Research of the characteristics of disseminated gastric cancer cells and the factors of sensitivity and tolerance to chemotherapeutic agents.

• Project/Area Number: 21591713
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Tokyo Women's Medical University
• Principal Investigator: HAYASHI Kazuhiko 東京女子医科大学, 医学部, 教授 (10208613)
• Co-Investigator(Kenkyū-buntansha): KURAMOCHI Hidekazu 東京女子医科大学, 医学部, 助教 (30287362) ; KAMIKODURU Hirotaka 東京女子医科大学, 医学部, 助教 (40328430)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 十二指腸外科学 / 胃癌 / 腹膜播種 / 消化器癌 / 抗癌剤耐性

Research Abstract

We planned the drug sensitivity test using gastric cancer cell line knocked down Osteopontin(OPN), however it did not work well. We next tried this work with colon cancer cell line. The colon cancer cell line which is knocked OPN down with specific siRNA has required 5FU resistance compared to control cell line. The difference was not observed when docetaxel was exposed.

Research Products

• [Journal Article] 各論胆道癌の個別化医療化学療法を中心に(癌個別化医療はどこまですすんだのか) (2011)
  • Author(s): 林和彦, 他4名
  • Journal Title: 外科 Volume: 73巻10号 Pages: 1069-1072
• [Journal Article] Epidermal growth factor receptor(EGFR) mRNA levels and protein expression levels in primary colorectal cancer and corresponding liver metastases (2010)
  • Author(s): 林和彦, 他5名
  • Journal Title: Cancer chemotherapy and pharmacology Volume: 65(5) Pages: 825-831
• [Presentation] 胃癌5-FU耐性株におけるLV併用効果の基礎的検討 (2011)
  • Author(s): 林和彦, 他3名
  • Organizer: ミニシンポジウム5, TR・基礎,第49回日本癌治療学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-28
• [Presentation] Osteopontin Gene Expression Correlate with Patients Survival in Colorectal Cancer Patients with Synchronous Liver Metastasis (2011)
  • Author(s): 林和彦, 他6名
  • Organizer: AACR Annual Meeting 2011
  • Place of Presentation: Orlando FL USA
  • Year and Date: 2011-04-06
• [Presentation] Osteopontin gene expression correlate with patients survival in colorectal cancer patients with synchronous liver metastasis (2011)
  • Author(s): 中島豪
  • Organizer: AACR Annual meeting 2011
  • Place of Presentation: Orlando, Florida, U.S.A.
  • Year and Date: 2011-04-06
• [Presentation] 腹腔内洗浄液の癌関連遺伝子発現解析による胃癌の腹膜転移診断 (2010)
  • Author(s): 林和彦, 他10名
  • Organizer: 口演46,胃診断・その他1第48回日本癌治療学会学術集会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-29
• [Presentation] 腹腔内洗浄液の癌関連遺伝子発現解析による胃癌の腹膜転移診断 (2010)
  • Author(s): 芹澤朗子
  • Organizer: 第48回日本癌治療学会総会
  • Place of Presentation: 京都
  • Year and Date: 2010-10-29
• [Presentation] 胃癌患者における腹腔洗浄細胞液の癌関連遺伝子発現解析 (2010)
  • Author(s): 芹澤朗子、林和彦
  • Organizer: 第41回東京女子医科大学消化器病センター例会
  • Place of Presentation: 東京
• [Presentation] 胃癌治療における緩和手術の役割 (2009)
  • Author(s): 林和彦, 他8名
  • Organizer: 臨床外科学会,第71回日本臨床外科学会総会
  • Place of Presentation: 京都
  • Year and Date: 2009-11-20
• [Presentation] S-1併用Docetaxel腹腔内投与化学療法が著効し、根治手術をしえた腹膜播種を伴う4型胃癌の1例 (2009)
  • Author(s): 林和彦, 他11名
  • Organizer: 臨床外科学会,第71回日本臨床外科学会総会
  • Place of Presentation: 京都
  • Year and Date: 2009-11-20