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Treatment strategy for micro-lymph node metastases using anti-tumoral immunological mechanism

Research Project

Project/Area Number 21591707
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKagoshima University

Principal Investigator

ISHIGAMI Sumiya  鹿児島大学, 歯学部附属病院, 講師 (90325803)

Co-Investigator(Kenkyū-buntansha) NATSUGOE Shoji  鹿児島大学, 大学院・医歯学総合研究科, 教授 (70237577)
NAKAJO Akihiro  鹿児島大学, 医学部・歯学部附属病院, 助教 (20404486)
KITAZONO Masaki  鹿児島大学, 医学部・歯学部附属病院, 助教 (30398276)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywordsリンパ節転移 / 抗腫瘍免疫機構 / リンパ節転移モデル / ケモカイン / HLA抗原 / 抗腫瘍免疫寄稿 / 抗腫瘍免疫 / 微小転移 / 転移モデル
Research Abstract

We tried to clarify the association between chemokine expression and clinicopathological factors in gastrointestinal cancer, moreover we investigated how host immune function affect for micro lymph node metastases using mouse model. We showed the expression of CD166 and CD168 in gastric cancer positively correlated with clinical factors and was selected as prognostic marker in gastric cancer for the first time. We could establish micro lymph node metastases model using GFP transfected B17F1 and C57BL.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (43 results)

All 2012 2011 2010 2009

All Journal Article (26 results) (of which Peer Reviewed: 26 results) Presentation (17 results)

  • [Journal Article] Endoscopic ultrasonography is useful for monitoring the tumor response of neoadjuvant chemoradiation therapy in esophageal squamous cell carcinoma2012

    • Author(s)
      Owaki T, Matsumoto M, Okumura H, Uchicado Y, Kita Y, Setoyama T, Sasaki K, Sakurai T, Omoto I, Shimada M, Sakamoto F, Yoshinaka H, Ishigami S, Ueno S, Natsugoe S.
    • Journal Title

      Am J Surg

      Volume: 203(2) Pages: 191-7

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical implication of CD166 expression in gastric cancer2011

    • Author(s)
      Ishigami S, Ueno S, Arigami T, Arima H, Uchikado Y, Kita Y, Sasaki K, Nishizono Y, Omoto I, Kurahara H, Matsumoto M, Kijima Y, Natsugoe S.
    • Journal Title

      J Surg Oncol

      Volume: 103 Pages: 57-61

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Is delayed liver resection appropriate for patients with metachronous colorectal metastases?2011

    • Author(s)
      Ueno S, Sakoda M, Kurahara H, Iino S, Minami K, Ando K, Mataki Y, Maemura K, Ishigami S, Takumi K, Fukukura Y, Natsugoe S.
    • Journal Title

      Ann Surg Oncol

      Volume: 18 Pages: 1104-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Safety and efficacy of early postoperative hyperbaric oxygen therapy with restriction of transfusions in patients with HCC who have undergone partial hepatectomy2011

    • Author(s)
      Ueno S, Sakoda M, Kurahara H, Iino S, Minami K, Ando K, Mataki Y, Maemura K, Ishigami S, Shinchi H, Natsugoe S.
    • Journal Title

      Langenbecks Arch Surg

      Volume: 396(1) Pages: 99-106

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oncoplastic surgery in Japanese patients with breast cancer close to the areola : partial mastectomy using periareolar mammoplasty : a case report2011

    • Author(s)
      Kijima Y, Yoshinaka H, Hirata M, Mizoguchi T, Ishigami S, Nakajo A, Arima H, Ueno S, Natsugoe S.
    • Journal Title

      Case Rep Surg

      Volume: 121985

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of BMP-7 in human gastric cancer and its clinical significance2011

    • Author(s)
      Aoki M, Ishigami S, Uenosono Y, Arigami T, Uchikado Y, Kita Y, Kurahara H, Matsumoto M, Ueno S, Natsugoe S.
    • Journal Title

      Br J Cancer

      Volume: 104(4) Pages: 714-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] B7-H3 expression in gastric cancer : a novel molecular blood marker for detecting circulating tumor cells2011

    • Author(s)
      Arigami T, Uenosono Y, Hirata M, Yanagita S, Ishigami S, Natsugoe S.
    • Journal Title

      Cancer Sci

      Volume: 102(5) Pages: 1019-24

    • NAID

      10029293581

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Increased Slug and decreased E-cadherin expression is related to poor prognosis in patients with gastric cancer2011

    • Author(s)
      Uchikado Y, Okumura H, Ishigami S, Setoyama T, Matsumoto M, Owaki T, Kita Y, Natsugoe S.
    • Journal Title

      Gastric Cancer

      Volume: 14(1) Pages: 41-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oncoplastic surgery combining partial mastectomy with breast reconstruction using a free nipple-areola graft for ductal carcinoma in situ in a ptotic breast : report of a case2011

    • Author(s)
      Kijima Y, Yoshinaka H, Hirata M, Mizoguchi T, Ishigami S, Arima H, Nakajo A, Ueno S, Natsugoe S.
    • Journal Title

      Surg Today

      Volume: 41(3) Pages: 390-5

    • NAID

      10029046191

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immediate breast reconstruction using autologous free dermal fat grafts provides better cosmetic results for patients with upper inner cancerous lesions2011

    • Author(s)
      Kijima Y, Yoshinaka H, Funasako Y, Kaneko K, Hirata M, Mizoguchi T, Ishigami S, Arima H, Nakajo A, Ueno S, Natsugoe S.
    • Journal Title

      Surg Today

      Volume: 41(4) Pages: 477-89

    • NAID

      10029046527

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of CD168 expression in gastric cancer2011

    • Author(s)
      Ishigami S, Ueno S, Nishizono Y, Matsumoto M, Kurahara H, Arigami T Uchikado Y, Setoyama T, Arima H, Yoshiaki K, Kijima Y, Kitazono M, Natsugoe S.
    • Journal Title

      BMC Cancer

      Volume: 11 Pages: 106-106

    • NAID

      120005367613

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Postoperative long-term evaluation of interposition reconstruction compared with Roux-en-Y after total gastrectomy in gastric cancer : prospective randomized controlled trial2011

    • Author(s)
      Ishigami S, Natsugoe S, Hokita S, Aoki T, Kashiwagi H, Hirakawa K, Sawada T, Yamamura Y, Itoh S, Hirata K, Ohta K, Mafune K, Nakane Y, Kanda T, Furukawa H, Sasaki I, Kubota T, Kitajima M, Aikou T.
    • Journal Title

      Am J Surg

      Volume: 202(3) Pages: 247-53

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical implication of HLA class I expression in breast cancer2011

    • Author(s)
      Kaneko K, Ishigami S, Kijima Y, Funasako Y, Hirata M, Okumura H, Shinchi H, Koriyama C, Ueno S, Yoshinaka H, Natsugoe S.
    • Journal Title

      BMC Cancer

      Volume: 11 Pages: 454-454

    • NAID

      120005367612

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical implication of HLA class I expression in breast cancer2011

    • Author(s)
      Kaneko K, Ishigami S
    • Journal Title

      BMC Cancer

      Volume: 20 Issue: 1 Pages: 454-454

    • DOI

      10.1186/1471-2407-11-454

    • NAID

      120005367612

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of CD168 expression in gastric cancer2011

    • Author(s)
      Ishigami S
    • Journal Title

      BMC Cancer

      Volume: 11 Issue: 1 Pages: 106-106

    • DOI

      10.1186/1471-2407-11-106

    • NAID

      120005367613

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of B7-H4 in blood of patients with gastric cancer predicts tumor progression and prognosis2010

    • Author(s)
      Arigami T, Uenosono Y, Hirata M, Hagihara T, Yanagita S, Ishigami S, Natsugoe S.
    • Journal Title

      J Surg Oncol

      Volume: 102(7) Pages: 748-52

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic value of CD208-positive cell infiltration in gastric cancer2010

    • Author(s)
      Ishigami S, Ueno S, Matsumoto M, Okumura H, Arigami T, Uchikado Y, Setoyama T, Arima H, Sasaki K, Kitazono M, Shinchi H, Kijima Y, Natsugoe S.
    • Journal Title

      Cancer Immunol Immunother

      Volume: 59 Pages: 389-95

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of CD133 expression in gastric carcinoma2010

    • Author(s)
      Ishigami S Ueno S, Arigami T, Uchikado Y, Setoyama T, Arima H, Kita Y, Kurahara H, Okumura H, Matsumoto M, Kijima Y, Natsugoe S.
    • Journal Title

      Anticancer Res

      Pages: 2453-57

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roux-en-Y reconstruction with stapled distal jejunal pouch after total gastrectomy 2010 Am Surg 762010

    • Author(s)
      Ishigami S Aridome K, Nakajo A, Matsumoto M, Uchikado Y, Setoyama T, Arigami T, Arima H, Ueno S, Kijima Y, Aikou T, Natsugoe S.
    • Volume
      76
    • Pages
      526-528
    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nuclear expression of 14-3-3 sigma is related to prognosis in patients with esophageal squamous cell carcinoma2010

    • Author(s)
      Okumura H, Kita Y, Yokomakura N, Uchikado Y, Setoyama T, Sakurai H, Omoto I, Matsumoto M, Owaki T, Ishigami S, Natsugoe S.
    • Journal Title

      Anticancer Res

      Volume: 30 Pages: 5175-9

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Oncoplastic surgery in a Japanese patient with breast cancer in the lower inner quadrant area : partial mastectomy using horizontal reduction mammoplasty2010

    • Author(s)
      Kijima Y, Yoshinaka H, Hirata M, Mizoguchi T, Ishigami S, Nakajo A, Arima H, Ueno S, Natsugoe S.
    • Journal Title

      Breast Cancer

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ESD時代の外科治療2010

    • Author(s)
      石神純也
    • Journal Title

      臨床外科

      Volume: 65 Pages: 1108-1111

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of CD133 expression in gastric carcinoma2010

    • Author(s)
      Ishigami S
    • Journal Title

      Anticancer Res

      Volume: 30 Pages: 2453-2457

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Roux-en-Y reconstruction with stapled distal jejunal pouch after total gastrectomy2010

    • Author(s)
      Ishigami S
    • Journal Title

      Am Surg

      Volume: 76 Pages: 526-528

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 食道胃接合部癌の特徴 Barrett 食道癌、胃上部癌との比較外科の立場から2009

    • Author(s)
      石神純也
    • Journal Title

      胃と腸 44

      Pages: 1095-1103

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prognostic value of CD208-positive cell infiltration in gastric cancer2009

    • Author(s)
      石神純也
    • Journal Title

      Cancer Immunol Immunother 59

      Pages: 389-95

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 食道胃接合部癌の臨床状理学的特徴と治療戦略(シンポジウム)2011

    • Author(s)
      石神純也
    • Organizer
      第73回日本臨床外科学会総会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Year and Date
      2011-11-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 胃癌における腫瘍DLL4 (delta-like ligand 4)の発現について2011

    • Author(s)
      石神純也
    • Organizer
      第49回日本癌治療学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2011-10-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Roux-en-Y reconstruction with stapled distal jejunal pouch after total gastrectomy2011

    • Author(s)
      石神純也
    • Organizer
      International Surgical week
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2011-08-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] stage IV胃癌に対する化療後追加手術の有用性について(パネルディスカッション)2011

    • Author(s)
      石神純也
    • Organizer
      第111回日本外科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高度進行胃癌に対する審査腹腔鏡の診断成績2010

    • Author(s)
      石神純也
    • Organizer
      第23回日本内視鏡外科学会総会
    • Place of Presentation
      横浜市神奈川県
    • Year and Date
      2010-10-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 高度進行胃癌に対する審査腹腔鏡の診断成績2010

    • Author(s)
      石神純也
    • Organizer
      第23回日本内視鏡外科学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2010-10-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Therapeutic strategy in esophagogastric junction cancer2010

    • Author(s)
      石神純也
    • Organizer
      9^<th> International Conference of the Asian Clinical Oncology Society
    • Place of Presentation
      岐阜市岐阜県
    • Year and Date
      2010-08-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Therapeutic strategy in esophasogastric junction cance2010

    • Author(s)
      石神純也
    • Organizer
      9^<th> International Conference of the Asian Clinical Oncology Society
    • Place of Presentation
      岐阜市
    • Year and Date
      2010-08-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 高度進行胃癌に対する化療後の追加外科手術の有用性について2010

    • Author(s)
      石神純也
    • Organizer
      第65回日本消化器外科学会総会
    • Place of Presentation
      下関市山口県
    • Year and Date
      2010-07-14
    • Related Report
      2011 Final Research Report
  • [Presentation] 高度進行胃癌に対する化療後の追加外科手術の有用性について2010

    • Author(s)
      石神純也
    • Organizer
      第65回日本消化器外科学会総会
    • Place of Presentation
      下関市
    • Year and Date
      2010-07-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Salvage surgery following chemotherapy for stage IV gastric cancer2010

    • Author(s)
      石神純也
    • Organizer
      The 17th Czech-Japan Surgical Symposium
    • Place of Presentation
      金沢市石川県
    • Year and Date
      2010-06-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Salvage surgery following chemotherapy for stage IV gastric cancel2010

    • Author(s)
      石神純也
    • Organizer
      The 17th Czech-Japan Surgical Symposium
    • Place of Presentation
      金沢市
    • Year and Date
      2010-06-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] StageIV進行胃癌に対する化療後のR0手術の有用性2010

    • Author(s)
      石神純也
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋市愛知県
    • Year and Date
      2010-04-08
    • Related Report
      2011 Final Research Report
  • [Presentation] StageIV進行胃癌に対する化療後のRO手術の有用性2010

    • Author(s)
      石神純也
    • Organizer
      第110回日本外科学会定期学術集会
    • Place of Presentation
      名古屋市
    • Year and Date
      2010-04-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胃全摘後RouX-Y法Y脚部パウチ再建法2010

    • Author(s)
      石神純也
    • Organizer
      第72回日本臨床外科学会総会
    • Place of Presentation
      名古屋市愛知県
    • Related Report
      2011 Final Research Report
  • [Presentation] 胃全摘後RouX-Y法 Y脚部パウチ再建法2010

    • Author(s)
      石神純也
    • Organizer
      第72回日本臨床外科学会総会
    • Place of Presentation
      横浜市
    • Related Report
      2010 Annual Research Report
  • [Presentation] 宿主免疫応答からみた胃癌侵潤リンパ球の評価と臨床的意義2009

    • Author(s)
      石神純也
    • Organizer
      第109回日本外科学会定期学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2009-04-02
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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