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Association of perioperative changes in plasma and salivary substance P with cough reflex sensitivity and postoperative aspiration after esophagectomy

Research Project

Project/Area Number 21591716
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionKinki University

Principal Investigator

YASUDA Takushi  近畿大学, 医学部, 准教授 (10324782)

Co-Investigator(Kenkyū-buntansha) SHIOZAKI Hitoshi  近畿大学, 学長 (70144475)
IMAMOTO Haruhiko  近畿大学, 医学部, 教授 (80351609)
IMANO Motohiro  近畿大学, 医学部, 准教授 (00278681)
SHINKAI Masayuki  近畿大学, 医学部, 講師 (80340793)
PENG Ying-feng  近畿大学, 医学部, 非常勤講師 (20411605)
YASUDA Atsushi  近畿大学, 医学部, 講師 (60351615)
SHIRAISHI Osamu  近畿大学, 医学部・附属病院, 講師 (70388536)
NISHIKI Kouhei  近畿大学, 医学部・附属病院, 助教 (90441039)
KATO Hiroaki  近畿大学, 医学部・附属病院, 助教 (30460900)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsサブスタンスP / 誤嚥 / 食道切除術 / 咳嗽反射 / 嚥下機能 / 食道癌 / 誤嚥性肺炎 / 外層反射
Research Abstract

Aspiration of elderly patients is caused by decreased secretion of substance P(SP) that regulates cough and swallowing reflexes. We prospectively investigated the change of perioperative plasma SP concentration in patients with esophageal cancer undergoing esophagectomy and examined the association with development of aspiration. The plasma SP concentration did not show a significant change in the perioperative period. However, decreased preoperative SP concentration had a strong association with postoperative aspiration(p=0.004), suggesting that patients with decreased preoperative plasma SP concentration(60 pg/ml or less) might carry a higher risk of development of postoperative aspiration in patients after esophagectomy.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report

Research Products

(8 results)

All 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (6 results)

  • [Journal Article] 血中・唾液中サブスタンスP濃度測定とクエン酸誘発咳嗽反射閾値検査による食道癌術後誤嚥性肺炎のリスク評価2010

    • Author(s)
      中森康浩、安田卓司、今本治彦、加藤寛章、岩間密、白石治、安田篤、彭英峰、新海政幸、今野元博、塩崎均
    • Journal Title

      近畿大学医学雑誌

      Volume: Vol.35, No.1 Pages: 31-40

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 血中・唾液中サブスタンスP濃度測定とクエン酸誘発咳反射閾イ面検査による食道癌術後誤嚥性肺炎のリスク評価2010

    • Author(s)
      中森康浩、安田卓司, 他
    • Journal Title

      近畿大学医学雑誌

      Volume: 35 Pages: 31-40

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 食道癌術後嚥下障害に対する術式および術後管理の工夫2011

    • Author(s)
      安田卓司, 他
    • Organizer
      第18回外科フォーラム
    • Place of Presentation
      東京、ホテルオークラ東京
    • Year and Date
      2011-07-30
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 高齢者胃癌症例に対する開腹手術と鏡視下手術の比較2011

    • Author(s)
      安田篤, 他
    • Organizer
      第66回日本消化器外科学会総会
    • Place of Presentation
      名古屋、名古屋国際会議場
    • Year and Date
      2011-07-14
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Low preoperative concentration of plasma substance P in elderly patients is a significant risk factor for aspiration pneumonia after esophagectomy for esophageal cancer2010

    • Author(s)
      Nakamori Y, et al.
    • Organizer
      12th World Congress of the International Society for Diseases of the Esophagus
    • Place of Presentation
      鹿児島・城山観光ホテル
    • Year and Date
      2010-09-03
    • Related Report
      2011 Final Research Report
  • [Presentation] Low preoperative concentration of plasma substance P in elderly patients is a significant risk factor for aspiration pneumonia after esophagectomy for esophageal cancer.2010

    • Author(s)
      Nakamori Y, Yasuda T, et al.
    • Organizer
      12th World Congress of the International Society for Diseases of the Esophagus (ISDE)
    • Place of Presentation
      鹿児島・城山観光ホテル
    • Year and Date
      2010-09-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] クエン酸誘発咳嗽反射閾値検査による食道癌術後誤嚥性肺炎のリスク評価2010

    • Author(s)
      中森康浩, 他
    • Organizer
      第110回日本外科学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2010-04-08
    • Related Report
      2011 Final Research Report
  • [Presentation] クエン酸誘発咳漱反射閾値検査による食道癌術後誤嚥性肺炎のリスク評価2010

    • Author(s)
      中森康浩、安田卓司, 他
    • Organizer
      第110回日本外科学会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2010-04-08
    • Related Report
      2010 Annual Research Report

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Published: 2009-03-31   Modified: 2016-04-21  

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