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Association with permeation and metastasis of colon cancer and the hyaluronic acid ~For recurrent zero of colon cancer~

Research Project

Project/Area Number 21591718
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionHirosaki University

Principal Investigator

MURATA Akihiko  弘前大学, 医学部附属病院, 准教授 (10344607)

Co-Investigator(Renkei-kenkyūsha) YOSHIHARA Shuuichi  弘前大学, 大学院・医学研究科, 准教授 (00261454)
Project Period (FY) 2009 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsヒアルロン酸 / 大腸癌
Research Abstract

The accumulation of data was carried out by an effect of ME by confirmation and a visible bottom.Besides, it was recognized that we relatively reduced the cell adhesion ability and migration ability by reducing the hyaluronic acid production of the cancer cell.Also, the toxicity at the colon cancer cells level was confirmed indirectly.
Because that the effect on extracellular matrix of ME was not a little found was inferred, we performed the digitization with the microscope to visualize a thing and adhesive property to observe the cells activity including relations with the degree and level.

Report

(5 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (3 results)

All 2012

All Journal Article (1 results) Presentation (2 results)

  • [Journal Article] 局所進行直腸癌に対する放射線照射の効罰2012

    • Author(s)
      村田暁彦、小山基、坂本義之、諸橋一、神寛之、長瀬勇人、袴田健一
    • Journal Title

      癌の臨床

      Volume: 58 Pages: 367-373

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] 進行直腸癌に対する術前化学療法の成績2012

    • Author(s)
      村田暁彦、小山基、坂本義之、諸橋一、袴田健一
    • Organizer
      67回大腸肛門病学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Final Research Report
  • [Presentation] 進行直腸癌に対する術前化学療法の成績2012

    • Author(s)
      村田暁彦
    • Organizer
      第67回大腸肛門病学会
    • Place of Presentation
      福岡(国際会議場)
    • Related Report
      2012 Annual Research Report

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Published: 2009-04-01   Modified: 2019-07-29  

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