| Project/Area Number |
21591720
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Gunma University |
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Principal Investigator |
TSUTSUMI Soichi 群馬大学, 大学院・医学系研究科, 助教 (30323356)
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| Co-Investigator(Kenkyū-buntansha) |
ASAO Takayuki 群馬大学, 大学院・医学系研究科, 准教授 (40212469)
FUJII Takaaki 群馬大学, 医学部, 助教 (40507331)
KUWANO Hiroyuki 群馬大学, 大学院・医学系研究科, 教授 (90186560)
KOSAKA Takayuki 群馬大学, 医学部, 助教 (00507329)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2010: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2009: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
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| Keywords | 上皮間葉移行 / 抗癌剤耐性 / 骨髄幹細胞 / Epithelial-Mesenchymal Transition / 転移 |
|---|
| Research Abstract |
The epithelial to mesenchymal transition(EMT)is a molecular process through which an epithelial cell undergoes differentiation into a mesenchymal phenotype. The relationship between EMT and resistance to an anti-cancer drug in colorectal cancer remains unknown. In this study, we investigated the acquisition of EMT by 5-FU in colorectal cell lines. 5-FU resistant cell lines did not change into a mesenchymal phenotype. This study suggests that EMT phenotype may not play a significant role in anti-cancer agent resistance in colorectal cancer
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