A novel therapeutic strategy for colorectal cancer using stromal cells

• Project/Area Number: 21591708
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Sapporo Medical University
• Principal Investigator: FURUHATA Tomohisa 札幌医科大学, 医学部, 准教授 (80359992)
• Co-Investigator(Kenkyū-buntansha): NISHIDATE Toshihiko 札幌医科大学, 医学部, 助教 (80404606) ; KIMURA Yasutoshi 札幌医科大学, 医学部, 講師 (80311893) ; OKITA Kenji 札幌医科大学, 医学部, 助教 (70517911)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 大腸癌 / VEGF-A / マクロファージ / 線維芽細胞 / 間質細胞 / 血管新生 / VEGF / 繊維芽細胞 / p73 / 纎維芽細胞

Research Abstract

VEGF-A expression in stromal tissue is thought to be a better prognostic factor and VEGF165b, which is mainly expressed in stromal tissue, inhibits the angiogenesis in colorectal cancer

Research Products

• [Journal Article] Vascular endothelial growth factor 165b expression in stromal cells and colorectal cancer (2011)
  • Author(s): Tayama M, Furuhata T, Inafuku Y, Okita K, Nishidate T, Mizuguchi T, Kimura Y, Hirata K
  • Journal Title: World J Gastroenterol Volume: 17(44) Pages: 4867-74
  • Peer Reviewed
• [Journal Article] Vascular endothelial growth factor 165b expression in stromal cells and colorectal cancer (2011)
  • Author(s): Tayama M, Furuhata T
  • Journal Title: World J Gastroenterol Volume: 17 Pages: 4867-4874
  • Peer Reviewed
• [Journal Article] Phase II study of S-1 plus leucovorin in patients with metastatic colorectal cancer (2010)
  • Author(s): Koizumi W, Boku N, Yamaguchi K, Miyata Y, Sawaki A, Kato T, Toh Y, Hyodo I, Nishina T, Furuhata T, Miyashita K, Okada Y
  • Journal Title: Ann Oncol Volume: 21(4) Pages: 766-71
  • Peer Reviewed
• [Journal Article] Phase II study of S-1 plus leucovorin in patients with metastatic colorectal cancer. (2010)
  • Author(s): Koizumi W, Furuhata T
  • Journal Title: Ann Oncol Volume: 21(4) Pages: 766-771
  • Peer Reviewed
• [Journal Article] Effects of a low-fat meal on the oral bioavailability of UFT and leucovorin in patients with colorectal cancer (2009)
  • Author(s): Furuhata T, Meguro M, Nishidate T, Okita K, Ishiyama G, Iwayama Y, Hosokawa Y, Tsuruma T, Kimura Y, Mizuguchi T, Sasaki K.
  • Journal Title: Int J Clin Oncol Volume: 14(6) Pages: 529-33
  • NAID: 10027201344
  • Peer Reviewed
• [Journal Article] Clinical compliance with an oral uracil/tegafur(UFT) plus leucovorin(LV) regimen as adjuvant chemotherapy in Japanese colorectal cancer patients (2009)
  • Author(s): Meguro M, Furuhata T, Okita K, Nishidate T, Ishiyama G, Iwayama Y, Kimura Y, Mizuguchi T, Hirata K
  • Journal Title: Int J Clin Oncol Volume: 14(5) Pages: 402-7
  • NAID: 10027200833
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinase-2 expression in stromal tissues is a consistent prognostic factor in stage II colon cancer (2009)
  • Author(s): Inafuku Y, Furuhata T, Tayama M, Okita K, Nishidate T, Mizuguchi T, Kimura Y, Hirata K
  • Journal Title: Cancer Sci Volume: 100(5) Pages: 852-8
  • NAID: 10025145524
  • Peer Reviewed
• [Journal Article] Effects of a low-fat meal on the oral bioavailability of UFT and leucovorin in patients with colorectal cancer (2009)
  • Author(s): Furuhata T
  • Journal Title: Int J Clin Oncol. 14 Pages: 529-533
  • NAID: 10027201344
  • Peer Reviewed
• [Journal Article] Clinical compliance with an oral uracil/tegafur(UFT)plus leucovorin(LV)regimen as adjuvant chemotherapy in Japanese colorectal cancer patients (2009)
  • Author(s): Meguro M
  • Journal Title: Int J Clin Oncol. 14 Pages: 402-407
  • Peer Reviewed
• [Journal Article] Matrix metalloproteinase-2 expression in stromal tissues is a consistent prognostic factor in stage II colon cancer (2009)
  • Author(s): Inafuku Y
  • Journal Title: Cancer Sci. 100 Pages: 852-858
  • Peer Reviewed
• [Presentation] MMP-2発現解析によるStgae2結腸癌の悪性度診断 (2010)
  • Author(s): 田山誠、古畑智久
  • Organizer: 第65回日本消化器外科学会総会
  • Place of Presentation: 下関
  • Year and Date: 2010-07-15
• [Presentation] 大腸癌におけるVEGF165b発現解析の臨床的意義 (2010)
  • Author(s): 古畑智久
  • Organizer: 第110回日本外科学会定期学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2010-04-10
• [Presentation] Matrix metalloproteinase 2 expression in stromal tissues is a consistent prognostic factor in Stage II colon cancer (2009)
  • Author(s): Furuhata T
  • Organizer: International Surgical Week 2009
  • Place of Presentation: Adelaide, Australia
  • Year and Date: 2009-09-07
• [Presentation] Matrix metalloproteinase-2 expression in stromal tissues is a consistent prognostic factor in Stage II colon cancer (2009)
  • Author(s): Furuhata T
  • Organizer: International Surgical Week 2009
  • Place of Presentation: アデレード, オーストラリア
  • Year and Date: 2009-09-07