| Project/Area Number |
21591707
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NATSUGOE Shoji 鹿児島大学, 大学院・医歯学総合研究科, 教授 (70237577)
NAKAJO Akihiro 鹿児島大学, 医学部・歯学部附属病院, 助教 (20404486)
KITAZONO Masaki 鹿児島大学, 医学部・歯学部附属病院, 助教 (30398276)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Keywords | リンパ節転移 / 抗腫瘍免疫機構 / リンパ節転移モデル / ケモカイン / HLA抗原 / 抗腫瘍免疫寄稿 / 抗腫瘍免疫 / 微小転移 / 転移モデル |
|---|
| Research Abstract |
We tried to clarify the association between chemokine expression and clinicopathological factors in gastrointestinal cancer, moreover we investigated how host immune function affect for micro lymph node metastases using mouse model. We showed the expression of CD166 and CD168 in gastric cancer positively correlated with clinical factors and was selected as prognostic marker in gastric cancer for the first time. We could establish micro lymph node metastases model using GFP transfected B17F1 and C57BL.
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