| Project/Area Number |
21591714
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKIZAWA Toshihiro 日本医科大学, 大学院・医学研究科, 教授 (90271220)
ISHIBASHI Osamu 日本医科大学, 医学部, 護師 (70293214)
MAKINO Kouji 日本医科大学, 医学部, 准教授 (30267207)
NOMURA Tsutomu 日本医科大学, 医学部, 准教授 (60287737)
HAGIWARA Nobutoshi 日本医科大学, 医学部, 助教 (00328824)
赤城 一郎 日本医科大学, 医学部, 助教 (90552662)
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| Co-Investigator(Renkei-kenkyūsha) |
AKAGI Ichiro 日本医科大学, 医学部, 助教 (90552662)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 食道外科学 / 食道癌 / MicroRNA / SnoN / MiR-720 / MiR-1274A / MiR-1274B / p63 / ADAM9 / SonN / miRNA |
|---|
| Research Abstract |
The target miRNAs for SnoN were investigated in esophageal cancer. Using human esophageal cancer cell lines, SnoN expression was inhibited using siRNA, and altered miRNAs were identified as miR-720, miR-1274A, miR-1274B with p63 and ADAM9 as the possible relevant genes. The induction of SnoN expression was positively correlated to miRNA expression. However, the effect of SnoN expression on cell growth is still unclear and needs further investigation.
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