peer Reviewed
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