Association of perioperative changes in plasma and salivary substance P with cough reflex sensitivity and postoperative aspiration after esophagectomy
| Project/Area Number |
21591716
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SHIOZAKI Hitoshi 近畿大学, 学長 (70144475)
IMAMOTO Haruhiko 近畿大学, 医学部, 教授 (80351609)
IMANO Motohiro 近畿大学, 医学部, 准教授 (00278681)
SHINKAI Masayuki 近畿大学, 医学部, 講師 (80340793)
PENG Ying-feng 近畿大学, 医学部, 非常勤講師 (20411605)
YASUDA Atsushi 近畿大学, 医学部, 講師 (60351615)
SHIRAISHI Osamu 近畿大学, 医学部・附属病院, 講師 (70388536)
NISHIKI Kouhei 近畿大学, 医学部・附属病院, 助教 (90441039)
KATO Hiroaki 近畿大学, 医学部・附属病院, 助教 (30460900)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | サブスタンスP / 誤嚥 / 食道切除術 / 咳嗽反射 / 嚥下機能 / 食道癌 / 誤嚥性肺炎 / 外層反射 |
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| Research Abstract |
Aspiration of elderly patients is caused by decreased secretion of substance P(SP) that regulates cough and swallowing reflexes. We prospectively investigated the change of perioperative plasma SP concentration in patients with esophageal cancer undergoing esophagectomy and examined the association with development of aspiration. The plasma SP concentration did not show a significant change in the perioperative period. However, decreased preoperative SP concentration had a strong association with postoperative aspiration(p=0.004), suggesting that patients with decreased preoperative plasma SP concentration(60 pg/ml or less) might carry a higher risk of development of postoperative aspiration in patients after esophagectomy.
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Report
(4 results)
Research Products
(8 results)
