Predisposition of cancer development by global analysis of DNA methylation alterations
| Project/Area Number |
21591710
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Jichi Medical University |
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Principal Investigator |
SUZUKI Koichi 自治医科大学, 医学部, 助教 (70332369)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 遺伝子修飾異常 / 脱メチル化異常 / メチル化異常 / 潰瘍性大腸炎 / ヘリコバクターピロリ胃炎 / 大腸癌 / 胃癌 / 癌易罹患性 / 脱メチル化 / メチル化 |
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| Research Abstract |
We evaluated the levels of demethylation alterations in normal tissues from patients who had undergone gastrectomy or colectomy due to cancer development. Our data showed that high levels of demethylation alterations were frequently seen in patients who developed synchronous or metachronous double cancers as compare with those did not. Further, we developed a novel microarray platform based on methylation-sensitive amplified fragment length polymorphism DNA fingerprinting to perform the genome-wide severance of methylation alterations, which would enable us to make biological profiles according to the several diseases including cancer.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] 1, Array-based identification of common DNA methylation alterations in ulcerative colitis2012
Author(s)
Koizumi K, Alonso S, Miyaki Y, Okada S, Ogura H, Shiiya N, Konishi F, Taya T, Perucho M, Suzuki K
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Journal Title
Oncology Reports
Volume: 40
Pages: 983-994
DOI
Related Report
Peer Reviewed
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[Journal Article] 2, Aberrant methylation of the Pleckstrin and Sec7 domain-containing gene is implicated in ulcerative colitis-associated carcinogenesis through its inhibitory effect on apoptosis2012
Author(s)
Okada S, Suzuki K, Takaharu K, Noda H, Kamiyama H, Maeda T, Saito M, Koizumi K, Miyaki Y, Konishi F
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Journal Title
Int J Oncol
Volume: 40
Pages: 686-694
DOI
Related Report
Peer Reviewed
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[Journal Article] 7, Identification of a potent epigenetic biomarker for resistance to caraptothecin and poor outcome to irinotecan-based chemotherapy in colon cancer2012
Author(s)
Miyaki Y, Suzuki K, Koizumi K, Kato T, Saito M, Kamiyama H, Maeda T, Shibata K, Shiya N, Konishi F
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Journal Title
Int J Oncol
Volume: 40
Pages: 217-226
DOI
Related Report
Peer Reviewed
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[Presentation] Rac1-mediated immune systems, governing machinery of apoptosis and neutrophils chemotaxis, in ulcerative colitis-associated carcinogenesis2011
Author(s)
加藤高晴, 鈴木浩一, 岡田晋一郎, 神山英範, 前田孝文, 齊藤正昭, 宮木祐一郎, 小泉圭, 小西文雄
Organizer
第7回免疫アジュバント研究会
Place of Presentation
福島
Year and Date
2011-10-07
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