Application of Serum Antibodies against Multiple Tumor Antigen to Diagnose Esophageal Squamous Cell Carcinoma

• Project/Area Number: 21591717
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Toho University
• Principal Investigator: SHIMADA Hideaki 東邦大学, 医学部, 教授 (20292691)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: SEREX / VEGF / p53 / ELISA / 食道癌 / 血清抗体 / 腫瘍マーカー

Research Abstract

Purpose of this study was(i) establish ELISA system to detect serum anti-VEGF antibodies, and(ii) evaluate positive rate of serum anti-VEGF antibodies in patients with esophageal squamous cell carcinoma. Using a cut-off value of mean+3SD of serum anti-VEGF antibody level of healthy controls, positive rate of patients with esophageal squamous cell carcinoma was 6.6%(6/91). No clinicopathological factors were associated with presence of anti-VEGF antibodies.

Research Products

• [Journal Article] Adhesion molecule periplakin is involved in cellular movement and attachment in pharyngeal squamous cancer cells (2011)
  • Author(s): Tonoike Y, Matsushita K, Tomonaga T, Katada K, Tanaka N, Shimada H, Nakatani Y, Okamoto Y, Nomura F
  • Journal Title: BMC cell biology Volume: 12(1) Pages: 41-41
  • Peer Reviewed
• [Journal Article] Identification of a novel SEREX antigen family, ECSA, in esophageal squamous cell carcinoma (2011)
  • Author(s): Kagaya A, Shimada H, Shiratori T, Kuboshima M, Nakashima-Fujita K, Yasuraoka M, Nishimori T, Kurei S, Hachiya T, Murakami A, Tamura Y, Nomura F, Ochiai T, Matsubara H, Takiguchi M, Hiwasa T.
  • Journal Title: Proteome Science Volume: 9 Issue: 8 Pages: 31-31
  • DOI: 10.1002/jso.22127
  • Peer Reviewed
• [Journal Article] Adhesion molecule periplakin is involved in cellular movement and attachment in pharyngeal squamous cancer cells (2011)
  • Author(s): Tonoike Y, Matsushita K…, Shimada H, et al.(6番目/9人中)
  • Journal Title: BMC cell biology Volume: 12(1) Issue: 1 Pages: 41-41
  • DOI: 10.1186/1471-2121-12-41
  • Peer Reviewed
• [Journal Article] Identification of a novel SEREX antigen family, ECSA, in esophageal squamous cell carcinoma (2011)
  • Author(s): Kagaya A, Shimada H, Shiratori T, et al.(2番目/17人中)
  • Journal Title: Proteome Science Volume: 9 Issue: 1 Pages: 31-31
  • DOI: 10.1186/1477-5956-9-31
  • Peer Reviewed
• [Journal Article] High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer (2010)
  • Author(s): Shimada H, Takiguchi N, Kainuma O, Soda H, Ikeda A, Cho A, Miyazaki A, Gunji H, Yamamoto H, Nagata M
  • Journal Title: Gastric Cancer Volume: 13(3) Issue: 3 Pages: 170-176
  • DOI: 10.1007/s10120-010-0554-3
  • Peer Reviewed
• [Journal Article] Angiogenesis-related factors are molecular targets for diagnosis and treatment patients with esophageal carcinoma (2010)
  • Author(s): Oshima Y, Yajima S, Yamazaki K, Matsushita K, Tagawa M, Shimada H
  • Journal Title: Ann Thorac Cardiovasc Surg Volume: 16(6) Pages: 389-393
  • NAID: 10029685984
  • URL: http://www.atcs.jp/pdf/2010_16_6/389.pdf
  • Peer Reviewed
• [Journal Article] 腫瘍マーカー血清p53抗体-診断モニタリング- (2010)
  • Author(s): 島田英昭, 山崎有浩, 谷島聡, 大嶋陽幸, 小池淳一
  • Journal Title: 日本臨床 Volume: 68 Pages: 829-832
  • Peer Reviewed
• [Journal Article] High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer. (2010)
  • Author(s): Shimada H, Takiguchi N, Kainuma O, Soda H, Ikeda A, Cho A, Miyazaki A, Gunji H, Yamamoto H, Nagata M
  • Journal Title: Gastric Cancer Volume: 13(3) Pages: 170-176
  • Peer Reviewed
• [Journal Article] Angiogenesis-related factors are molecular targets for diagnosis and treatment patients with esophageal carcinoma. (2010)
  • Author(s): Oshima Y, Yajima S, Yamazaki K, Matsushita K, Tagawa M, Shimada H
  • Journal Title: Ann Thorac Cardiovasc Surg Volume: 16(6) Pages: 389-393
  • NAID: 10029685984
  • Peer Reviewed
• [Journal Article] 腫瘍マーカー 血清p53抗体-診断モニタリング- (2010)
  • Author(s): 島田英昭, 山崎有浩, 谷島聡, 大嶋陽幸, 小池淳一
  • Journal Title: 日本臨床 Volume: 68(Suppl7) Pages: 829-832
  • Peer Reviewed
• [Journal Article] Perioperative Changes of Serum p53 Antibody Titer is a Predictor for Survival in Patients with Esophageal Squamous Cell Carcinoma (2009)
  • Author(s): Shimada H, Shiratori T, Takeda A, Matsushita K, Okazumi S, Akutsu Y, Matsubara H, Nomura F, Ochiai T
  • Journal Title: World J Surg Volume: 33 Issue: 2 Pages: 272-277
  • DOI: 10.1007/s00268-008-9821-4
  • Peer Reviewed
• [Journal Article] Detection of anti-CUEC-23 antibodies in serum of patients with esophageal squamous cell carcinoma : a possible new serum marker for esophageal cancer (2009)
  • Author(s): Shimada H, Kagaya A, Shiratori T, Nomura F, Takiguchi M, Matsubara H, Hiwasa T
  • Journal Title: J Gastroenterol Volume: 44 Issue: 7 Pages: 691-696
  • DOI: 10.1007/s00535-009-0060-8
  • NAID: 10025176091
  • Peer Reviewed
• [Journal Article] Perioperative Changes of Serum p53 Antibody Titer is a Predictor for Survival in Patients with Esophageal Squamous Cell Carcinoma (2009)
  • Author(s): Shimada H, et al
  • Journal Title: World Journal of Surgery 33 Pages: 272-272
  • Peer Reviewed
• [Journal Article] Detection of anti-CUEC-23 antibodies in serum of patients with esophageal squamous cell carcinoma : a possible new serum marker for esophageal cancer (2009)
  • Author(s): Shimada H, et al.
  • Journal Title: Journal of Gastroenterology 44 Pages: 691-691
  • NAID: 10025176091
  • Peer Reviewed
• [Presentation] 癌診療におけるp53抗体マーカーの有用性～PUBMED文献から～ (2011)
  • Author(s): 島田英昭
  • Organizer: 第73回日本臨床外科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-11-17
• [Presentation] 癌診療におけるp53抗体マーカーの有用性～PUBMED文献から～ (2011)
  • Author(s): 島田英昭
  • Organizer: 第73回日本臨床外科学会総会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2011-11-17
• [Presentation] Clinical utility of serum p53 antibody for patients with esophageal carcinoma (2011)
  • Author(s): Shimada H
  • Organizer: 21st World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists
  • Place of Presentation: Keio Plaza Hotel, Tokyo
  • Year and Date: 2011-11-12
• [Presentation] Clinical utility of serum p53 antibody for patients with esophageal carcinoma (2011)
  • Author(s): Shimada H
  • Organizer: 21st World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists (IASGO2011)
  • Place of Presentation: Keio Plaza Hotel, Tokyo
  • Year and Date: 2011-11-12
• [Presentation] 食道癌診療におけるp53抗体マーカーの使い方入門編～PUBMED文献から (2011)
  • Author(s): 島田英昭
  • Organizer: 第65回日本食道学会学術集会
  • Place of Presentation: 仙台
  • Year and Date: 2011-09-26
• [Presentation] 食道癌診療におけるp53抗体マーカーの使い方入門編～PUBMED文献から (2011)
  • Author(s): 島田英昭
  • Organizer: 第65回日本食道学会学術集会
  • Place of Presentation: 仙台国際センター(仙台市)
  • Year and Date: 2011-09-26
• [Presentation] Serum SEREX antibodies as new biomarkers for gastric cancer (2011)
  • Author(s): Shimada H
  • Organizer: 9th International Gastric Cancer Congress
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2011-04-21
• [Presentation] Serum SEREX antibodies as new biomarkers for stage I/II gastric cancer (2010)
  • Author(s): Shimada H, Yamazaki K, Yajima S, Ooshima Y, Nanami T, Tamura A, Tsuchiya M, Maeda T, Suzuki T, Ootsuka Y, Kaneko H
  • Organizer: The 7th International Symposium on Can cer Research and Therapy
  • Place of Presentation: Tokyo
  • Year and Date: 2010-11-27
• [Presentation] Serum SEREX antibodies as new biomarkers for stage I/II gastric cancer. (2010)
  • Author(s): Shimada H, Yamazaki K, Yajima S, Ooshima Y, Nanami T, Tamura A, Tsuchiya M, Maeda T, Suzuki T, Ootsuka Y, Kaneko H
  • Organizer: The 7th International Symposium on Cancer Research and Therapy
  • Place of Presentation: 東京會舘(東京都)
  • Year and Date: 2010-11-27
• [Presentation] Serum IgG antibodies as new tumor markers for esophageal carcinoma (2010)
  • Author(s): Shimada H, Yajima S, Yamazaki K, Oshima Y, Kaneko H
  • Organizer: 12th World Congress of the International Society for Diseases of the Esophagus
  • Place of Presentation: Kagoshima
  • Year and Date: 2010-09-05
• [Presentation] Serum IgG antibodies as new tumor markers for esophageal carcinoma. (2010)
  • Author(s): Shimada H, Yajima S, Yamazaki K, Oshima Y, Kaneko H
  • Organizer: 12th World Congress of the International Society for Diseases of the Esophagus
  • Place of Presentation: 城山観光ホテル(鹿児島県)
  • Year and Date: 2010-09-05
• [Presentation] Clinical Significance of Serum p53 Antibodies in 1541 patients at Chiba Cancer Center from One-year Experience (2009)
  • Author(s): 島田英昭
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-02